(27 nodes) PLAT/LH2 domain superfamily network (Oryzias latipes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC101160547	PLAT domain-containing protein. (535 aa)
	LOC110014609	Uncharacterized protein. (662 aa)
	LOC101172731	Uncharacterized protein. (1298 aa)
	LOC101159319	Uncharacterized protein. (569 aa)
	LOC101168429	Uncharacterized protein. (629 aa)
	pkd1	Uncharacterized protein. (4114 aa)
	H2MRY0_ORYLA	Uncharacterized protein. (648 aa)
	LOC101172589	Uncharacterized protein. (634 aa)
	lpl	Lipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. (516 aa)
	LOC101162054	Uncharacterized protein. (633 aa)
	LOC101165367	Si:dkey-17e16.9. (706 aa)
	LOC101163757	Zgc:152891. (671 aa)
	LOC101174953	Arachidonate 12-lipoxygenase. (739 aa)
	lipc	Lipase, hepatic a. (496 aa)
	pkd1l2	Polycystic kidney disease 1 like 2a. (1638 aa)
	alox5	Arachidonate 5-lipoxygenase a. (673 aa)
	LOC101165945	Uncharacterized protein. (670 aa)
	loxhd1	Lipoxygenase homology domains 1a. (1911 aa)
	LOC101161894	Lipoxygenase homology domains 1b. (1853 aa)
	dennd5a	DENN/MADD domain containing 5A. (1301 aa)
	LOC101165239	Uncharacterized protein. (657 aa)
	LOC101162978	Uncharacterized protein. (633 aa)
	ENSORLP00000040630	PLAT domain-containing protein. (139 aa)
	pkd1l1	Polycystic kidney disease 1 like 1; Component of a ciliary calcium channel that controls calcium concentration within cilia without affecting cytoplasmic calcium concentration. Forms a heterodimer with pkd2l1 in cilia and forms a calcium-permeant ciliary channel that regulates sonic hedgehog/SHH signaling and gli2 transcription. Does not constitute the pore-forming subunit (By similarity). Also involved in left/right axis specification downstream of nodal flow: forms a complex with pkd2 in cilia to facilitate flow detection in left/right patterning. (2742 aa)
	LOC101174158	Uncharacterized protein. (640 aa)
	ENSORLP00000045920	Uncharacterized protein. (647 aa)
	lipg	Lipase, endothelial. (507 aa)

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC101160547	lipc	ENSORLP00000036096	ENSORLP00000010348	PLAT domain-containing protein.	Lipase, hepatic a.	0.660
LOC101160547	lipg	ENSORLP00000036096	ENSORLP00000002320	PLAT domain-containing protein.	Lipase, endothelial.	0.661
LOC101160547	lpl	ENSORLP00000036096	ENSORLP00000021263	PLAT domain-containing protein.	Lipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans.	0.903
LOC101162978	LOC101163757	ENSORLP00000034334	ENSORLP00000017118	Uncharacterized protein.	Zgc:152891.	0.765
LOC101162978	LOC101165239	ENSORLP00000034334	ENSORLP00000034145	Uncharacterized protein.	Uncharacterized protein.	0.753
LOC101162978	LOC101165945	ENSORLP00000034334	ENSORLP00000008447	Uncharacterized protein.	Uncharacterized protein.	0.664
LOC101162978	LOC101174158	ENSORLP00000034334	ENSORLP00000043152	Uncharacterized protein.	Uncharacterized protein.	0.654
LOC101162978	LOC101174953	ENSORLP00000034334	ENSORLP00000012944	Uncharacterized protein.	Arachidonate 12-lipoxygenase.	0.932
LOC101162978	alox5	ENSORLP00000034334	ENSORLP00000009355	Uncharacterized protein.	Arachidonate 5-lipoxygenase a.	0.931
LOC101163757	LOC101162978	ENSORLP00000017118	ENSORLP00000034334	Zgc:152891.	Uncharacterized protein.	0.765
LOC101163757	LOC101165239	ENSORLP00000017118	ENSORLP00000034145	Zgc:152891.	Uncharacterized protein.	0.677
LOC101163757	LOC101165945	ENSORLP00000017118	ENSORLP00000008447	Zgc:152891.	Uncharacterized protein.	0.758
LOC101163757	LOC101174158	ENSORLP00000017118	ENSORLP00000043152	Zgc:152891.	Uncharacterized protein.	0.766
LOC101163757	LOC101174953	ENSORLP00000017118	ENSORLP00000012944	Zgc:152891.	Arachidonate 12-lipoxygenase.	0.906
LOC101163757	alox5	ENSORLP00000017118	ENSORLP00000009355	Zgc:152891.	Arachidonate 5-lipoxygenase a.	0.907
LOC101165239	LOC101162978	ENSORLP00000034145	ENSORLP00000034334	Uncharacterized protein.	Uncharacterized protein.	0.753
LOC101165239	LOC101163757	ENSORLP00000034145	ENSORLP00000017118	Uncharacterized protein.	Zgc:152891.	0.677
LOC101165239	LOC101165945	ENSORLP00000034145	ENSORLP00000008447	Uncharacterized protein.	Uncharacterized protein.	0.751
LOC101165239	LOC101174158	ENSORLP00000034145	ENSORLP00000043152	Uncharacterized protein.	Uncharacterized protein.	0.753
LOC101165239	LOC101174953	ENSORLP00000034145	ENSORLP00000012944	Uncharacterized protein.	Arachidonate 12-lipoxygenase.	0.905