STRINGSTRING
cltcl1 cltcl1 arpc2 arpc2 LOC101157122 LOC101157122 LOC101155832 LOC101155832 cfl1 cfl1 LOC101156166 LOC101156166 actr2 actr2 NCSTN NCSTN LOC101160196 LOC101160196 LOC101158395 LOC101158395 LOC101162164 LOC101162164 LOC101163953 LOC101163953 LOC101172801 LOC101172801 LOC101164834 LOC101164834 LOC101163273 LOC101163273 LOC101171316 LOC101171316 LOC101156802 LOC101156802 LOC101164658 LOC101164658 mmp9 mmp9 psenen psenen SRC SRC ap2s1 ap2s1 PAK3 PAK3 LOC101157161 LOC101157161 epha4 epha4 arpc1a arpc1a LOC101168921 LOC101168921 arpc5 arpc5 rasa1 rasa1 epha10 epha10 arpc3 arpc3 LOC101169846 LOC101169846 H2M6A2_ORYLA H2M6A2_ORYLA YES1 YES1 hras hras LOC101171817 LOC101171817 epha5 epha5 fndc3b fndc3b LOC101164501 LOC101164501 LOC101167394 LOC101167394 CDC42 CDC42 LOC101166510 LOC101166510 LOC101157554 LOC101157554 was was ap2m1 ap2m1 LOC101169874 LOC101169874 LOC101171688 LOC101171688 LOC101160266 LOC101160266 epha3 epha3 LOC101173092 LOC101173092 FMN1 FMN1 ap2a1 ap2a1 LOC101165974 LOC101165974 LOC101169951 LOC101169951 LOC101158771 LOC101158771 LOC101173070 LOC101173070 LOC101155523 LOC101155523 LOC101162321 LOC101162321 epha7 epha7 LOC101159650 LOC101159650 LOC101156311 LOC101156311 LOC101158510 LOC101158510 psen2 psen2 clta clta ephb3 ephb3 grin2b grin2b pak1 pak1 LOC101175170 LOC101175170 LOC101160423 LOC101160423 LOC101167426 LOC101167426 efna1 efna1 LOC101174773 LOC101174773 LOC101174454 LOC101174454 ENSORLP00000029055 ENSORLP00000029055 LOC101173083 LOC101173083 LOC101157019 LOC101157019 VAV1 VAV1 dnm1 dnm1 LOC101175360 LOC101175360 vav2 vav2 LOC111947159 LOC111947159 ngef ngef LOC101154942 LOC101154942 cltc cltc epha8 epha8 LOC111948169 LOC111948169 LOC101164400 LOC101164400 LOC101169249 LOC101169249 LOC101154874 LOC101154874 LOC101164480 LOC101164480 LOC101159909 LOC101159909 ENSORLP00000036561 ENSORLP00000036561 LOC101172697 LOC101172697 LOC101155840 LOC101155840 LOC101159957 LOC101159957 VAV3 VAV3 LOC101159120 LOC101159120 LOC101168573 LOC101168573 EPHA6 EPHA6 pak2 pak2 LOC101173416 LOC101173416 EFNA5 EFNA5 fndc3a fndc3a mmp2 mmp2 LOC101167011 LOC101167011 wasl wasl cltb cltb LOC101155777 LOC101155777 efna3 efna3 LOC101174366 LOC101174366 LOC101169622 LOC101169622 ephb4 ephb4 LOC101165761 LOC101165761 LOC101160624 LOC101160624 ENSORLP00000043979 ENSORLP00000043979 efnb1 efnb1 fmn2 fmn2 LOC101154844 LOC101154844 rock1 rock1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
cltcl1Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1658 aa)
arpc2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (304 aa)
LOC101157122Actin related protein 2/3 complex, subunit 4. (282 aa)
LOC101155832Uncharacterized protein; Belongs to the actin family. (418 aa)
cfl1Cofilin 1; Belongs to the actin-binding proteins ADF family. (167 aa)
LOC101156166Syndecan binding protein (syntenin) 2. (317 aa)
actr2Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (394 aa)
NCSTNNicastrin. (677 aa)
LOC101160196Ephrin-B3a; Belongs to the ephrin family. (340 aa)
LOC101158395Actin related protein 3; Belongs to the actin family. (418 aa)
LOC101162164Actin related protein 3B; Belongs to the actin family. (429 aa)
LOC101163953Glutamate receptor, ionotropic, N-methyl D-aspartate 2B, genome duplicate b. (1552 aa)
LOC101172801Ephrin RBD domain-containing protein; Belongs to the ephrin family. (342 aa)
LOC101164834FH2 domain-containing protein. (377 aa)
LOC101163273Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (91 aa)
LOC101171316Eph receptor A6. (1002 aa)
LOC101156802Rho guanine nucleotide exchange factor (GEF) 7b. (859 aa)
LOC101164658Uncharacterized protein. (242 aa)
mmp9Uncharacterized protein. (690 aa)
psenenPresenilin enhancer, gamma-secretase subunit. (101 aa)
SRCTyrosine-protein kinase. (544 aa)
ap2s1AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (142 aa)
PAK3Non-specific serine/threonine protein kinase. (590 aa)
LOC101157161Zgc:101810; Belongs to the actin family. (394 aa)
epha4Eph receptor A4, like. (990 aa)
arpc1aActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (365 aa)
LOC101168921Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (410 aa)
arpc5Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (154 aa)
rasa1RAS p21 protein activator (GTPase activating protein) 1a. (1055 aa)
epha10Uncharacterized protein. (1021 aa)
arpc3Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (179 aa)
LOC101169846Uncharacterized protein. (990 aa)
H2M6A2_ORYLAIntersectin 1 (SH3 domain protein). (608 aa)
YES1Tyrosine-protein kinase. (550 aa)
hrasHRas proto-oncogene, GTPase a. (189 aa)
LOC101171817Fibronectin type-III domain-containing protein. (665 aa)
epha5Uncharacterized protein. (1007 aa)
fndc3bFibronectin type III domain containing 3Ba. (1209 aa)
LOC101164501ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (159 aa)
LOC101167394Receptor protein-tyrosine kinase. (1020 aa)
CDC42Cell division cycle 42. (191 aa)
LOC101166510Rho guanine nucleotide exchange factor (GEF) 7a. (779 aa)
LOC101157554Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1677 aa)
wasWASP actin nucleation promoting factor a. (561 aa)
ap2m1AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...] (442 aa)
LOC101169874Glutamate receptor, ionotropic, N-methyl D-aspartate 1a. (901 aa)
LOC101171688AP complex subunit beta. (953 aa)
LOC101160266Uncharacterized protein. (1078 aa)
epha3Eph receptor A3. (990 aa)
LOC101173092EPH receptor B1. (1007 aa)
FMN1Formin 1. (1281 aa)
ap2a1AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (983 aa)
LOC101165974Eph receptor B2b. (988 aa)
LOC101169951Uncharacterized protein. (330 aa)
LOC101158771Zgc:86896. (356 aa)
LOC101173070Uncharacterized protein. (369 aa)
LOC101155523Uncharacterized protein. (375 aa)
LOC101162321Tyrosine-protein kinase. (547 aa)
epha7Eph receptor A7. (992 aa)
LOC101159650APH1B gamma secretase subunit. (258 aa)
LOC101156311Eph receptor B2a. (985 aa)
LOC101158510Eph receptor A2 b. (1003 aa)
psen2Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (421 aa)
cltaClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (226 aa)
ephb3Receptor protein-tyrosine kinase. (1013 aa)
grin2bUncharacterized protein. (1703 aa)
pak1Non-specific serine/threonine protein kinase. (571 aa)
LOC101175170Uncharacterized protein. (939 aa)
LOC101160423Ephrin-A3a; Belongs to the ephrin family. (224 aa)
LOC101167426Actin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (381 aa)
efna1Ephrin-A1b; Belongs to the ephrin family. (263 aa)
LOC101174773Ephrin RBD domain-containing protein; Belongs to the ephrin family. (196 aa)
LOC101174454Uncharacterized protein. (191 aa)
ENSORLP00000029055Protein kinase domain-containing protein. (87 aa)
LOC101173083T cell lymphoma invasion and metastasis 1a. (1657 aa)
LOC101157019Tyrosine-protein kinase. (537 aa)
VAV1Vav guanine nucleotide exchange factor 1. (902 aa)
dnm1Dynamin 1a; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (861 aa)
LOC101175360Ephrin-A2a; Belongs to the ephrin family. (238 aa)
vav2Vav 2 guanine nucleotide exchange factor. (922 aa)
LOC111947159Fibronectin type-III domain-containing protein. (667 aa)
ngefNeuronal guanine nucleotide exchange factor. (589 aa)
LOC101154942Eph receptor A2 a. (974 aa)
cltcClathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1695 aa)
epha8Uncharacterized protein. (1020 aa)
LOC111948169Ephrin-A1a; Belongs to the ephrin family. (222 aa)
LOC101164400Uncharacterized protein. (191 aa)
LOC101169249Non-specific serine/threonine protein kinase. (514 aa)
LOC101154874Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (862 aa)
LOC101164480Tyrosine-protein kinase. (551 aa)
LOC101159909Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. (184 aa)
ENSORLP00000036561Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (91 aa)
LOC101172697Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1401 aa)
LOC101155840Ephrin RBD domain-containing protein; Belongs to the ephrin family. (217 aa)
LOC101159957Cofilin 2 (muscle); Belongs to the actin-binding proteins ADF family. (166 aa)
VAV3Vav guanine nucleotide exchange factor 3. (864 aa)
LOC101159120Ephrin RBD domain-containing protein; Belongs to the ephrin family. (229 aa)
LOC101168573Eph receptor A4b. (1007 aa)
EPHA6EPH receptor A6. (1015 aa)
pak2Non-specific serine/threonine protein kinase. (532 aa)
LOC101173416Uncharacterized protein. (566 aa)
EFNA5Ephrin A5; Belongs to the ephrin family. (229 aa)
fndc3aFibronectin type III domain containing 3A. (1244 aa)
mmp2Uncharacterized protein. (657 aa)
LOC101167011Tyrosine-protein kinase. (526 aa)
waslUncharacterized protein. (519 aa)
cltbClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (228 aa)
LOC101155777Uncharacterized protein. (372 aa)
efna3Ephrin-A3b; Belongs to the ephrin family. (221 aa)
LOC101174366T cell lymphoma invasion and metastasis 1b. (1604 aa)
LOC101169622Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (209 aa)
ephb4Eph receptor B4a. (985 aa)
LOC101165761Eph receptor B3a. (926 aa)
LOC101160624Vav 3 guanine nucleotide exchange factor b. (904 aa)
ENSORLP00000043979Uncharacterized protein. (193 aa)
efnb1Ephrin-B1; Belongs to the ephrin family. (330 aa)
fmn2FH2 domain-containing protein. (1391 aa)
LOC101154844Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (410 aa)
rock1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1364 aa)
Your Current Organism:
Oryzias latipes
NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka
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