(16 nodes) Androgen biosynthesis network (Oryzias latipes)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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Known Interactions

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Predicted Interactions

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Your Input:
	LOC101163971	Hydroxysteroid (17-beta) dehydrogenase 12a; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (330 aa)
	LOC101156869	3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. (253 aa)
	LOC101164777	Uncharacterized protein. (265 aa)
	LOC101160884	Hydroxysteroid (17-beta) dehydrogenase 12b; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (319 aa)
	hsd17b3	Hydroxysteroid (17-beta) dehydrogenase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (349 aa)
	pomc	Proopiomelanocortin. (212 aa)
	LOC100125532	3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. (294 aa)
	cyp17	Steroid 17-alpha-hydroxylase/17,20 lyase; Conversion of pregnenolone and progesterone to their 17- alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction; Belongs to the cytochrome P450 family. (595 aa)
	hsdl1	Hydroxysteroid dehydrogenase like 1. (312 aa)
	H2MJ22_ORYLA	Uncharacterized protein. (214 aa)
	srd5a1	3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. (264 aa)
	3bhsd	3Beta_HSD domain-containing protein; Belongs to the 3-beta-HSD family. (374 aa)
	LOC101165994	20beta-hydroxysteroid dehydrogenase type2; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (312 aa)
	lhb	Luteinizing hormone, beta polypeptide. (146 aa)
	cyp17a2	Cytochrome P450 family 17 polypeptide 2; Belongs to the cytochrome P450 family. (521 aa)
	srd5a3	Steroid 5 alpha-reductase 3. (310 aa)

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
3bhsd	LOC100125532	ENSORLP00000010780	ENSORLP00000029093	3Beta_HSD domain-containing protein; Belongs to the 3-beta-HSD family.	3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology.	0.909
3bhsd	LOC101156869	ENSORLP00000010780	ENSORLP00000045739	3Beta_HSD domain-containing protein; Belongs to the 3-beta-HSD family.	3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology.	0.909
3bhsd	cyp17	ENSORLP00000010780	ENSORLP00000023956	3Beta_HSD domain-containing protein; Belongs to the 3-beta-HSD family.	Steroid 17-alpha-hydroxylase/17,20 lyase; Conversion of pregnenolone and progesterone to their 17- alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction; Belongs to the cytochrome P450 family.	0.975
3bhsd	cyp17a2	ENSORLP00000010780	ENSORLP00000002785	3Beta_HSD domain-containing protein; Belongs to the 3-beta-HSD family.	Cytochrome P450 family 17 polypeptide 2; Belongs to the cytochrome P450 family.	0.968
3bhsd	hsd17b3	ENSORLP00000010780	ENSORLP00000040545	3Beta_HSD domain-containing protein; Belongs to the 3-beta-HSD family.	Hydroxysteroid (17-beta) dehydrogenase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.944
3bhsd	srd5a1	ENSORLP00000010780	ENSORLP00000017992	3Beta_HSD domain-containing protein; Belongs to the 3-beta-HSD family.	3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology.	0.912
H2MJ22_ORYLA	lhb	ENSORLP00000018656	ENSORLP00000004424	Uncharacterized protein.	Luteinizing hormone, beta polypeptide.	0.416
LOC100125532	3bhsd	ENSORLP00000029093	ENSORLP00000010780	3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology.	3Beta_HSD domain-containing protein; Belongs to the 3-beta-HSD family.	0.909
LOC100125532	LOC101156869	ENSORLP00000029093	ENSORLP00000045739	3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology.	3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology.	0.902
LOC100125532	cyp17	ENSORLP00000029093	ENSORLP00000023956	3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology.	Steroid 17-alpha-hydroxylase/17,20 lyase; Conversion of pregnenolone and progesterone to their 17- alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction; Belongs to the cytochrome P450 family.	0.909
LOC100125532	cyp17a2	ENSORLP00000029093	ENSORLP00000002785	3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology.	Cytochrome P450 family 17 polypeptide 2; Belongs to the cytochrome P450 family.	0.909
LOC100125532	hsd17b3	ENSORLP00000029093	ENSORLP00000040545	3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology.	Hydroxysteroid (17-beta) dehydrogenase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.924
LOC100125532	srd5a1	ENSORLP00000029093	ENSORLP00000017992	3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology.	3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology.	0.906
LOC101156869	3bhsd	ENSORLP00000045739	ENSORLP00000010780	3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology.	3Beta_HSD domain-containing protein; Belongs to the 3-beta-HSD family.	0.909
LOC101156869	LOC100125532	ENSORLP00000045739	ENSORLP00000029093	3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology.	3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology.	0.902
LOC101156869	cyp17	ENSORLP00000045739	ENSORLP00000023956	3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology.	Steroid 17-alpha-hydroxylase/17,20 lyase; Conversion of pregnenolone and progesterone to their 17- alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction; Belongs to the cytochrome P450 family.	0.909
LOC101156869	cyp17a2	ENSORLP00000045739	ENSORLP00000002785	3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology.	Cytochrome P450 family 17 polypeptide 2; Belongs to the cytochrome P450 family.	0.909
LOC101156869	hsd17b3	ENSORLP00000045739	ENSORLP00000040545	3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology.	Hydroxysteroid (17-beta) dehydrogenase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.924
LOC101156869	srd5a1	ENSORLP00000045739	ENSORLP00000017992	3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology.	3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology.	0.905
LOC101160884	LOC101163971	ENSORLP00000040712	ENSORLP00000001758	Hydroxysteroid (17-beta) dehydrogenase 12b; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Hydroxysteroid (17-beta) dehydrogenase 12a; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.902