33 items (Oryzias latipes) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	mknk1	MAPK interacting serine/threonine kinase 1; Belongs to the protein kinase superfamily. (457 aa)
	fgf23	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (263 aa)
	FGF6	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (198 aa)
	grb2	Growth factor receptor-bound protein 2b. (218 aa)
	LOC101163758	Uncharacterized protein. (852 aa)
	ubc	Ubiquitin B. (782 aa)
	H2M970_ORYLA	Ubiquitin-like domain-containing protein. (129 aa)
	LOC101159747	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (389 aa)
	fndc3b	Fibronectin type III domain containing 3Ba. (1209 aa)
	uba52	Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
	cbl	Cbl proto-oncogene, E3 ubiquitin protein ligase. (946 aa)
	LOC101167061	Protein phosphatase 2, regulatory subunit A, beta b. (589 aa)
	SRC	Tyrosine-protein kinase. (544 aa)
	fgf16	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (217 aa)
	LOC101161650	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (157 aa)
	LOC101171145	Sprouty RTK signaling antagonist 2. (342 aa)
	Fgf1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (159 aa)
	ppp2ca	Serine/threonine-protein phosphatase. (309 aa)
	fgf4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (188 aa)
	fgf19	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	LOC101158476	Cbl proto-oncogene C, E3 ubiquitin protein ligase. (557 aa)
	FGF6-2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	frs2	Fibroblast growth factor receptor substrate 2b. (526 aa)
	fgf18	Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family. (210 aa)
	rps27a	Ribosomal protein S27a. (195 aa)
	LOC101162905	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (369 aa)
	fndc3a	Fibronectin type III domain containing 3A. (1244 aa)
	fgf8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (214 aa)
	fgf20a	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (252 aa)
	LOC101164480	Tyrosine-protein kinase. (551 aa)
	mknk2	MAPK interacting serine/threonine kinase 2b; Belongs to the protein kinase superfamily. (475 aa)
	ppp2cb	Serine/threonine-protein phosphatase. (309 aa)
	fgf20b	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FGF6	fgf18	ENSORLP00000019694	ENSORLP00000038417	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family.	0.436
FGF6	fgf19	ENSORLP00000019694	ENSORLP00000000352	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.535
FGF6	fgf23	ENSORLP00000019694	ENSORLP00000019815	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family.	0.650
FGF6	grb2	ENSORLP00000019694	ENSORLP00000019097	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Growth factor receptor-bound protein 2b.	0.445
FGF6	rps27a	ENSORLP00000019694	ENSORLP00000038189	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Ribosomal protein S27a.	0.433
FGF6	ubc	ENSORLP00000019694	ENSORLP00000015065	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Ubiquitin B.	0.411
FGF6-2	fgf18	ENSORLP00000044445	ENSORLP00000038417	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family.	0.474
FGF6-2	fgf19	ENSORLP00000044445	ENSORLP00000000352	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.542
FGF6-2	fgf23	ENSORLP00000044445	ENSORLP00000019815	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family.	0.650
FGF6-2	grb2	ENSORLP00000044445	ENSORLP00000019097	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Growth factor receptor-bound protein 2b.	0.445
FGF6-2	rps27a	ENSORLP00000044445	ENSORLP00000038189	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Ribosomal protein S27a.	0.433
FGF6-2	ubc	ENSORLP00000044445	ENSORLP00000015065	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Ubiquitin B.	0.411
Fgf1	H2M970_ORYLA	ENSORLP00000001852	ENSORLP00000015051	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Ubiquitin-like domain-containing protein.	0.411
Fgf1	LOC101158476	ENSORLP00000001852	ENSORLP00000044381	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Cbl proto-oncogene C, E3 ubiquitin protein ligase.	0.703
Fgf1	LOC101163758	ENSORLP00000001852	ENSORLP00000018205	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Uncharacterized protein.	0.703
Fgf1	cbl	ENSORLP00000001852	ENSORLP00000009540	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Cbl proto-oncogene, E3 ubiquitin protein ligase.	0.662
Fgf1	fgf18	ENSORLP00000001852	ENSORLP00000038417	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family.	0.595
Fgf1	fgf19	ENSORLP00000001852	ENSORLP00000000352	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.584
Fgf1	fgf23	ENSORLP00000001852	ENSORLP00000019815	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family.	0.575
Fgf1	fgf4	ENSORLP00000001852	ENSORLP00000000362	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.570