(59 nodes) WW domain network (Oryzias latipes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC101168748	Uncharacterized protein. (474 aa)
	cmtr1	Cap methyltransferase 1. (821 aa)
	H2MH85_ORYLA	Uncharacterized protein. (955 aa)
	LOC101171412	Uncharacterized protein. (1145 aa)
	pqbp1	Polyglutamine binding protein 1. (227 aa)
	LOC101160323	E3 ubiquitin-protein ligase. (770 aa)
	H2MJZ4_ORYLA	DGCR8 microprocessor complex subunit. (769 aa)
	LOC101159710	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2a. (1510 aa)
	magi2	Membrane associated guanylate kinase, WW and PDZ domain containing 2a. (1331 aa)
	fnbp4	Formin binding protein 4. (843 aa)
	mlh3	MutL homolog 3 (E. coli). (1125 aa)
	prpf40a	PRP40 pre-mRNA processing factor 40 homolog A. (874 aa)
	LOC101169248	Toll-like receptor 7. (1252 aa)
	wwox	WW domain containing oxidoreductase. (429 aa)
	LOC101161206	Uncharacterized protein. (1504 aa)
	wwp2	E3 ubiquitin-protein ligase. (885 aa)
	apbb1	Amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65). (687 aa)
	LOC105354474	MAGI family member, X-linked a. (1364 aa)
	wwc3	WWC family member 3. (1150 aa)
	TCERG1	Transcription elongation regulator 1. (1059 aa)
	iqgap1	IQ motif containing GTPase activating protein 1. (1661 aa)
	magi1	Membrane associated guanylate kinase, WW and PDZ domain containing 1b. (1724 aa)
	SMURF2	E3 ubiquitin-protein ligase. (795 aa)
	LOC101173221	Membrane associated guanylate kinase, WW and PDZ domain containing 2b. (1528 aa)
	plekha7	Pleckstrin homology domain containing, family A member 7a. (1389 aa)
	LOC101174746	E3 ubiquitin-protein ligase. (877 aa)
	LOC101156731	Zgc:92107. (1136 aa)
	bag3	BCL2 associated athanogene 3. (465 aa)
	ARHGAP9	Rho GTPase activating protein 9. (888 aa)
	setd2	SET domain containing 2, histone lysine methyltransferase. (2587 aa)
	cep164	WW domain-containing protein. (1526 aa)
	LOC101168460	Membrane associated guanylate kinase, WW and PDZ domain containing 1a. (1585 aa)
	LOC101159504	Uncharacterized protein. (1413 aa)
	LOC101167949	E3 ubiquitin-protein ligase. (879 aa)
	smurf1	E3 ubiquitin-protein ligase. (728 aa)
	hecw1	Si:ch211-188f17.1. (1639 aa)
	LOC101174805	Amyloid beta (A4) precursor protein-binding, family B, member 2b. (905 aa)
	arhgap39	Rho GTPase activating protein 39. (1000 aa)
	Nedd4	Uncharacterized protein. (403 aa)
	LOC101168066	Uncharacterized protein. (377 aa)
	yap1	Transcriptional coactivator YAP1; Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (By similarity). Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation. (440 aa)
	wbp4	Uncharacterized protein. (421 aa)
	ARHGAP12	Rho GTPase activating protein 12. (876 aa)
	LOC101169236	WW domain-containing protein. (544 aa)
	drp2	Dystrophin related protein 2. (878 aa)
	LOC101173072	Uncharacterized protein. (928 aa)
	nedd4l	NEDD4 like E3 ubiquitin protein ligase. (1207 aa)
	PLEKHA5	Pleckstrin homology domain containing A5. (1306 aa)
	wac	WW domain containing adaptor with coiled-coil a. (544 aa)
	wwp1	WW domain containing E3 ubiquitin protein ligase 1. (960 aa)
	LOC101158884	Uncharacterized protein. (861 aa)
	LOC101165134	Pleckstrin homology domain containing, family A member 7b. (1359 aa)
	LOC101160155	Membrane associated guanylate kinase, WW and PDZ domain containing 3b. (1467 aa)
	sav1	Salvador family WW domain containing protein 1. (391 aa)
	pcif1	PDX1 C-terminal inhibiting factor 1. (756 aa)
	pin1	Peptidyl-prolyl cis-trans isomerase. (156 aa)
	iqgap2	IQ motif containing GTPase activating protein 2. (1662 aa)
	LOC101169742	Rho GTPase activating protein 27. (970 aa)
	apbb3	Amyloid beta (A4) precursor protein-binding, family B, member 3. (512 aa)

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARHGAP12	iqgap1	ENSORLP00000005405	ENSORLP00000031127	Rho GTPase activating protein 12.	IQ motif containing GTPase activating protein 1.	0.447
ARHGAP12	iqgap2	ENSORLP00000005405	ENSORLP00000012236	Rho GTPase activating protein 12.	IQ motif containing GTPase activating protein 2.	0.447
ARHGAP12	yap1	ENSORLP00000005405	ENSORLP00000003377	Rho GTPase activating protein 12.	Transcriptional coactivator YAP1; Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (By similarity). Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation.	0.504
ARHGAP9	iqgap1	ENSORLP00000037272	ENSORLP00000031127	Rho GTPase activating protein 9.	IQ motif containing GTPase activating protein 1.	0.447
ARHGAP9	iqgap2	ENSORLP00000037272	ENSORLP00000012236	Rho GTPase activating protein 9.	IQ motif containing GTPase activating protein 2.	0.447
LOC101158884	iqgap1	ENSORLP00000002732	ENSORLP00000031127	Uncharacterized protein.	IQ motif containing GTPase activating protein 1.	0.447
LOC101158884	iqgap2	ENSORLP00000002732	ENSORLP00000012236	Uncharacterized protein.	IQ motif containing GTPase activating protein 2.	0.447
LOC101159710	sav1	ENSORLP00000019301	ENSORLP00000011283	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2a.	Salvador family WW domain containing protein 1.	0.475
LOC101160323	SMURF2	ENSORLP00000018986	ENSORLP00000035266	E3 ubiquitin-protein ligase.	E3 ubiquitin-protein ligase.	0.900
LOC101160323	sav1	ENSORLP00000018986	ENSORLP00000011283	E3 ubiquitin-protein ligase.	Salvador family WW domain containing protein 1.	0.666
LOC101161206	sav1	ENSORLP00000027083	ENSORLP00000011283	Uncharacterized protein.	Salvador family WW domain containing protein 1.	0.475
LOC101165134	sav1	ENSORLP00000008406	ENSORLP00000011283	Pleckstrin homology domain containing, family A member 7b.	Salvador family WW domain containing protein 1.	0.475
LOC101167949	LOC101174746	ENSORLP00000042687	ENSORLP00000036289	E3 ubiquitin-protein ligase.	E3 ubiquitin-protein ligase.	0.901
LOC101167949	sav1	ENSORLP00000042687	ENSORLP00000011283	E3 ubiquitin-protein ligase.	Salvador family WW domain containing protein 1.	0.475
LOC101167949	wwp1	ENSORLP00000042687	ENSORLP00000006490	E3 ubiquitin-protein ligase.	WW domain containing E3 ubiquitin protein ligase 1.	0.625
LOC101167949	wwp2	ENSORLP00000042687	ENSORLP00000027651	E3 ubiquitin-protein ligase.	E3 ubiquitin-protein ligase.	0.626
LOC101168066	sav1	ENSORLP00000007010	ENSORLP00000011283	Uncharacterized protein.	Salvador family WW domain containing protein 1.	0.475
LOC101168460	magi1	ENSORLP00000039075	ENSORLP00000032506	Membrane associated guanylate kinase, WW and PDZ domain containing 1a.	Membrane associated guanylate kinase, WW and PDZ domain containing 1b.	0.902
LOC101168748	iqgap1	ENSORLP00000016426	ENSORLP00000031127	Uncharacterized protein.	IQ motif containing GTPase activating protein 1.	0.546
LOC101168748	iqgap2	ENSORLP00000016426	ENSORLP00000012236	Uncharacterized protein.	IQ motif containing GTPase activating protein 2.	0.546