STRINGSTRING
fgf19 fgf19 fgf4 fgf4 fgf3 fgf3 ppp2ca ppp2ca traf6 traf6 INSC INSC LOC101174244 LOC101174244 Fgf1 Fgf1 erbb3 erbb3 FGF13 FGF13 LOC101165892 LOC101165892 LOC101166137 LOC101166137 LOC101158789 LOC101158789 fgf7 fgf7 lrrc40 lrrc40 pik3r1 pik3r1 gab2 gab2 irak4 irak4 LOC101169984 LOC101169984 kl kl LOC101164953 LOC101164953 klb klb pdgfrb pdgfrb LOC101174851 LOC101174851 LOC101154847 LOC101154847 ppp2r5b ppp2r5b LOC101174230 LOC101174230 LOC101161650 LOC101161650 fgf16 fgf16 pten pten H2LP85_ORYLA H2LP85_ORYLA SRC SRC ppp4r1 ppp4r1 strn4 strn4 LOC101167061 LOC101167061 LOC101172978 LOC101172978 PHLPP2 PHLPP2 LOC101171182 LOC101171182 pdgfa pdgfa PIK3CA PIK3CA LOC101168152 LOC101168152 LOC101157257 LOC101157257 hgf hgf myd88 myd88 LOC101171139 LOC101171139 strn3 strn3 LOC101155144 LOC101155144 fndc3b fndc3b LOC101159747 LOC101159747 ppp2r5a ppp2r5a fgfr2 fgfr2 LOC101165149 LOC101165149 LOC101162944 LOC101162944 LOC100049521 LOC100049521 pik3ap1 pik3ap1 LOC101155451 LOC101155451 fgfr1 fgfr1 grb2 grb2 LOC101173218 LOC101173218 LOC101166419 LOC101166419 FGF6 FGF6 H2MLW1_ORYLA H2MLW1_ORYLA fgf23 fgf23 erbb4 erbb4 fnbp4 fnbp4 LOC101169535 LOC101169535 H2MR50_ORYLA H2MR50_ORYLA akt1 akt1 LOC101166990 LOC101166990 H2MSU3_ORYLA H2MSU3_ORYLA egfr egfr esr2 esr2 fgfr3 fgfr3 irs2 irs2 esr2-2 esr2-2 LOC101173107 LOC101173107 LCT LCT H2MVE2_ORYLA H2MVE2_ORYLA LOC101173752 LOC101173752 LOC101168764 LOC101168764 met met pdgfra pdgfra PTEN PTEN fgf20b fgf20b LOC101169753 LOC101169753 LOC101156096 LOC101156096 LOC101163728 LOC101163728 pdgfb pdgfb ENSORLP00000027361 ENSORLP00000027361 LOC101163663 LOC101163663 ppp2cb ppp2cb Kitlg Kitlg LOC101159516 LOC101159516 lctl lctl kit kit LOC101155126 LOC101155126 LOC101174326 LOC101174326 frs2 frs2 LOC101172253 LOC101172253 flt3 flt3 FGF6-2 FGF6-2 LOC101159420 LOC101159420 il1rap il1rap pik3cd pik3cd LOC101163116 LOC101163116 LOC101166254 LOC101166254 LOC105355004 LOC105355004 fgf20a fgf20a fgf8 fgf8 esr1 esr1 cd276 cd276 LOC101166403 LOC101166403 gab1 gab1 LOC101167011 LOC101167011 fgf10 fgf10 fndc3a fndc3a LOC101157091 LOC101157091 LOC101166698 LOC101166698 LOC101166954 LOC101166954 PPP2R5C PPP2R5C pip4k2a pip4k2a LOC101162905 LOC101162905 lck lck relch relch pip5k1c pip5k1c fam102b fam102b STRN STRN fgf18 fgf18 LOC101164582 LOC101164582 fgf5 fgf5 LOC101173168 LOC101173168 LOC101155207 LOC101155207 Lct Lct LOC101166855 LOC101166855 ppp2r5d ppp2r5d LOC101164480 LOC101164480 morn2 morn2 LOC101162468 LOC101162468 LOC101172604 LOC101172604 LOC101155981 LOC101155981 LOC101160461 LOC101160461 LOC101174984 LOC101174984 pik3cb pik3cb egf egf LOC100125446 LOC100125446 LOC105355769 LOC105355769 pik3r3 pik3r3 LOC101165379 LOC101165379 PIP4K2B PIP4K2B LOC101169066 LOC101169066 LOC105356386 LOC105356386 LOC101162992 LOC101162992 fam102a fam102a ENSORLP00000029856 ENSORLP00000029856 LOC101157019 LOC101157019
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
fgf19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
fgf4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (188 aa)
fgf3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (245 aa)
ppp2caSerine/threonine-protein phosphatase. (309 aa)
traf6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (569 aa)
INSCINSC spindle orientation adaptor protein. (545 aa)
LOC101174244Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
Fgf1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (159 aa)
erbb3Protein kinase domain-containing protein. (1411 aa)
FGF13Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
LOC101165892EGF-like domain-containing protein. (162 aa)
LOC101166137EGF-like domain-containing protein. (154 aa)
LOC101158789Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (251 aa)
fgf7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (205 aa)
lrrc40Leucine rich repeat containing 40. (595 aa)
pik3r1Phosphoinositide-3-kinase, regulatory subunit 1 (alpha). (728 aa)
gab2GRB2-associated binding protein 2. (674 aa)
irak4Interleukin-1 receptor-associated kinase 4. (457 aa)
LOC101169984Receptor protein-tyrosine kinase. (1191 aa)
klKlotho. (975 aa)
LOC101164953Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (954 aa)
klbKlotho beta. (1045 aa)
pdgfrbPlatelet-derived growth factor receptor, beta polypeptide; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1112 aa)
LOC101174851Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
LOC101154847Uncharacterized protein. (212 aa)
ppp2r5bSerine/threonine protein phosphatase 2A regulatory subunit; Belongs to the phosphatase 2A regulatory subunit. (520 aa)
LOC101174230Receptor protein-tyrosine kinase. (1292 aa)
LOC101161650Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (157 aa)
fgf16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (217 aa)
ptenPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (437 aa)
H2LP85_ORYLARas homolog gene family, member Gd. (120 aa)
SRCTyrosine-protein kinase. (544 aa)
ppp4r1WRNPLPNID domain-containing protein. (969 aa)
strn4Striatin, calmodulin binding protein 4. (783 aa)
LOC101167061Protein phosphatase 2, regulatory subunit A, beta b. (589 aa)
LOC101172978Erb-b2 receptor tyrosine kinase 3b. (1376 aa)
PHLPP2PH domain and leucine rich repeat protein phosphatase 2. (1435 aa)
LOC101171182Crystallin, beta B1, like 3; Belongs to the beta/gamma-crystallin family. (209 aa)
pdgfaPlatelet-derived growth factor alpha polypeptide b; Belongs to the PDGF/VEGF growth factor family. (227 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
LOC101168152Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
LOC101157257Uncharacterized protein. (548 aa)
hgfHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (712 aa)
myd88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (288 aa)
LOC101171139Platelet-derived growth factor alpha polypeptide a; Belongs to the PDGF/VEGF growth factor family. (199 aa)
strn3Striatin, calmodulin binding protein 3. (695 aa)
LOC101155144Uncharacterized protein. (466 aa)
fndc3bFibronectin type III domain containing 3Ba. (1209 aa)
LOC101159747Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (389 aa)
ppp2r5aSerine/threonine protein phosphatase 2A regulatory subunit; Belongs to the phosphatase 2A regulatory subunit. (509 aa)
fgfr2Fibroblast growth factor receptor. (832 aa)
LOC101165149Platelet-derived growth factor beta polypeptide b; Belongs to the PDGF/VEGF growth factor family. (510 aa)
LOC101162944Ras homolog family member Gb. (191 aa)
LOC100049521Fibroblast growth factor receptor 4. (1075 aa)
pik3ap1Phosphoinositide-3-kinase adaptor protein 1. (915 aa)
LOC101155451Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (482 aa)
fgfr1Fibroblast growth factor receptor. (833 aa)
grb2Growth factor receptor-bound protein 2b. (218 aa)
LOC101173218Phosphatidylinositol-5-phosphate 4-kinase, type II, gamma b. (408 aa)
LOC101166419C2 NT-type domain-containing protein. (369 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (198 aa)
H2MLW1_ORYLAUncharacterized protein. (125 aa)
fgf23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (263 aa)
erbb4Receptor protein-tyrosine kinase. (1375 aa)
fnbp4Formin binding protein 4. (843 aa)
LOC101169535Phosphatidylinositol-5-phosphate 4-kinase, type II, gamma a. (416 aa)
H2MR50_ORYLAUncharacterized protein. (156 aa)
akt1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (496 aa)
LOC101166990PH domain and leucine rich repeat protein phosphatase 1. (1757 aa)
H2MSU3_ORYLAUncharacterized protein. (420 aa)
egfrReceptor protein-tyrosine kinase. (1185 aa)
esr2Uncharacterized protein. (574 aa)
fgfr3Fibroblast growth factor receptor. (820 aa)
irs2Insulin receptor substrate 2b. (1081 aa)
esr2-2Uncharacterized protein. (541 aa)
LOC101173107Serine/threonine protein phosphatase 2A regulatory subunit; Belongs to the phosphatase 2A regulatory subunit. (478 aa)
LCTLactase. (1849 aa)
H2MVE2_ORYLAProtein phosphatase 4, regulatory subunit 4. (726 aa)
LOC101173752IGv domain-containing protein. (224 aa)
LOC101168764Tyrosine-protein kinase receptor. (1375 aa)
metMET proto-oncogene, receptor tyrosine kinase. (1403 aa)
pdgfraPlatelet-derived growth factor receptor, alpha polypeptide; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1460 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (415 aa)
fgf20bFibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
LOC101169753Serine/threonine protein phosphatase 2A regulatory subunit; Belongs to the phosphatase 2A regulatory subunit. (609 aa)
LOC101156096Heparin-binding EGF-like growth factor a. (233 aa)
LOC101163728Uncharacterized protein. (409 aa)
pdgfbPlatelet-derived growth factor beta polypeptide a; Belongs to the PDGF/VEGF growth factor family. (553 aa)
ENSORLP00000027361Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (250 aa)
LOC101163663Phosphatidylinositol-4-phosphate 5-kinase, type I, beta b. (543 aa)
ppp2cbSerine/threonine-protein phosphatase. (309 aa)
KitlgKit ligand a. (233 aa)
LOC101159516Neuregulin 2b. (712 aa)
lctlLactase-like b; Belongs to the glycosyl hydrolase 1 family. (585 aa)
kitUncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (994 aa)
LOC101155126Fibroblast growth factor receptor. (740 aa)
LOC101174326Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (233 aa)
frs2Fibroblast growth factor receptor substrate 2b. (526 aa)
LOC101172253Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
flt3Fms-related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (997 aa)
FGF6-2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
LOC101159420Lactase-like a; Belongs to the glycosyl hydrolase 1 family. (474 aa)
il1rapUncharacterized protein. (667 aa)
pik3cdPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1039 aa)
LOC101163116Neuregulin 3b. (763 aa)
LOC101166254Tyrosine-protein kinase receptor. (1387 aa)
LOC105355004Phosphatidylinositol-4-phosphate 5-kinase, type I, alpha, a. (573 aa)
fgf20aFibroblast growth factor; Belongs to the heparin-binding growth factors family. (252 aa)
fgf8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (214 aa)
esr1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (634 aa)
cd276CD276 molecule. (302 aa)
LOC101166403Phosphatidylinositol-4-phosphate 5-kinase, type I, beta a. (505 aa)
gab1GRB2-associated binding protein 1. (795 aa)
LOC101167011Tyrosine-protein kinase. (526 aa)
fgf10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (250 aa)
fndc3aFibronectin type III domain containing 3A. (1244 aa)
LOC101157091PH domain-containing protein. (761 aa)
LOC101166698Protein kinase domain-containing protein. (721 aa)
LOC101166954PPM-type phosphatase domain-containing protein. (1675 aa)
PPP2R5CSerine/threonine protein phosphatase 2A regulatory subunit; Belongs to the phosphatase 2A regulatory subunit. (567 aa)
pip4k2aPhosphatidylinositol-5-phosphate 4-kinase, type II, alpha a. (443 aa)
LOC101162905Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (369 aa)
lckTyrosine-protein kinase. (498 aa)
relchRAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (1209 aa)
pip5k1cPhosphatidylinositol-4-phosphate 5-kinase, type I, gamma a. (722 aa)
fam102bFamily with sequence similarity 102 member Bb. (378 aa)
STRNWD_REPEATS_REGION domain-containing protein. (772 aa)
fgf18Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family. (210 aa)
LOC101164582Neuregulin 2a. (711 aa)
fgf5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
LOC101173168Phosphatidylinositol-4-phosphate 5-kinase, type I, alpha, b. (610 aa)
LOC101155207Betacellulin, epidermal growth factor family member. (183 aa)
LctLactase. (1891 aa)
LOC101166855Transforming growth factor, alpha. (254 aa)
ppp2r5dSerine/threonine protein phosphatase 2A regulatory subunit; Belongs to the phosphatase 2A regulatory subunit. (597 aa)
LOC101164480Tyrosine-protein kinase. (551 aa)
morn2MORN repeat containing 2. (150 aa)
LOC101162468Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
LOC101172604Thioesterase superfamily member 4. (246 aa)
LOC101155981Striatin, calmodulin binding protein. (780 aa)
LOC101160461EGF-like domain-containing protein. (607 aa)
LOC101174984Insulin receptor substrate 2a. (1049 aa)
pik3cbPhosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1078 aa)
egfEpidermal growth factor. (966 aa)
LOC100125446Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (226 aa)
LOC105355769EGF-like domain-containing protein. (520 aa)
pik3r3Phosphoinositide-3-kinase, regulatory subunit 3b (gamma). (719 aa)
LOC101165379Receptor protein-tyrosine kinase. (1494 aa)
PIP4K2BPhosphatidylinositol-5-phosphate 4-kinase type 2 beta. (412 aa)
LOC101169066Phosphatidylinositol-4-phosphate 5-kinase, type I, gamma b. (785 aa)
LOC105356386DBB domain-containing protein. (589 aa)
LOC101162992Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (223 aa)
fam102aFamily with sequence similarity 102 member Aa. (384 aa)
ENSORLP00000029856Lactase. (1831 aa)
LOC101157019Tyrosine-protein kinase. (537 aa)
Your Current Organism:
Oryzias latipes
NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka
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