(9 nodes) Retromer complex network (Oryzias latipes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	vps26b	VPS26, retromer complex component B. (333 aa)
	Snx1	Sorting nexin 1b. (305 aa)
	snx12	Sorting nexin 12. (162 aa)
	LOC101163736	Sorting nexin 1a. (668 aa)
	vps26a	VPS26, retromer complex component A. (328 aa)
	snx3	Sorting nexin 3. (162 aa)
	vps29	Vacuolar protein sorting-associated protein 29; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. (182 aa)
	tbc1d5	TBC1 domain family, member 5. (863 aa)
	snx2	Sorting nexin 2. (513 aa)

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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structured XML interaction data, according to the 'PSI-MI' data standard

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC101163736	snx12	ENSORLP00000002453	ENSORLP00000002261	Sorting nexin 1a.	Sorting nexin 12.	0.588
LOC101163736	snx2	ENSORLP00000002453	ENSORLP00000043960	Sorting nexin 1a.	Sorting nexin 2.	0.500
LOC101163736	snx3	ENSORLP00000002453	ENSORLP00000016846	Sorting nexin 1a.	Sorting nexin 3.	0.588
LOC101163736	vps26a	ENSORLP00000002453	ENSORLP00000012805	Sorting nexin 1a.	VPS26, retromer complex component A.	0.860
LOC101163736	vps26b	ENSORLP00000002453	ENSORLP00000006560	Sorting nexin 1a.	VPS26, retromer complex component B.	0.853
LOC101163736	vps29	ENSORLP00000002453	ENSORLP00000022447	Sorting nexin 1a.	Vacuolar protein sorting-associated protein 29; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway.	0.931
Snx1	snx2	ENSORLP00000001946	ENSORLP00000043960	Sorting nexin 1b.	Sorting nexin 2.	0.949
Snx1	vps26a	ENSORLP00000001946	ENSORLP00000012805	Sorting nexin 1b.	VPS26, retromer complex component A.	0.790
Snx1	vps26b	ENSORLP00000001946	ENSORLP00000006560	Sorting nexin 1b.	VPS26, retromer complex component B.	0.780
Snx1	vps29	ENSORLP00000001946	ENSORLP00000022447	Sorting nexin 1b.	Vacuolar protein sorting-associated protein 29; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway.	0.955
snx12	LOC101163736	ENSORLP00000002261	ENSORLP00000002453	Sorting nexin 12.	Sorting nexin 1a.	0.588
snx12	snx2	ENSORLP00000002261	ENSORLP00000043960	Sorting nexin 12.	Sorting nexin 2.	0.588
snx12	snx3	ENSORLP00000002261	ENSORLP00000016846	Sorting nexin 12.	Sorting nexin 3.	0.901
snx12	tbc1d5	ENSORLP00000002261	ENSORLP00000038751	Sorting nexin 12.	TBC1 domain family, member 5.	0.435
snx12	vps26a	ENSORLP00000002261	ENSORLP00000012805	Sorting nexin 12.	VPS26, retromer complex component A.	0.961
snx12	vps26b	ENSORLP00000002261	ENSORLP00000006560	Sorting nexin 12.	VPS26, retromer complex component B.	0.965
snx12	vps29	ENSORLP00000002261	ENSORLP00000022447	Sorting nexin 12.	Vacuolar protein sorting-associated protein 29; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway.	0.933
snx2	LOC101163736	ENSORLP00000043960	ENSORLP00000002453	Sorting nexin 2.	Sorting nexin 1a.	0.500
snx2	Snx1	ENSORLP00000043960	ENSORLP00000001946	Sorting nexin 2.	Sorting nexin 1b.	0.949
snx2	snx12	ENSORLP00000043960	ENSORLP00000002261	Sorting nexin 2.	Sorting nexin 12.	0.588