45 items (Oryzias latipes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	rps27a	Ribosomal protein S27a. (195 aa)
	fgf18	Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family. (210 aa)
	LOC101162905	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (369 aa)
	LOC101157091	PH domain-containing protein. (761 aa)
	fndc3a	Fibronectin type III domain containing 3A. (1244 aa)
	gab1	GRB2-associated binding protein 1. (795 aa)
	fgf8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (214 aa)
	fgf20a	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (252 aa)
	LOC101158476	Cbl proto-oncogene C, E3 ubiquitin protein ligase. (557 aa)
	FGF6-2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	frs2	Fibroblast growth factor receptor substrate 2b. (526 aa)
	H2M970_ORYLA	Ubiquitin-like domain-containing protein. (129 aa)
	LOC101159747	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (389 aa)
	fndc3b	Fibronectin type III domain containing 3Ba. (1209 aa)
	hras	HRas proto-oncogene, GTPase a. (189 aa)
	cbl	Cbl proto-oncogene, E3 ubiquitin protein ligase. (946 aa)
	shc1	SHC (Src homology 2 domain containing) transforming protein 1. (449 aa)
	LOC101168152	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	LOC101167061	Protein phosphatase 2, regulatory subunit A, beta b. (589 aa)
	uba52	Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
	LOC101163758	Uncharacterized protein. (852 aa)
	grb2	Growth factor receptor-bound protein 2b. (218 aa)
	FGF6	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (198 aa)
	fgf23	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (263 aa)
	mknk1	MAPK interacting serine/threonine kinase 1; Belongs to the protein kinase superfamily. (457 aa)
	ubc	Ubiquitin B. (782 aa)
	fgf20b	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
	SHC4	SHC adaptor protein 4. (534 aa)
	ppp2cb	Serine/threonine-protein phosphatase. (309 aa)
	LOC101154954	Zgc:55558. (189 aa)
	plcg1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1311 aa)
	mknk2	MAPK interacting serine/threonine kinase 2b; Belongs to the protein kinase superfamily. (475 aa)
	kras	GTPase KRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (By similarity). Plays an important role in the regulation of cell proliferation. (189 aa)
	CSDE1	Cold shock domain containing E1, RNA-binding. (875 aa)
	LOC101164480	Tyrosine-protein kinase. (551 aa)
	fgf19	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	fgf4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (188 aa)
	ppp2ca	Serine/threonine-protein phosphatase. (309 aa)
	Fgf1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (159 aa)
	LOC101174825	Fibroblast growth factor receptor substrate 3. (608 aa)
	LOC101171145	Sprouty RTK signaling antagonist 2. (342 aa)
	LOC101161650	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (157 aa)
	fgf16	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (217 aa)
	SRC	Tyrosine-protein kinase. (544 aa)

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CSDE1	Fgf1	ENSORLP00000034821	ENSORLP00000001852	Cold shock domain containing E1, RNA-binding.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.400
CSDE1	H2M970_ORYLA	ENSORLP00000034821	ENSORLP00000015051	Cold shock domain containing E1, RNA-binding.	Ubiquitin-like domain-containing protein.	0.456
CSDE1	LOC101159747	ENSORLP00000034821	ENSORLP00000015020	Cold shock domain containing E1, RNA-binding.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.459
CSDE1	LOC101161650	ENSORLP00000034821	ENSORLP00000007561	Cold shock domain containing E1, RNA-binding.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.400
CSDE1	LOC101162905	ENSORLP00000034821	ENSORLP00000039541	Cold shock domain containing E1, RNA-binding.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.459
CSDE1	LOC101164480	ENSORLP00000034821	ENSORLP00000036233	Cold shock domain containing E1, RNA-binding.	Tyrosine-protein kinase.	0.417
CSDE1	LOC101167061	ENSORLP00000034821	ENSORLP00000009339	Cold shock domain containing E1, RNA-binding.	Protein phosphatase 2, regulatory subunit A, beta b.	0.454
CSDE1	LOC101168152	ENSORLP00000034821	ENSORLP00000011212	Cold shock domain containing E1, RNA-binding.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.530
CSDE1	LOC101174825	ENSORLP00000034821	ENSORLP00000002237	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor receptor substrate 3.	0.448
CSDE1	PIK3CA	ENSORLP00000034821	ENSORLP00000011211	Cold shock domain containing E1, RNA-binding.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.530
CSDE1	SHC4	ENSORLP00000034821	ENSORLP00000027207	Cold shock domain containing E1, RNA-binding.	SHC adaptor protein 4.	0.419
CSDE1	SRC	ENSORLP00000034821	ENSORLP00000008431	Cold shock domain containing E1, RNA-binding.	Tyrosine-protein kinase.	0.417
CSDE1	fgf18	ENSORLP00000034821	ENSORLP00000038417	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family.	0.530
CSDE1	fgf19	ENSORLP00000034821	ENSORLP00000000352	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.412
CSDE1	fgf23	ENSORLP00000034821	ENSORLP00000019815	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family.	0.421
CSDE1	fgf4	ENSORLP00000034821	ENSORLP00000000362	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.464
CSDE1	fgf8	ENSORLP00000034821	ENSORLP00000042553	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.440
CSDE1	frs2	ENSORLP00000034821	ENSORLP00000044911	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor receptor substrate 2b.	0.448
CSDE1	grb2	ENSORLP00000034821	ENSORLP00000019097	Cold shock domain containing E1, RNA-binding.	Growth factor receptor-bound protein 2b.	0.691
CSDE1	ppp2ca	ENSORLP00000034821	ENSORLP00000001162	Cold shock domain containing E1, RNA-binding.	Serine/threonine-protein phosphatase.	0.430