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fgf5 fgf5 fgf16 fgf16 shc1 shc1 hras hras grb2 grb2 fgf4 fgf4 Fgf1 Fgf1 fgf23 fgf23 LOC101161650 LOC101161650 fgf20b fgf20b SHC4 SHC4 LOC101154954 LOC101154954 kras kras CSDE1 CSDE1 fgf20a fgf20a fgf8 fgf8 fgf18 fgf18
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
fgf5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
fgf16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (217 aa)
shc1SHC (Src homology 2 domain containing) transforming protein 1. (449 aa)
hrasHRas proto-oncogene, GTPase a. (189 aa)
grb2Growth factor receptor-bound protein 2b. (218 aa)
fgf4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (188 aa)
Fgf1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (159 aa)
fgf23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (263 aa)
LOC101161650Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (157 aa)
fgf20bFibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
SHC4SHC adaptor protein 4. (534 aa)
LOC101154954Zgc:55558. (189 aa)
krasGTPase KRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (By similarity). Plays an important role in the regulation of cell proliferation. (189 aa)
CSDE1Cold shock domain containing E1, RNA-binding. (875 aa)
fgf20aFibroblast growth factor; Belongs to the heparin-binding growth factors family. (252 aa)
fgf8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (214 aa)
fgf18Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family. (210 aa)
Your Current Organism:
Oryzias latipes
NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka
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