STRINGSTRING
psmd13 psmd13 orc4 orc4 H2L3G9_ORYLA H2L3G9_ORYLA LOC101166216 LOC101166216 ccnd1 ccnd1 LOC101157953 LOC101157953 mcm7 mcm7 pole3 pole3 e2f1 e2f1 ppp2ca ppp2ca skp1 skp1 wee1 wee1 H2L6D0_ORYLA H2L6D0_ORYLA psma1 psma1 psmb4 psmb4 LOC101174244 LOC101174244 psma4 psma4 LOC101168468 LOC101168468 LOC101163574 LOC101163574 psmd8 psmd8 rbbp8nl rbbp8nl cdc45 cdc45 cul1 cul1 meiob meiob mcm2 mcm2 RPA1 RPA1 LOC101167568 LOC101167568 LOC101172332 LOC101172332 cdkn2d cdkn2d ccna1 ccna1 psmd14 psmd14 cdk6 cdk6 rpa1 rpa1 cdc7 cdc7 LOC101174851 LOC101174851 psmd5 psmd5 psmc5 psmc5 psmd9 psmd9 psma2 psma2 psme1 psme1 psmb9 psmb9 psmb9-like psmb9-like SRC SRC ppp4r1 ppp4r1 LOC101167061 LOC101167061 psmd1 psmd1 POLE POLE psmd6 psmd6 uba52 uba52 LOC101155046 LOC101155046 H2LYW2_ORYLA H2LYW2_ORYLA dbf4 dbf4 psmd2 psmd2 LOC101173089 LOC101173089 psmb2 psmb2 ccnh ccnh LOC101157629 LOC101157629 prim2 prim2 psma3 psma3 psmd7 psmd7 mcm5 mcm5 kxd1 kxd1 psmc3 psmc3 psmb1 psmb1 PPP2R3B PPP2R3B mcm6 mcm6 orc2 orc2 mybl2 mybl2 fndc3b fndc3b H2M970_ORYLA H2M970_ORYLA ubc ubc LOC101157461 LOC101157461 prim1 prim1 LOC101167467 LOC101167467 skp2 skp2 tfdp1 tfdp1 gmnn gmnn pole2 pole2 psme2 psme2 lin9 lin9 LOC101155451 LOC101155451 rpa2 rpa2 e2f2 e2f2 orc3 orc3 LOC101175566 LOC101175566 ccne2 ccne2 psmc6 psmc6 mcm9 mcm9 ccne1 ccne1 e2f4 e2f4 psmc1 psmc1 orc5 orc5 LOC101156733 LOC101156733 psma5 psma5 mcm3 mcm3 fnbp4 fnbp4 LOC101159588 LOC101159588 psmc4 psmc4 akt1 akt1 LOC101161792 LOC101161792 pole4 pole4 psmf1 psmf1 ppp2r3c ppp2r3c LOC101164754 LOC101164754 H2MVE2_ORYLA H2MVE2_ORYLA cdc25b cdc25b LOC101158678 LOC101158678 LOC101174330 LOC101174330 rbl1 rbl1 ccna2 ccna2 LOC101169671 LOC101169671 mcm10 mcm10 psme3 psme3 LOC111948194 LOC111948194 ppp2cb ppp2cb cdk2 cdk2 LOC110014991 LOC110014991 psmc2 psmc2 orc1 orc1 LOC101160207 LOC101160207 LOC101161318 LOC101161318 cdkn2b cdkn2b lin54 lin54 psmd12 psmd12 pola2 pola2 ENSORLP00000033513 ENSORLP00000033513 cdkn1b cdkn1b psmd10 psmd10 E2F3 E2F3 cdt1 cdt1 LOC101162468 LOC101162468 psmb3 psmb3 cdkn2c cdkn2c LOC101164480 LOC101164480 rb1 rb1 mcm8 mcm8 cdc6 cdc6 LOC111949049 LOC111949049 LOC101174910 LOC101174910 LOC101175697 LOC101175697 rps27a rps27a cdkn1c cdkn1c rpa3 rpa3 psmb7 psmb7 dyrk1a dyrk1a relch relch cdk4 cdk4 ENSORLP00000039885 ENSORLP00000039885 LOC101174707 LOC101174707 cdk7 cdk7 mnat1 mnat1 fndc3a fndc3a lin37 lin37 abl1 abl1 mcm4 mcm4 lin52 lin52 ENSORLP00000042462 ENSORLP00000042462 ppp2r3a ppp2r3a psmd3 psmd3 cables1 cables1 ENSORLP00000044710 ENSORLP00000044710 LOC101162259 LOC101162259 pola1 pola1 ENSORLP00000045038 ENSORLP00000045038 psmb8 psmb8
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
psmd13Proteasome 26S subunit, non-ATPase 13. (378 aa)
orc4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (433 aa)
H2L3G9_ORYLACyclin D3; Belongs to the cyclin family. (216 aa)
LOC101166216Cyclin-dependent kinase inhibitor 1A. (156 aa)
ccnd1Cyclin D1; Belongs to the cyclin family. (292 aa)
LOC101157953Proteasome 26S subunit, non-ATPase 4a. (372 aa)
mcm7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (727 aa)
pole3CBFD_NFYB_HMF domain-containing protein. (148 aa)
e2f1E2F transcription factor 1. (454 aa)
ppp2caSerine/threonine-protein phosphatase. (309 aa)
skp1S-phase kinase-associated protein 1; Belongs to the SKP1 family. (163 aa)
wee1Wee1-like protein kinase. (622 aa)
H2L6D0_ORYLAUncharacterized protein. (176 aa)
psma1Proteasome endopeptidase complex. (238 aa)
psmb4Proteasome subunit beta; Belongs to the peptidase T1B family. (259 aa)
LOC101174244Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
psma4Proteasome subunit alpha type. (261 aa)
LOC101168468Tyrosine-protein kinase. (1123 aa)
LOC101163574Cyclin Dx; Belongs to the cyclin family. (314 aa)
psmd8Proteasome 26S subunit, non-ATPase 8. (265 aa)
rbbp8nlRetinoblastoma binding protein 8-like. (568 aa)
cdc45CDC45 cell division cycle 45 homolog (S. cerevisiae). (569 aa)
cul1Cullin 1b; Belongs to the cullin family. (801 aa)
meiobMethionine sulfoxide reductase B1b. (462 aa)
mcm2DNA helicase; Belongs to the MCM family. (888 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (655 aa)
LOC101167568Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B. (552 aa)
LOC101172332Uncharacterized protein. (871 aa)
cdkn2dCyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4). (164 aa)
ccna1Cyclin A1; Belongs to the cyclin family. (413 aa)
psmd14Proteasome 26S subunit, non-ATPase 14. (325 aa)
cdk6Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (325 aa)
rpa1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (598 aa)
cdc7Cell division cycle 7 homolog (S. cerevisiae); Belongs to the protein kinase superfamily. (478 aa)
LOC101174851Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
psmd5Proteasome 26S subunit, non-ATPase 5. (524 aa)
psmc5Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (406 aa)
psmd9Proteasome 26S subunit, non-ATPase 9. (212 aa)
psma2Proteasome subunit alpha type. (234 aa)
psme1Proteasome activator subunit 1. (250 aa)
psmb9Proteasome subunit beta type-9; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides (By similarity). (216 aa)
psmb9-likeProteasome subunit, beta type 9-like. (217 aa)
SRCTyrosine-protein kinase. (544 aa)
ppp4r1WRNPLPNID domain-containing protein. (969 aa)
LOC101167061Protein phosphatase 2, regulatory subunit A, beta b. (589 aa)
psmd126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (961 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (1100 aa)
psmd6Proteasome 26S subunit, non-ATPase 6. (389 aa)
uba52Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
LOC101155046Proteasome subunit alpha type. (246 aa)
H2LYW2_ORYLAE2F_TDP domain-containing protein. (92 aa)
dbf4DBF4 zinc finger. (594 aa)
psmd226S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (906 aa)
LOC101173089Proteasome 26S subunit, non-ATPase 4b. (376 aa)
psmb2Proteasome subunit beta. (199 aa)
ccnhCyclin H; Belongs to the cyclin family. (386 aa)
LOC101157629Tyrosine-protein kinase. (1128 aa)
prim2DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (484 aa)
psma3Proteasome subunit alpha type. (255 aa)
psmd7Proteasome 26S subunit, non-ATPase 7. (324 aa)
mcm5DNA helicase; Belongs to the MCM family. (751 aa)
kxd1KxDL motif containing 1. (184 aa)
psmc3Proteasome 26S subunit ATPase 3; Belongs to the AAA ATPase family. (427 aa)
psmb1Proteasome subunit beta. (237 aa)
PPP2R3BProtein phosphatase 2 regulatory subunit B''beta. (581 aa)
mcm6DNA helicase; Belongs to the MCM family. (819 aa)
orc2Origin recognition complex, subunit 2. (591 aa)
mybl2V-myb avian myeloblastosis viral oncogene homolog-like 2b. (629 aa)
fndc3bFibronectin type III domain containing 3Ba. (1209 aa)
H2M970_ORYLAUbiquitin-like domain-containing protein. (129 aa)
ubcUbiquitin B. (782 aa)
LOC101157461Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (447 aa)
prim1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (426 aa)
LOC101167467Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (445 aa)
skp2S-phase kinase-associated protein 2, E3 ubiquitin protein ligase. (421 aa)
tfdp1Transcription factor. (413 aa)
gmnnUncharacterized protein. (233 aa)
pole2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (528 aa)
psme2Proteasome activator subunit 2. (241 aa)
lin9Lin-9 DREAM MuvB core complex component. (547 aa)
LOC101155451Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (482 aa)
rpa2Replication protein A2. (280 aa)
e2f2Si:ch211-160f23.5. (442 aa)
orc3Origin recognition complex, subunit 3. (719 aa)
LOC101175566Cdk5 and Abl enzyme substrate 2a; Belongs to the cyclin family. (567 aa)
ccne2Cyclin E2; Belongs to the cyclin family. (393 aa)
psmc6Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (389 aa)
mcm9Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1116 aa)
ccne1Cyclin E1; Belongs to the cyclin family. (416 aa)
e2f4E2F transcription factor 4. (390 aa)
psmc1Proteasome 26S subunit, ATPase 1b; Belongs to the AAA ATPase family. (443 aa)
orc5Origin recognition complex, subunit 5. (441 aa)
LOC101156733Wee1-like protein kinase. (569 aa)
psma5Proteasome subunit alpha type. (241 aa)
mcm3DNA helicase; Belongs to the MCM family. (817 aa)
fnbp4Formin binding protein 4. (843 aa)
LOC101159588Cdk5 and Abl enzyme substrate 2b; Belongs to the cyclin family. (533 aa)
psmc4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (417 aa)
akt1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (496 aa)
LOC101161792SCY domain-containing protein. (126 aa)
pole4Polymerase (DNA-directed), epsilon 4, accessory subunit. (124 aa)
psmf1Uncharacterized protein. (271 aa)
ppp2r3cProtein phosphatase 2, regulatory subunit B'', gamma. (448 aa)
LOC101164754E2F transcription factor 5. (354 aa)
H2MVE2_ORYLAProtein phosphatase 4, regulatory subunit 4. (726 aa)
cdc25bRhodanese domain-containing protein. (572 aa)
LOC101158678Proteasome subunit beta. (278 aa)
LOC101174330PCI domain-containing protein. (468 aa)
rbl1Retinoblastoma-like 1 (p107). (1112 aa)
ccna2Cyclin A2; Belongs to the cyclin family. (429 aa)
LOC101169671Tyrosine-protein kinase. (500 aa)
mcm10Minichromosome maintenance 10 replication initiation factor. (916 aa)
psme3Proteasome activator subunit 3. (256 aa)
LOC111948194Proteasome subunit beta. (275 aa)
ppp2cbSerine/threonine-protein phosphatase. (309 aa)
cdk2Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
LOC110014991Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (76 aa)
psmc2Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (433 aa)
orc1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (911 aa)
LOC101160207Uncharacterized protein. (317 aa)
LOC101161318Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (544 aa)
cdkn2bCyclin-dependent kinase inhibitor 2A/B (p15, inhibits CDK4). (227 aa)
lin54Lin-54 DREAM MuvB core complex component. (798 aa)
psmd12Proteasome 26S subunit, non-ATPase 12. (457 aa)
pola2DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (603 aa)
ENSORLP00000033513DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (398 aa)
cdkn1bCyclin-dependent kinase inhibitor 1Bb. (180 aa)
psmd10Proteasome 26S subunit, non-ATPase 10. (226 aa)
E2F3E2F transcription factor 3. (444 aa)
cdt1Chromatin licensing and DNA replication factor 1. (607 aa)
LOC101162468Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
psmb3Proteasome subunit beta 3. (223 aa)
cdkn2cCyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4). (168 aa)
LOC101164480Tyrosine-protein kinase. (551 aa)
rb1Retinoblastoma 1. (916 aa)
mcm8Minichromosome maintenance 8 homologous recombination repair factor; Belongs to the MCM family. (846 aa)
cdc6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (568 aa)
LOC111949049Proteasome subunit beta. (276 aa)
LOC101174910Cyclin D2, a; Belongs to the cyclin family. (299 aa)
LOC101175697Cyclin D2, b; Belongs to the cyclin family. (370 aa)
rps27aRibosomal protein S27a. (195 aa)
cdkn1cUncharacterized protein. (210 aa)
rpa3Replication protein A3. (122 aa)
psmb7Proteasome subunit beta. (286 aa)
dyrk1aDual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A, b. (742 aa)
relchRAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (1209 aa)
cdk4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (330 aa)
ENSORLP00000039885Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (107 aa)
LOC101174707Proteasome 26S subunit, non-ATPase 11b. (422 aa)
cdk7Cyclin-dependent kinase 7; Belongs to the protein kinase superfamily. (391 aa)
mnat1CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (311 aa)
fndc3aFibronectin type III domain containing 3A. (1244 aa)
lin37Lin-37 DREAM MuvB core complex component. (248 aa)
abl1Tyrosine-protein kinase. (1106 aa)
mcm4DNA helicase; Belongs to the MCM family. (835 aa)
lin52Lin-52 DREAM MuvB core complex component. (172 aa)
ENSORLP00000042462E2F_CC-MB domain-containing protein. (167 aa)
ppp2r3aProtein phosphatase 2, regulatory subunit B'', alpha. (1373 aa)
psmd3Proteasome 26S subunit, non-ATPase 3. (516 aa)
cables1Cdk5 and Abl enzyme substrate 1. (526 aa)
ENSORLP00000044710annotation not available (829 aa)
LOC101162259Proteasome endopeptidase complex. (320 aa)
pola1DNA polymerase. (1460 aa)
ENSORLP00000045038Uncharacterized protein. (178 aa)
psmb8Proteasome subunit beta. (275 aa)
Your Current Organism:
Oryzias latipes
NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka
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