51 items (Oryzias latipes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC101163116	Neuregulin 3b. (763 aa)
	erbb3	Protein kinase domain-containing protein. (1411 aa)
	LOC101166137	EGF-like domain-containing protein. (154 aa)
	yap1	Transcriptional coactivator YAP1; Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (By similarity). Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation. (440 aa)
	NCSTN	Nicastrin. (677 aa)
	LOC101158081	Uncharacterized protein. (380 aa)
	LOC101163082	Signal transducer and activator of transcription. (786 aa)
	wwp1	WW domain containing E3 ubiquitin protein ligase 1. (960 aa)
	mxd4	MAX dimerization protein 4. (217 aa)
	psenen	Presenilin enhancer, gamma-secretase subunit. (101 aa)
	SRC	Tyrosine-protein kinase. (544 aa)
	LOC101172978	Erb-b2 receptor tyrosine kinase 3b. (1376 aa)
	ADAP1	ArfGAP with dual PH domains 1. (377 aa)
	LOC101171182	Crystallin, beta B1, like 3; Belongs to the beta/gamma-crystallin family. (209 aa)
	uba52	Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	LOC101168152	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	shc1	SHC (Src homology 2 domain containing) transforming protein 1. (449 aa)
	LOC101166303	ArfGAP with dual PH domains 2. (378 aa)
	hras	HRas proto-oncogene, GTPase a. (189 aa)
	fndc3b	Fibronectin type III domain containing 3Ba. (1209 aa)
	H2M970_ORYLA	Ubiquitin-like domain-containing protein. (129 aa)
	ubc	Ubiquitin B. (782 aa)
	grb2	Growth factor receptor-bound protein 2b. (218 aa)
	erbb4	Receptor protein-tyrosine kinase. (1375 aa)
	LOC101159650	APH1B gamma secretase subunit. (258 aa)
	psen2	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (421 aa)
	wwox	WW domain containing oxidoreductase. (429 aa)
	SHC4	SHC adaptor protein 4. (534 aa)
	LOC101159516	Neuregulin 2b. (712 aa)
	LOC101154954	Zgc:55558. (189 aa)
	kras	GTPase KRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (By similarity). Plays an important role in the regulation of cell proliferation. (189 aa)
	LOC101165379	Receptor protein-tyrosine kinase. (1494 aa)
	Nedd4	Uncharacterized protein. (403 aa)
	LOC105355769	EGF-like domain-containing protein. (520 aa)
	egf	Epidermal growth factor. (966 aa)
	LOC101160461	EGF-like domain-containing protein. (607 aa)
	CSDE1	Cold shock domain containing E1, RNA-binding. (875 aa)
	LOC101164480	Tyrosine-protein kinase. (551 aa)
	LOC101174746	E3 ubiquitin-protein ligase. (877 aa)
	LOC101155207	Betacellulin, epidermal growth factor family member. (183 aa)
	LOC101154844	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (410 aa)
	rps27a	Ribosomal protein S27a. (195 aa)
	LOC101164582	Neuregulin 2a. (711 aa)
	ENSORLP00000040294	Stathmin; Belongs to the stathmin family. (125 aa)
	fndc3a	Fibronectin type III domain containing 3A. (1244 aa)
	LOC101155162	Uncharacterized protein. (373 aa)
	ENSORLP00000041845	HECT domain-containing protein. (106 aa)
	LOC101168657	Signal transducer and activator of transcription. (785 aa)
	esr1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (634 aa)
	LOC101167949	E3 ubiquitin-protein ligase. (879 aa)

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CSDE1	H2M970_ORYLA	ENSORLP00000034821	ENSORLP00000015051	Cold shock domain containing E1, RNA-binding.	Ubiquitin-like domain-containing protein.	0.456
CSDE1	LOC101155207	ENSORLP00000034821	ENSORLP00000037400	Cold shock domain containing E1, RNA-binding.	Betacellulin, epidermal growth factor family member.	0.425
CSDE1	LOC101164480	ENSORLP00000034821	ENSORLP00000036233	Cold shock domain containing E1, RNA-binding.	Tyrosine-protein kinase.	0.417
CSDE1	LOC101165379	ENSORLP00000034821	ENSORLP00000031995	Cold shock domain containing E1, RNA-binding.	Receptor protein-tyrosine kinase.	0.516
CSDE1	LOC101166137	ENSORLP00000034821	ENSORLP00000002190	Cold shock domain containing E1, RNA-binding.	EGF-like domain-containing protein.	0.440
CSDE1	LOC101168152	ENSORLP00000034821	ENSORLP00000011212	Cold shock domain containing E1, RNA-binding.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.530
CSDE1	LOC101172978	ENSORLP00000034821	ENSORLP00000009628	Cold shock domain containing E1, RNA-binding.	Erb-b2 receptor tyrosine kinase 3b.	0.516
CSDE1	PIK3CA	ENSORLP00000034821	ENSORLP00000011211	Cold shock domain containing E1, RNA-binding.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.530
CSDE1	SHC4	ENSORLP00000034821	ENSORLP00000027207	Cold shock domain containing E1, RNA-binding.	SHC adaptor protein 4.	0.419
CSDE1	SRC	ENSORLP00000034821	ENSORLP00000008431	Cold shock domain containing E1, RNA-binding.	Tyrosine-protein kinase.	0.417
CSDE1	egf	ENSORLP00000034821	ENSORLP00000034297	Cold shock domain containing E1, RNA-binding.	Epidermal growth factor.	0.499
CSDE1	erbb3	ENSORLP00000034821	ENSORLP00000001883	Cold shock domain containing E1, RNA-binding.	Protein kinase domain-containing protein.	0.516
CSDE1	erbb4	ENSORLP00000034821	ENSORLP00000020056	Cold shock domain containing E1, RNA-binding.	Receptor protein-tyrosine kinase.	0.516
CSDE1	grb2	ENSORLP00000034821	ENSORLP00000019097	Cold shock domain containing E1, RNA-binding.	Growth factor receptor-bound protein 2b.	0.691
CSDE1	rps27a	ENSORLP00000034821	ENSORLP00000038189	Cold shock domain containing E1, RNA-binding.	Ribosomal protein S27a.	0.481
CSDE1	shc1	ENSORLP00000034821	ENSORLP00000012223	Cold shock domain containing E1, RNA-binding.	SHC (Src homology 2 domain containing) transforming protein 1.	0.419
CSDE1	uba52	ENSORLP00000034821	ENSORLP00000010731	Cold shock domain containing E1, RNA-binding.	Ubiquitin A-52 residue ribosomal protein fusion product 1.	0.456
CSDE1	ubc	ENSORLP00000034821	ENSORLP00000015065	Cold shock domain containing E1, RNA-binding.	Ubiquitin B.	0.539
ENSORLP00000041845	H2M970_ORYLA	ENSORLP00000041845	ENSORLP00000015051	HECT domain-containing protein.	Ubiquitin-like domain-containing protein.	0.666
ENSORLP00000041845	LOC101165379	ENSORLP00000041845	ENSORLP00000031995	HECT domain-containing protein.	Receptor protein-tyrosine kinase.	0.442