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mdm2 mdm2 LOC101174468 LOC101174468 LOC101161464 LOC101161464 cacng4 cacng4 LOC101167340 LOC101167340 cacng2 cacng2 LOC101164162 LOC101164162 gria2 gria2 NSF NSF LOC101164872 LOC101164872 ap2a1 ap2a1 LOC101175340 LOC101175340 LOC101171688 LOC101171688 ap2m1 ap2m1 PRKCA PRKCA cacng3 cacng3 LOC101163507 LOC101163507 LOC101166717 LOC101166717 LOC101159746 LOC101159746 PRKCB PRKCB LOC101158221 LOC101158221 ap2s1 ap2s1 LOC101171999 LOC101171999 LOC101162269 LOC101162269 grip1 grip1 tspan7 tspan7 pick1 pick1 tspan6 tspan6 LOC101164921 LOC101164921 grip2 grip2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
mdm2MDM2 proto-oncogene. (498 aa)
LOC101174468N-ethylmaleimide-sensitive factor b. (745 aa)
LOC101161464Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (666 aa)
cacng4Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (330 aa)
LOC101167340Uncharacterized protein. (969 aa)
cacng2Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (322 aa)
LOC101164162Glutamate receptor, ionotropic, AMPA 1a. (921 aa)
gria2Uncharacterized protein. (897 aa)
NSFN-ethylmaleimide sensitive factor, vesicle fusing ATPase. (754 aa)
LOC101164872AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (920 aa)
ap2a1AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (983 aa)
LOC101175340Uncharacterized protein. (842 aa)
LOC101171688AP complex subunit beta. (953 aa)
ap2m1AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...] (442 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (709 aa)
cacng3Calcium voltage-gated channel auxiliary subunit gamma 3. (315 aa)
LOC101163507Glutamate receptor, ionotropic, AMPA 4a. (892 aa)
LOC101166717Glutamate receptor interacting protein 2a. (1081 aa)
LOC101159746Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (670 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (680 aa)
LOC101158221Glutamate receptor, ionotropic, AMPA 3a. (886 aa)
ap2s1AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (142 aa)
LOC101171999Glutamate ionotropic receptor AMPA type subunit 3. (882 aa)
LOC101162269Tetraspanin. (250 aa)
grip1Glutamate receptor interacting protein 1. (1163 aa)
tspan7Tetraspanin. (300 aa)
pick1Protein interacting with prkca 1. (421 aa)
tspan6Tetraspanin. (253 aa)
LOC101164921Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (704 aa)
grip2Glutamate receptor interacting protein 2b. (1178 aa)
Your Current Organism:
Oryzias latipes
NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka
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