38 items (Oryzias latipes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	fgf8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (214 aa)
	fgf20a	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (252 aa)
	fgf4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (188 aa)
	fgf3	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (245 aa)
	ppp2ca	Serine/threonine-protein phosphatase. (309 aa)
	Fgf1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (159 aa)
	LOC101171145	Sprouty RTK signaling antagonist 2. (342 aa)
	LOC101161650	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (157 aa)
	SRC	Tyrosine-protein kinase. (544 aa)
	LOC101167061	Protein phosphatase 2, regulatory subunit A, beta b. (589 aa)
	cbl	Cbl proto-oncogene, E3 ubiquitin protein ligase. (946 aa)
	uba52	Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
	anos1b	Anosmin-1.2. (704 aa)
	fndc3b	Fibronectin type III domain containing 3Ba. (1209 aa)
	LOC101159747	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (389 aa)
	LOC101158476	Cbl proto-oncogene C, E3 ubiquitin protein ligase. (557 aa)
	H2M970_ORYLA	Ubiquitin-like domain-containing protein. (129 aa)
	FGF6-2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	ubc	Ubiquitin B. (782 aa)
	fgfr1	Fibroblast growth factor receptor. (833 aa)
	frs2	Fibroblast growth factor receptor substrate 2b. (526 aa)
	LOC101163758	Uncharacterized protein. (852 aa)
	grb2	Growth factor receptor-bound protein 2b. (218 aa)
	FGF6	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (198 aa)
	fgf23	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (263 aa)
	mknk1	MAPK interacting serine/threonine kinase 1; Belongs to the protein kinase superfamily. (457 aa)
	fgf20b	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
	ENSORLP00000027361	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (250 aa)
	ppp2cb	Serine/threonine-protein phosphatase. (309 aa)
	mknk2	MAPK interacting serine/threonine kinase 2b; Belongs to the protein kinase superfamily. (475 aa)
	LOC101162992	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (223 aa)
	anos1	Uncharacterized protein. (696 aa)
	LOC101164480	Tyrosine-protein kinase. (551 aa)
	rps27a	Ribosomal protein S27a. (195 aa)
	fgf5	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
	LOC101162905	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (369 aa)
	fndc3a	Fibronectin type III domain containing 3A. (1244 aa)
	fgf10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (250 aa)

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSORLP00000027361	Fgf1	ENSORLP00000027361	ENSORLP00000001852	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.473
ENSORLP00000027361	H2M970_ORYLA	ENSORLP00000027361	ENSORLP00000015051	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Ubiquitin-like domain-containing protein.	0.415
ENSORLP00000027361	LOC101161650	ENSORLP00000027361	ENSORLP00000007561	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.476
ENSORLP00000027361	anos1	ENSORLP00000027361	ENSORLP00000034498	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Uncharacterized protein.	0.438
ENSORLP00000027361	anos1b	ENSORLP00000027361	ENSORLP00000012177	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Anosmin-1.2.	0.438
ENSORLP00000027361	fgf23	ENSORLP00000027361	ENSORLP00000019815	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family.	0.600
ENSORLP00000027361	fgf3	ENSORLP00000027361	ENSORLP00000000370	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.562
ENSORLP00000027361	fgf4	ENSORLP00000027361	ENSORLP00000000362	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.573
ENSORLP00000027361	fgf8	ENSORLP00000027361	ENSORLP00000042553	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.543
ENSORLP00000027361	fgfr1	ENSORLP00000027361	ENSORLP00000017825	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor receptor.	0.571
ENSORLP00000027361	grb2	ENSORLP00000027361	ENSORLP00000019097	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Growth factor receptor-bound protein 2b.	0.499
ENSORLP00000027361	rps27a	ENSORLP00000027361	ENSORLP00000038189	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Ribosomal protein S27a.	0.554
ENSORLP00000027361	uba52	ENSORLP00000027361	ENSORLP00000010731	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Ubiquitin A-52 residue ribosomal protein fusion product 1.	0.415
ENSORLP00000027361	ubc	ENSORLP00000027361	ENSORLP00000015065	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Ubiquitin B.	0.487
FGF6	fgf23	ENSORLP00000019694	ENSORLP00000019815	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family.	0.650
FGF6	fgf3	ENSORLP00000019694	ENSORLP00000000370	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.406
FGF6	fgfr1	ENSORLP00000019694	ENSORLP00000017825	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor receptor.	0.797
FGF6	grb2	ENSORLP00000019694	ENSORLP00000019097	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Growth factor receptor-bound protein 2b.	0.445
FGF6	rps27a	ENSORLP00000019694	ENSORLP00000038189	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Ribosomal protein S27a.	0.433
FGF6	ubc	ENSORLP00000019694	ENSORLP00000015065	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Ubiquitin B.	0.411