(25 nodes) Histidine kinase/HSP90-like ATPase superfamily network (Oryzias latipes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	top2a	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1571 aa)
	hsp90b1	Heat shock protein 90, beta (grp94), member 1. (796 aa)
	LOC101175172	Zgc:152774. (879 aa)
	pms2	PMS1 homolog 2, mismatch repair system component. (828 aa)
	ENSORLP00000045210	HEPN domain-containing protein. (4255 aa)
	LOC101169573	HEPN domain-containing protein. (4262 aa)
	pdk1	Protein-serine/threonine kinase. (413 aa)
	top2b	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1599 aa)
	LOC101171115	DUF3883 domain-containing protein. (2341 aa)
	mlh1	MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli). (720 aa)
	pdk4	Protein-serine/threonine kinase. (410 aa)
	hsp90ab1	Heat shock protein 90, alpha (cytosolic), class B member 1. (724 aa)
	ENSORLP00000033150	Uncharacterized protein. (162 aa)
	sacs	Sacsin molecular chaperone. (4579 aa)
	LOC101162250	Wu:fj29h11. (2771 aa)
	H2MUF4_ORYLA	Uncharacterized protein. (162 aa)
	mlh3	MutL homolog 3 (E. coli). (1125 aa)
	pms1	PMS1 homolog 1, mismatch repair system component. (991 aa)
	bckdk	Protein-serine/threonine kinase. (494 aa)
	LOC101175202	Protein-serine/threonine kinase. (408 aa)
	LOC101169506	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2. (730 aa)
	H2M6M6_ORYLA	Structural maintenance of chromosomes flexible hinge domain containing 1. (1384 aa)
	trap1	TNF receptor-associated protein 1. (715 aa)
	morc2	MORC family CW-type zinc finger 2. (847 aa)
	pdk3	Protein-serine/threonine kinase. (406 aa)

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC101169506	LOC101175202	ENSORLP00000014900	ENSORLP00000015232	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2.	Protein-serine/threonine kinase.	0.400
LOC101169506	bckdk	ENSORLP00000014900	ENSORLP00000018272	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2.	Protein-serine/threonine kinase.	0.405
LOC101169506	hsp90ab1	ENSORLP00000014900	ENSORLP00000033219	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2.	Heat shock protein 90, alpha (cytosolic), class B member 1.	0.946
LOC101169506	hsp90b1	ENSORLP00000014900	ENSORLP00000005467	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2.	Heat shock protein 90, beta (grp94), member 1.	0.929
LOC101169506	pdk1	ENSORLP00000014900	ENSORLP00000038258	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2.	Protein-serine/threonine kinase.	0.400
LOC101169506	pdk3	ENSORLP00000014900	ENSORLP00000009459	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2.	Protein-serine/threonine kinase.	0.400
LOC101169506	pdk4	ENSORLP00000014900	ENSORLP00000033820	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2.	Protein-serine/threonine kinase.	0.400
LOC101175202	LOC101169506	ENSORLP00000015232	ENSORLP00000014900	Protein-serine/threonine kinase.	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2.	0.400
LOC101175202	hsp90ab1	ENSORLP00000015232	ENSORLP00000033219	Protein-serine/threonine kinase.	Heat shock protein 90, alpha (cytosolic), class B member 1.	0.400
LOC101175202	trap1	ENSORLP00000015232	ENSORLP00000010499	Protein-serine/threonine kinase.	TNF receptor-associated protein 1.	0.400
bckdk	LOC101169506	ENSORLP00000018272	ENSORLP00000014900	Protein-serine/threonine kinase.	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2.	0.405
bckdk	hsp90ab1	ENSORLP00000018272	ENSORLP00000033219	Protein-serine/threonine kinase.	Heat shock protein 90, alpha (cytosolic), class B member 1.	0.405
bckdk	trap1	ENSORLP00000018272	ENSORLP00000010499	Protein-serine/threonine kinase.	TNF receptor-associated protein 1.	0.402
hsp90ab1	LOC101169506	ENSORLP00000033219	ENSORLP00000014900	Heat shock protein 90, alpha (cytosolic), class B member 1.	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2.	0.946
hsp90ab1	LOC101175202	ENSORLP00000033219	ENSORLP00000015232	Heat shock protein 90, alpha (cytosolic), class B member 1.	Protein-serine/threonine kinase.	0.400
hsp90ab1	bckdk	ENSORLP00000033219	ENSORLP00000018272	Heat shock protein 90, alpha (cytosolic), class B member 1.	Protein-serine/threonine kinase.	0.405
hsp90ab1	hsp90b1	ENSORLP00000033219	ENSORLP00000005467	Heat shock protein 90, alpha (cytosolic), class B member 1.	Heat shock protein 90, beta (grp94), member 1.	0.929
hsp90ab1	pdk1	ENSORLP00000033219	ENSORLP00000038258	Heat shock protein 90, alpha (cytosolic), class B member 1.	Protein-serine/threonine kinase.	0.400
hsp90ab1	pdk3	ENSORLP00000033219	ENSORLP00000009459	Heat shock protein 90, alpha (cytosolic), class B member 1.	Protein-serine/threonine kinase.	0.400
hsp90ab1	pdk4	ENSORLP00000033219	ENSORLP00000033820	Heat shock protein 90, alpha (cytosolic), class B member 1.	Protein-serine/threonine kinase.	0.400