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polr2i polr2i H2LC37_ORYLA H2LC37_ORYLA polr2g polr2g kl kl gtf2f2 gtf2f2 klb klb LOC101171145 LOC101171145 polr2d polr2d LOC101161650 LOC101161650 fgf16 fgf16 SRC SRC LOC101167061 LOC101167061 cbl cbl Fgfbp2 Fgfbp2 LOC101174914 LOC101174914 uba52 uba52 PIK3CA PIK3CA LOC101168152 LOC101168152 anos1b anos1b shc1 shc1 LOC101167065 LOC101167065 LOC101171210 LOC101171210 LOC101162992 LOC101162992 mknk2 mknk2 polr2j polr2j plcg1 plcg1 LOC101165069 LOC101165069 LOC101154954 LOC101154954 ENSORLP00000029856 ENSORLP00000029856 PTBP2 PTBP2 lctl lctl hnrnpm hnrnpm spred1 spred1 LOC101164354 LOC101164354 ppp2cb ppp2cb ENSORLP00000027361 ENSORLP00000027361 SHC4 SHC4 tial1 tial1 ptbp1b ptbp1b polr2l polr2l NCBP1 NCBP1 fgf20b fgf20b polr2b polr2b LCT LCT fgfr3 fgfr3 GALNT3 GALNT3 mknk1 mknk1 LOC101162725 LOC101162725 fgf23 fgf23 FGF6 FGF6 LOC101158614 LOC101158614 POLR2E POLR2E grb2 grb2 polr2c polr2c polr2f polr2f LOC101163758 LOC101163758 fgfr1 fgfr1 LOC100049521 LOC100049521 LOC105354870 LOC105354870 fgfr2 fgfr2 ubc ubc H2M970_ORYLA H2M970_ORYLA LOC101159747 LOC101159747 LOC101173047 LOC101173047 fndc3b fndc3b hras hras ncbp2 ncbp2 LOC101155126 LOC101155126 frs2 frs2 gtf2f1 gtf2f1 FGF6-2 FGF6-2 LOC101159420 LOC101159420 LOC101158476 LOC101158476 fgf20a fgf20a fgf8 fgf8 fgfbp3 fgfbp3 gab1 gab1 ptbp1 ptbp1 fgf10 fgf10 fndc3a fndc3a LOC101157091 LOC101157091 FGFRL1 FGFRL1 LOC101162905 LOC101162905 polr2h polr2h fgf18 fgf18 LOC105358735 LOC105358735 fgf5 fgf5 rps27a rps27a polr2a polr2a Lct Lct LOC101164480 LOC101164480 CSDE1 CSDE1 anos1 anos1 LOC101164556 LOC101164556 ptbp2 ptbp2 flrt3 flrt3 ENSORLP00000033909 ENSORLP00000033909 ENSORLP00000032568 ENSORLP00000032568 kras kras esrp1 esrp1 fgf19 fgf19 fgf4 fgf4 fgf3 fgf3 ppp2ca ppp2ca Fgf1 Fgf1 LOC101174825 LOC101174825 fgf7 fgf7 SPRED2 SPRED2 LOC101155125 LOC101155125
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
polr2iDNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (126 aa)
H2LC37_ORYLAUncharacterized protein. (66 aa)
polr2gPolymerase (RNA) II (DNA directed) polypeptide G-like. (175 aa)
klKlotho. (975 aa)
gtf2f2General transcription factor IIF subunit 2; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity. (267 aa)
klbKlotho beta. (1045 aa)
LOC101171145Sprouty RTK signaling antagonist 2. (342 aa)
polr2dPolymerase (RNA) II (DNA directed) polypeptide D. (144 aa)
LOC101161650Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (157 aa)
fgf16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (217 aa)
SRCTyrosine-protein kinase. (544 aa)
LOC101167061Protein phosphatase 2, regulatory subunit A, beta b. (589 aa)
cblCbl proto-oncogene, E3 ubiquitin protein ligase. (946 aa)
Fgfbp2Fibroblast growth factor binding protein 2b. (231 aa)
LOC101174914Uncharacterized protein. (329 aa)
uba52Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
LOC101168152Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
anos1bAnosmin-1.2. (704 aa)
shc1SHC (Src homology 2 domain containing) transforming protein 1. (449 aa)
LOC101167065Fibronectin leucine rich transmembrane protein 1. (685 aa)
LOC101171210Fibronectin leucine rich transmembrane protein 2. (653 aa)
LOC101162992Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (223 aa)
mknk2MAPK interacting serine/threonine kinase 2b; Belongs to the protein kinase superfamily. (475 aa)
polr2jPolymerase (RNA) II (DNA directed) polypeptide J. (141 aa)
plcg11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1311 aa)
LOC101165069Fibroblast growth factor receptor like 1a. (494 aa)
LOC101154954Zgc:55558. (189 aa)
ENSORLP00000029856Lactase. (1831 aa)
PTBP2Polypyrimidine tract binding protein 2a. (515 aa)
lctlLactase-like b; Belongs to the glycosyl hydrolase 1 family. (585 aa)
hnrnpmHeterogeneous nuclear ribonucleoprotein M. (668 aa)
spred1Sprouty related EVH1 domain containing 1. (542 aa)
LOC101164354TFIIF_beta domain-containing protein. (305 aa)
ppp2cbSerine/threonine-protein phosphatase. (309 aa)
ENSORLP00000027361Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (250 aa)
SHC4SHC adaptor protein 4. (534 aa)
tial1TIA1 cytotoxic granule-associated RNA binding protein-like 1. (397 aa)
ptbp1bUncharacterized protein. (562 aa)
polr2lPolymerase (RNA) II (DNA directed) polypeptide L. (68 aa)
NCBP1Nuclear cap binding protein subunit 1. (799 aa)
fgf20bFibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
polr2bDNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1174 aa)
LCTLactase. (1849 aa)
fgfr3Fibroblast growth factor receptor. (820 aa)
GALNT3Polypeptide N-acetylgalactosaminyltransferase. (624 aa)
mknk1MAPK interacting serine/threonine kinase 1; Belongs to the protein kinase superfamily. (457 aa)
LOC101162725Fibronectin leucine rich transmembrane protein 2. (658 aa)
fgf23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (263 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (198 aa)
LOC101158614TIA1 cytotoxic granule-associated RNA binding protein. (386 aa)
POLR2ERNA polymerase II subunit E. (210 aa)
grb2Growth factor receptor-bound protein 2b. (218 aa)
polr2cPolymerase (RNA) II (DNA directed) polypeptide C. (275 aa)
polr2fPolymerase (RNA) II (DNA directed) polypeptide F. (127 aa)
LOC101163758Uncharacterized protein. (852 aa)
fgfr1Fibroblast growth factor receptor. (833 aa)
LOC100049521Fibroblast growth factor receptor 4. (1075 aa)
LOC105354870Fibronectin leucine rich transmembrane protein 1b. (729 aa)
fgfr2Fibroblast growth factor receptor. (832 aa)
ubcUbiquitin B. (782 aa)
H2M970_ORYLAUbiquitin-like domain-containing protein. (129 aa)
LOC101159747Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (389 aa)
LOC101173047Epithelial splicing regulatory protein 2. (738 aa)
fndc3bFibronectin type III domain containing 3Ba. (1209 aa)
hrasHRas proto-oncogene, GTPase a. (189 aa)
ncbp2Nuclear cap-binding protein subunit 2; Component of the cap-binding complex (CBC), which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense- mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U [...] (164 aa)
LOC101155126Fibroblast growth factor receptor. (740 aa)
frs2Fibroblast growth factor receptor substrate 2b. (526 aa)
gtf2f1Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family. (534 aa)
FGF6-2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
LOC101159420Lactase-like a; Belongs to the glycosyl hydrolase 1 family. (474 aa)
LOC101158476Cbl proto-oncogene C, E3 ubiquitin protein ligase. (557 aa)
fgf20aFibroblast growth factor; Belongs to the heparin-binding growth factors family. (252 aa)
fgf8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (214 aa)
fgfbp3Fibroblast growth factor binding protein 3. (285 aa)
gab1GRB2-associated binding protein 1. (795 aa)
ptbp1Polypyrimidine tract binding protein 1a. (577 aa)
fgf10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (250 aa)
fndc3aFibronectin type III domain containing 3A. (1244 aa)
LOC101157091PH domain-containing protein. (761 aa)
FGFRL1Fibroblast growth factor receptor like 1. (540 aa)
LOC101162905Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (369 aa)
polr2hDNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. (150 aa)
fgf18Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family. (210 aa)
LOC105358735Sprouty related EVH1 domain containing 2a. (430 aa)
fgf5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
rps27aRibosomal protein S27a. (195 aa)
polr2aDNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1966 aa)
LctLactase. (1891 aa)
LOC101164480Tyrosine-protein kinase. (551 aa)
CSDE1Cold shock domain containing E1, RNA-binding. (875 aa)
anos1Uncharacterized protein. (696 aa)
LOC101164556Polypeptide N-acetylgalactosaminyltransferase. (621 aa)
ptbp2Polypyrimidine tract binding protein 2. (523 aa)
flrt3Fibronectin leucine rich transmembrane 3. (650 aa)
ENSORLP00000033909annotation not available (346 aa)
ENSORLP00000032568Fibroblast growth factor binding protein 1b. (196 aa)
krasGTPase KRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (By similarity). Plays an important role in the regulation of cell proliferation. (189 aa)
esrp1Epithelial splicing regulatory protein 1. (742 aa)
fgf19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
fgf4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (188 aa)
fgf3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (245 aa)
ppp2caSerine/threonine-protein phosphatase. (309 aa)
Fgf1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (159 aa)
LOC101174825Fibroblast growth factor receptor substrate 3. (608 aa)
fgf7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (205 aa)
SPRED2Sprouty related EVH1 domain containing 2. (464 aa)
LOC101155125Uncharacterized protein. (386 aa)
Your Current Organism:
Oryzias latipes
NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka
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