32 items (Oryzias latipes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC101158464	Rap guanine nucleotide exchange factor (GEF) 1b. (1184 aa)
	frs2	Fibroblast growth factor receptor substrate 2b. (526 aa)
	LOC101167252	V-ral simian leukemia viral oncogene homolog Aa (ras related). (206 aa)
	shc2	SHC (Src homology 2 domain containing) transforming protein 2. (711 aa)
	LOC101162905	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (369 aa)
	ntf3	Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (284 aa)
	LOC101162042	Mitogen-activated protein kinase. (361 aa)
	CSDE1	Cold shock domain containing E1, RNA-binding. (875 aa)
	LOC110016423	Uncharacterized protein. (313 aa)
	kras	GTPase KRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (By similarity). Plays an important role in the regulation of cell proliferation. (189 aa)
	LOC101157118	V-ral simian leukemia viral oncogene homolog Ba (ras related). (207 aa)
	LOC101154954	Zgc:55558. (189 aa)
	LOC101160731	Mitogen-activated protein kinase. (360 aa)
	ralgds	Ral guanine nucleotide dissociation stimulator. (774 aa)
	H2MX42_ORYLA	Zgc:171775. (273 aa)
	LOC101173112	Kinase D-interacting substrate 220b. (1713 aa)
	LOC101155812	ANK_REP_REGION domain-containing protein. (1684 aa)
	rapgef1	Uncharacterized protein. (881 aa)
	MAPKAPK2	MAPK activated protein kinase 2a; Belongs to the protein kinase superfamily. (389 aa)
	LOC101159256	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa)
	LOC101159747	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (389 aa)
	hras	HRas proto-oncogene, GTPase a. (189 aa)
	crkl	V-crk avian sarcoma virus CT10 oncogene homolog-like. (306 aa)
	crk	CRK proto-oncogene, adaptor protein. (315 aa)
	LOC101175696	Mitogen-activated protein kinase. (354 aa)
	LOC101157368	Nerve growth factor a (beta polypeptide); Belongs to the NGF-beta family. (291 aa)
	map2k1	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (394 aa)
	LOC101164147	Nerve growth factor b (beta polypeptide); Belongs to the NGF-beta family. (198 aa)
	SHC3	SHC adaptor protein 3. (665 aa)
	map2k2	Mitogen-activated protein kinase kinase 2a; Belongs to the protein kinase superfamily. (397 aa)
	nkpd1	NTPase, KAP family P-loop domain containing 1. (686 aa)
	LOC101156149	Uncharacterized protein. (201 aa)

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CSDE1	LOC101158464	ENSORLP00000034821	ENSORLP00000030168	Cold shock domain containing E1, RNA-binding.	Rap guanine nucleotide exchange factor (GEF) 1b.	0.414
CSDE1	LOC101159747	ENSORLP00000034821	ENSORLP00000015020	Cold shock domain containing E1, RNA-binding.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.459
CSDE1	LOC101162905	ENSORLP00000034821	ENSORLP00000039541	Cold shock domain containing E1, RNA-binding.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.459
CSDE1	SHC3	ENSORLP00000034821	ENSORLP00000007238	Cold shock domain containing E1, RNA-binding.	SHC adaptor protein 3.	0.419
CSDE1	frs2	ENSORLP00000034821	ENSORLP00000044911	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor receptor substrate 2b.	0.448
CSDE1	map2k1	ENSORLP00000034821	ENSORLP00000008701	Cold shock domain containing E1, RNA-binding.	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily.	0.600
CSDE1	map2k2	ENSORLP00000034821	ENSORLP00000006223	Cold shock domain containing E1, RNA-binding.	Mitogen-activated protein kinase kinase 2a; Belongs to the protein kinase superfamily.	0.600
CSDE1	ralgds	ENSORLP00000034821	ENSORLP00000025580	Cold shock domain containing E1, RNA-binding.	Ral guanine nucleotide dissociation stimulator.	0.733
CSDE1	rapgef1	ENSORLP00000034821	ENSORLP00000020777	Cold shock domain containing E1, RNA-binding.	Uncharacterized protein.	0.414
H2MX42_ORYLA	LOC101159256	ENSORLP00000023483	ENSORLP00000016665	Zgc:171775.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.788
H2MX42_ORYLA	MAPKAPK2	ENSORLP00000023483	ENSORLP00000019719	Zgc:171775.	MAPK activated protein kinase 2a; Belongs to the protein kinase superfamily.	0.796
H2MX42_ORYLA	map2k1	ENSORLP00000023483	ENSORLP00000008701	Zgc:171775.	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily.	0.694
H2MX42_ORYLA	map2k2	ENSORLP00000023483	ENSORLP00000006223	Zgc:171775.	Mitogen-activated protein kinase kinase 2a; Belongs to the protein kinase superfamily.	0.694
LOC101154954	LOC101158464	ENSORLP00000030026	ENSORLP00000030168	Zgc:55558.	Rap guanine nucleotide exchange factor (GEF) 1b.	0.414
LOC101154954	LOC101159747	ENSORLP00000030026	ENSORLP00000015020	Zgc:55558.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.459
LOC101154954	LOC101162905	ENSORLP00000030026	ENSORLP00000039541	Zgc:55558.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.459
LOC101154954	SHC3	ENSORLP00000030026	ENSORLP00000007238	Zgc:55558.	SHC adaptor protein 3.	0.419
LOC101154954	frs2	ENSORLP00000030026	ENSORLP00000044911	Zgc:55558.	Fibroblast growth factor receptor substrate 2b.	0.448
LOC101154954	hras	ENSORLP00000030026	ENSORLP00000014318	Zgc:55558.	HRas proto-oncogene, GTPase a.	0.911
LOC101154954	kras	ENSORLP00000030026	ENSORLP00000031976	Zgc:55558.	GTPase KRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (By similarity). Plays an important role in the regulation of cell proliferation.	0.901