(53 nodes) PTB/PI domain network (Oryzias latipes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC101169696	PID domain-containing protein. (190 aa)
	H2LAE2_ORYLA	Tensin 1. (981 aa)
	appl2	Adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2. (666 aa)
	dab2	DAB adaptor protein 2. (761 aa)
	LOC101173072	Uncharacterized protein. (928 aa)
	tbc1d1	TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1. (1389 aa)
	SHC3	SHC adaptor protein 3. (665 aa)
	LOC101168113	Ankyrin repeat and sterile alpha motif domain containing 1Ab. (540 aa)
	fam43a	Family with sequence similarity 43 member A. (355 aa)
	H2LUK4_ORYLA	PID domain-containing protein. (102 aa)
	apbb3	Amyloid beta (A4) precursor protein-binding, family B, member 3. (512 aa)
	LOC101162033	Amyloid beta precursor protein binding family A member 3. (704 aa)
	LOC101156908	NUMB like endocytic adaptor protein. (550 aa)
	shc1	SHC (Src homology 2 domain containing) transforming protein 1. (449 aa)
	LOC101156607	Nitric oxide synthase 1 (neuronal) adaptor protein b. (500 aa)
	tbc1d4	TBC1 domain family, member 4. (1283 aa)
	TNS3	Tensin 3. (1228 aa)
	LOC101166648	Amyloid beta (A4) precursor protein-binding, family A, member 1b. (1077 aa)
	LOC101172559	Regulator of G protein signaling 12b. (1637 aa)
	itgb1bp1	Integrin beta 1 binding protein 1. (198 aa)
	anks1b	Ankyrin repeat and sterile alpha motif domain containing 1B. (1367 aa)
	fam43b	Family with sequence similarity 43 member B. (305 aa)
	ccm2	CCM2 scaffold protein. (461 aa)
	LOC101172728	Tensin 2b. (1541 aa)
	sh2d5	SH2 domain containing 5. (398 aa)
	TNS3-2	Tensin 3. (1362 aa)
	appl1	Adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1. (663 aa)
	ldlrap1	Low density lipoprotein receptor adaptor protein 1b. (320 aa)
	SHC4	SHC adaptor protein 4. (534 aa)
	apbb1	Amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65). (687 aa)
	LOC101167490	Si:dkey-19b23.8. (225 aa)
	MAPK8IP1	Mitogen-activated protein kinase 8 interacting protein 1. (876 aa)
	LOC101172441	DAB adaptor protein 1b. (566 aa)
	dab1	DAB adaptor protein 1a. (572 aa)
	rabgap1	RAB GTPase activating protein 1. (1091 aa)
	apba2	Amyloid beta (A4) precursor protein-binding, family A, member 2b. (919 aa)
	mapk8ip2	Mitogen-activated protein kinase 8 interacting protein 2. (1261 aa)
	EPS8L2	EPS8 like 2. (690 aa)
	gulp1	GULP PTB domain containing engulfment adaptor 1a. (395 aa)
	ANKS1A	Ankyrin repeat and sterile alpha motif domain containing 1A. (1157 aa)
	LOC101157471	Si:dkey-34e4.1. (648 aa)
	LOC101155555	Tensin 1b. (1736 aa)
	LOC101163480	PID domain-containing protein. (752 aa)
	LOC101163219	Si:dkey-71h2.2. (335 aa)
	RABGAP1L	RAB GTPase activating protein 1 like. (1032 aa)
	tns4	Tensin 4. (559 aa)
	pid1	Phosphotyrosine interaction domain containing 1. (225 aa)
	shc2	SHC (Src homology 2 domain containing) transforming protein 2. (711 aa)
	LOC101174278	Low density lipoprotein receptor adaptor protein 1a. (294 aa)
	LOC101160976	Amyloid beta (A4) precursor protein-binding, family A, member 2a. (820 aa)
	LOC101174805	Amyloid beta (A4) precursor protein-binding, family B, member 2b. (905 aa)
	LOC105354262	Uncharacterized protein. (351 aa)
	numb	NUMB endocytic adaptor protein. (671 aa)

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC101163219	appl1	ENSORLP00000039071	ENSORLP00000021749	Si:dkey-71h2.2.	Adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1.	0.661
LOC101163219	appl2	ENSORLP00000039071	ENSORLP00000003611	Si:dkey-71h2.2.	Adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2.	0.661
LOC101163219	dab2	ENSORLP00000039071	ENSORLP00000003668	Si:dkey-71h2.2.	DAB adaptor protein 2.	0.818
LOC101167490	appl1	ENSORLP00000028043	ENSORLP00000021749	Si:dkey-19b23.8.	Adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1.	0.661
LOC101167490	appl2	ENSORLP00000028043	ENSORLP00000003611	Si:dkey-19b23.8.	Adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2.	0.661
LOC101167490	dab2	ENSORLP00000028043	ENSORLP00000003668	Si:dkey-19b23.8.	DAB adaptor protein 2.	0.818
LOC101169696	appl1	ENSORLP00000001889	ENSORLP00000021749	PID domain-containing protein.	Adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1.	0.661
LOC101169696	appl2	ENSORLP00000001889	ENSORLP00000003611	PID domain-containing protein.	Adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2.	0.661
LOC101174278	appl1	ENSORLP00000040216	ENSORLP00000021749	Low density lipoprotein receptor adaptor protein 1a.	Adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1.	0.661
LOC101174278	appl2	ENSORLP00000040216	ENSORLP00000003611	Low density lipoprotein receptor adaptor protein 1a.	Adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2.	0.661
LOC101174278	dab2	ENSORLP00000040216	ENSORLP00000003668	Low density lipoprotein receptor adaptor protein 1a.	DAB adaptor protein 2.	0.880
LOC105354262	MAPK8IP1	ENSORLP00000043563	ENSORLP00000029434	Uncharacterized protein.	Mitogen-activated protein kinase 8 interacting protein 1.	0.902
LOC105354262	mapk8ip2	ENSORLP00000043563	ENSORLP00000035388	Uncharacterized protein.	Mitogen-activated protein kinase 8 interacting protein 2.	0.900
MAPK8IP1	LOC105354262	ENSORLP00000029434	ENSORLP00000043563	Mitogen-activated protein kinase 8 interacting protein 1.	Uncharacterized protein.	0.902
MAPK8IP1	mapk8ip2	ENSORLP00000029434	ENSORLP00000035388	Mitogen-activated protein kinase 8 interacting protein 1.	Mitogen-activated protein kinase 8 interacting protein 2.	0.904
appl1	LOC101163219	ENSORLP00000021749	ENSORLP00000039071	Adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1.	Si:dkey-71h2.2.	0.661
appl1	LOC101167490	ENSORLP00000021749	ENSORLP00000028043	Adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1.	Si:dkey-19b23.8.	0.661
appl1	LOC101169696	ENSORLP00000021749	ENSORLP00000001889	Adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1.	PID domain-containing protein.	0.661
appl1	LOC101174278	ENSORLP00000021749	ENSORLP00000040216	Adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1.	Low density lipoprotein receptor adaptor protein 1a.	0.661
appl1	appl2	ENSORLP00000021749	ENSORLP00000003611	Adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1.	Adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2.	0.992