32 items (Oryzias latipes) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

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protein homology

Your Input:
	frs2	Fibroblast growth factor receptor substrate 2b. (526 aa)
	fgf4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (188 aa)
	fgf3	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (245 aa)
	Fgf1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (159 aa)
	LOC101174825	Fibroblast growth factor receptor substrate 3. (608 aa)
	fgf7	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (205 aa)
	LOC101161650	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (157 aa)
	fgf16	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (217 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	LOC101168152	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	shc1	SHC (Src homology 2 domain containing) transforming protein 1. (449 aa)
	hras	HRas proto-oncogene, GTPase a. (189 aa)
	fgfr2	Fibroblast growth factor receptor. (832 aa)
	grb2	Growth factor receptor-bound protein 2b. (218 aa)
	FGF6	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (198 aa)
	fgf23	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (263 aa)
	fgf20b	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
	SHC4	SHC adaptor protein 4. (534 aa)
	ENSORLP00000027361	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (250 aa)
	LOC101154954	Zgc:55558. (189 aa)
	plcg1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1311 aa)
	LOC101162992	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (223 aa)
	kras	GTPase KRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (By similarity). Plays an important role in the regulation of cell proliferation. (189 aa)
	CSDE1	Cold shock domain containing E1, RNA-binding. (875 aa)
	fgf5	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
	fgf18	Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family. (210 aa)
	LOC101157091	PH domain-containing protein. (761 aa)
	fgf10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (250 aa)
	gab1	GRB2-associated binding protein 1. (795 aa)
	fgf8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (214 aa)
	fgf20a	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (252 aa)
	FGF6-2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CSDE1	Fgf1	ENSORLP00000034821	ENSORLP00000001852	Cold shock domain containing E1, RNA-binding.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.400
CSDE1	LOC101161650	ENSORLP00000034821	ENSORLP00000007561	Cold shock domain containing E1, RNA-binding.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.400
CSDE1	LOC101168152	ENSORLP00000034821	ENSORLP00000011212	Cold shock domain containing E1, RNA-binding.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.530
CSDE1	LOC101174825	ENSORLP00000034821	ENSORLP00000002237	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor receptor substrate 3.	0.448
CSDE1	PIK3CA	ENSORLP00000034821	ENSORLP00000011211	Cold shock domain containing E1, RNA-binding.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.530
CSDE1	SHC4	ENSORLP00000034821	ENSORLP00000027207	Cold shock domain containing E1, RNA-binding.	SHC adaptor protein 4.	0.419
CSDE1	fgf18	ENSORLP00000034821	ENSORLP00000038417	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family.	0.530
CSDE1	fgf23	ENSORLP00000034821	ENSORLP00000019815	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family.	0.421
CSDE1	fgf3	ENSORLP00000034821	ENSORLP00000000370	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.450
CSDE1	fgf4	ENSORLP00000034821	ENSORLP00000000362	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.464
CSDE1	fgf5	ENSORLP00000034821	ENSORLP00000038193	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.437
CSDE1	fgf7	ENSORLP00000034821	ENSORLP00000002929	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.443
CSDE1	fgf8	ENSORLP00000034821	ENSORLP00000042553	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.440
CSDE1	frs2	ENSORLP00000034821	ENSORLP00000044911	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor receptor substrate 2b.	0.448
CSDE1	grb2	ENSORLP00000034821	ENSORLP00000019097	Cold shock domain containing E1, RNA-binding.	Growth factor receptor-bound protein 2b.	0.691
CSDE1	shc1	ENSORLP00000034821	ENSORLP00000012223	Cold shock domain containing E1, RNA-binding.	SHC (Src homology 2 domain containing) transforming protein 1.	0.419
ENSORLP00000027361	Fgf1	ENSORLP00000027361	ENSORLP00000001852	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.473
ENSORLP00000027361	LOC101161650	ENSORLP00000027361	ENSORLP00000007561	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.476
ENSORLP00000027361	fgf18	ENSORLP00000027361	ENSORLP00000038417	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family.	0.531
ENSORLP00000027361	fgf23	ENSORLP00000027361	ENSORLP00000019815	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family.	0.600