35 items (Oryzias latipes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PIK3R5	Phosphoinositide-3-kinase regulatory subunit 5. (861 aa)
	mfsd6	Major facilitator superfamily domain containing 6a. (731 aa)
	LOC101172160	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (594 aa)
	LOC101159013	Si:rp71-17i16.5; Belongs to the PI3/PI4-kinase family. (1106 aa)
	pik3r1	Phosphoinositide-3-kinase, regulatory subunit 1 (alpha). (728 aa)
	PIK3R6	Phosphoinositide-3-kinase regulatory subunit 6. (774 aa)
	pik3r5	Phosphoinositide-3-kinase, regulatory subunit 5. (883 aa)
	prdm2	PR domain containing 2, with ZNF domain b. (1677 aa)
	LOC101156736	Uncharacterized protein. (1289 aa)
	H2LP85_ORYLA	Ras homolog gene family, member Gd. (120 aa)
	LOC101164658	Uncharacterized protein. (242 aa)
	pdpk1	3-phosphoinositide dependent protein kinase 1b. (568 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	LOC101168152	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	pik3cg	Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1121 aa)
	LOC101155144	Uncharacterized protein. (466 aa)
	SPNS2	Sphingolipid transporter 2. (503 aa)
	LOC101168888	Spinster homolog 3 (Drosophila). (519 aa)
	CDC42	Cell division cycle 42. (191 aa)
	LOC101162944	Ras homolog family member Gb. (191 aa)
	H2MSU3_ORYLA	Uncharacterized protein. (420 aa)
	LOC101163728	Uncharacterized protein. (409 aa)
	clnk	SH2 domain-containing protein. (350 aa)
	LOC101174454	Uncharacterized protein. (191 aa)
	VAV1	Vav guanine nucleotide exchange factor 1. (902 aa)
	vav2	Vav 2 guanine nucleotide exchange factor. (922 aa)
	mfsd6l	Major facilitator superfamily domain containing 6-like. (587 aa)
	pik3r3	Phosphoinositide-3-kinase, regulatory subunit 3b (gamma). (719 aa)
	pik3cb	Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1078 aa)
	LOC101164400	Uncharacterized protein. (191 aa)
	syk	Tyrosine-protein kinase. (624 aa)
	VAV3	Vav guanine nucleotide exchange factor 3. (864 aa)
	ptpn11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (596 aa)
	LOC101160624	Vav 3 guanine nucleotide exchange factor b. (904 aa)
	spns1	Spinster homolog 1 (Drosophila). (504 aa)

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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structured XML interaction data, according to the 'PSI-MI' data standard

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

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... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDC42	H2LP85_ORYLA	ENSORLP00000015084	ENSORLP00000007865	Cell division cycle 42.	Ras homolog gene family, member Gd.	0.508
CDC42	H2MSU3_ORYLA	ENSORLP00000015084	ENSORLP00000021836	Cell division cycle 42.	Uncharacterized protein.	0.494
CDC42	LOC101160624	ENSORLP00000015084	ENSORLP00000043794	Cell division cycle 42.	Vav 3 guanine nucleotide exchange factor b.	0.640
CDC42	LOC101162944	ENSORLP00000015084	ENSORLP00000017316	Cell division cycle 42.	Ras homolog family member Gb.	0.505
CDC42	LOC101168152	ENSORLP00000015084	ENSORLP00000011212	Cell division cycle 42.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.667
CDC42	PIK3CA	ENSORLP00000015084	ENSORLP00000011211	Cell division cycle 42.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.667
CDC42	VAV1	ENSORLP00000015084	ENSORLP00000031105	Cell division cycle 42.	Vav guanine nucleotide exchange factor 1.	0.640
CDC42	VAV3	ENSORLP00000015084	ENSORLP00000038251	Cell division cycle 42.	Vav guanine nucleotide exchange factor 3.	0.640
CDC42	pdpk1	ENSORLP00000015084	ENSORLP00000009715	Cell division cycle 42.	3-phosphoinositide dependent protein kinase 1b.	0.470
CDC42	pik3cb	ENSORLP00000015084	ENSORLP00000034377	Cell division cycle 42.	Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta; Belongs to the PI3/PI4-kinase family.	0.667
CDC42	pik3r1	ENSORLP00000015084	ENSORLP00000003326	Cell division cycle 42.	Phosphoinositide-3-kinase, regulatory subunit 1 (alpha).	0.494
CDC42	pik3r3	ENSORLP00000015084	ENSORLP00000034046	Cell division cycle 42.	Phosphoinositide-3-kinase, regulatory subunit 3b (gamma).	0.494
CDC42	vav2	ENSORLP00000015084	ENSORLP00000033098	Cell division cycle 42.	Vav 2 guanine nucleotide exchange factor.	0.640
H2LP85_ORYLA	CDC42	ENSORLP00000007865	ENSORLP00000015084	Ras homolog gene family, member Gd.	Cell division cycle 42.	0.508
H2LP85_ORYLA	H2MSU3_ORYLA	ENSORLP00000007865	ENSORLP00000021836	Ras homolog gene family, member Gd.	Uncharacterized protein.	0.448
H2LP85_ORYLA	LOC101160624	ENSORLP00000007865	ENSORLP00000043794	Ras homolog gene family, member Gd.	Vav 3 guanine nucleotide exchange factor b.	0.603
H2LP85_ORYLA	LOC101162944	ENSORLP00000007865	ENSORLP00000017316	Ras homolog gene family, member Gd.	Ras homolog family member Gb.	0.901
H2LP85_ORYLA	LOC101164400	ENSORLP00000007865	ENSORLP00000034529	Ras homolog gene family, member Gd.	Uncharacterized protein.	0.509
H2LP85_ORYLA	LOC101164658	ENSORLP00000007865	ENSORLP00000007959	Ras homolog gene family, member Gd.	Uncharacterized protein.	0.429
H2LP85_ORYLA	LOC101168152	ENSORLP00000007865	ENSORLP00000011212	Ras homolog gene family, member Gd.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.679