(53 nodes) G-protein beta:gamma signalling network (Oryzias latipes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	mfsd6	Major facilitator superfamily domain containing 6a. (731 aa)
	LOC101164658	Uncharacterized protein. (242 aa)
	LOC101161831	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
	LOC100049335	ZP domain-containing protein. (365 aa)
	GNG4	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
	GNG5	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (66 aa)
	LOC101161757	ZP domain-containing protein. (372 aa)
	LOC110015484	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
	LOC101155207-2	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
	ol-gb1	WD_REPEATS_REGION domain-containing protein. (369 aa)
	plcb2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1248 aa)
	LOC101157701	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
	LOC110016922	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
	gng8	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
	LOC101162468	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	gng3	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
	LOC101171292	Guanine nucleotide binding protein (G protein), gamma 7. (123 aa)
	LOC101164400	Uncharacterized protein. (191 aa)
	mfsd6l	Major facilitator superfamily domain containing 6-like. (587 aa)
	LOC101175365	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1161 aa)
	arhgef6	Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6. (764 aa)
	LOC111946430	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (96 aa)
	LOC101164755	ZP domain-containing protein. (459 aa)
	gnb4	Guanine nucleotide binding protein (G protein), beta polypeptide 4b. (340 aa)
	LOC101174454	Uncharacterized protein. (191 aa)
	pak1	Non-specific serine/threonine protein kinase. (571 aa)
	akt1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (496 aa)
	LOC101168467	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (67 aa)
	LOC100049336	ZPC domain containing protein 4. (459 aa)
	PIK3R5	Phosphoinositide-3-kinase regulatory subunit 5. (861 aa)
	LOC101155451	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (482 aa)
	LOC101156727	Guanine nucleotide binding protein (G protein), beta 5b. (395 aa)
	gnb3	Guanine nucleotide binding protein (G protein), beta polypeptide 3a. (340 aa)
	CDC42	Cell division cycle 42. (191 aa)
	LOC101155257	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (71 aa)
	LOC100049337	ZP domain-containing protein. (498 aa)
	PLCB1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1242 aa)
	pik3cg	Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1121 aa)
	gng2	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (78 aa)
	LOC101165947	Guanine nucleotide binding protein (G protein), gamma 13a. (67 aa)
	LOC101175500	Guanine nucleotide binding protein (G protein), beta polypeptide 2. (340 aa)
	pdpk1	3-phosphoinositide dependent protein kinase 1b. (568 aa)
	PAK3	Non-specific serine/threonine protein kinase. (590 aa)
	ol-gb	WD_REPEATS_REGION domain-containing protein. (342 aa)
	gnb5	Guanine nucleotide binding protein (G protein), beta 5a. (364 aa)
	LOC100049529	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1237 aa)
	LOC101174851	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	H2LGY1_ORYLA	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
	LOC101168199	WD_REPEATS_REGION domain-containing protein. (340 aa)
	pik3r5	Phosphoinositide-3-kinase, regulatory subunit 5. (883 aa)
	PIK3R6	Phosphoinositide-3-kinase regulatory subunit 6. (774 aa)
	LOC101159013	Si:rp71-17i16.5; Belongs to the PI3/PI4-kinase family. (1106 aa)
	LOC101174244	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDC42	GNG5	ENSORLP00000015084	ENSORLP00000041849	Cell division cycle 42.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.490
CDC42	H2LGY1_ORYLA	ENSORLP00000015084	ENSORLP00000005234	Cell division cycle 42.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.495
CDC42	LOC101155451	ENSORLP00000015084	ENSORLP00000017781	Cell division cycle 42.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.418
CDC42	LOC101156727	ENSORLP00000015084	ENSORLP00000016014	Cell division cycle 42.	Guanine nucleotide binding protein (G protein), beta 5b.	0.557
CDC42	LOC101161831	ENSORLP00000015084	ENSORLP00000045430	Cell division cycle 42.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.444
CDC42	LOC101162468	ENSORLP00000015084	ENSORLP00000035304	Cell division cycle 42.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.418
CDC42	LOC101168199	ENSORLP00000015084	ENSORLP00000004503	Cell division cycle 42.	WD_REPEATS_REGION domain-containing protein.	0.470
CDC42	LOC101171292	ENSORLP00000015084	ENSORLP00000035205	Cell division cycle 42.	Guanine nucleotide binding protein (G protein), gamma 7.	0.444
CDC42	LOC101174244	ENSORLP00000015084	ENSORLP00000001785	Cell division cycle 42.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.418
CDC42	LOC101174851	ENSORLP00000015084	ENSORLP00000006529	Cell division cycle 42.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.418
CDC42	LOC101175500	ENSORLP00000015084	ENSORLP00000009914	Cell division cycle 42.	Guanine nucleotide binding protein (G protein), beta polypeptide 2.	0.470
CDC42	LOC110016922	ENSORLP00000015084	ENSORLP00000035371	Cell division cycle 42.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.490
CDC42	PAK3	ENSORLP00000015084	ENSORLP00000008803	Cell division cycle 42.	Non-specific serine/threonine protein kinase.	0.960
CDC42	akt1	ENSORLP00000015084	ENSORLP00000021301	Cell division cycle 42.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.418
CDC42	arhgef6	ENSORLP00000015084	ENSORLP00000032471	Cell division cycle 42.	Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6.	0.710
CDC42	gnb4	ENSORLP00000015084	ENSORLP00000029397	Cell division cycle 42.	Guanine nucleotide binding protein (G protein), beta polypeptide 4b.	0.470
CDC42	gnb5	ENSORLP00000015084	ENSORLP00000006943	Cell division cycle 42.	Guanine nucleotide binding protein (G protein), beta 5a.	0.557
CDC42	gng3	ENSORLP00000015084	ENSORLP00000035224	Cell division cycle 42.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.490
CDC42	ol-gb1	ENSORLP00000015084	ENSORLP00000038107	Cell division cycle 42.	WD_REPEATS_REGION domain-containing protein.	0.470
CDC42	pak1	ENSORLP00000015084	ENSORLP00000027320	Cell division cycle 42.	Non-specific serine/threonine protein kinase.	0.960