40 items (Oryzias latipes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	otud3	OTU deubiquitinase 3. (356 aa)
	traf6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (569 aa)
	LOC101170323	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (584 aa)
	spata5l1	Spermatogenesis associated 5-like 1. (752 aa)
	LOC101174167	Si:dkeyp-86f7.4. (361 aa)
	LOC101159569	Motor neuron and pancreas homeobox 2a. (333 aa)
	nod1	Nucleotide-binding oligomerization domain containing 1. (938 aa)
	OTUB2	OTU deubiquitinase, ubiquitin aldehyde binding 2. (236 aa)
	pten	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (437 aa)
	tp53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity); Belongs to the p53 family. (352 aa)
	vcpip1	Valosin containing protein (p97)/p47 complex interacting protein 1. (1197 aa)
	rnf13	Ring finger protein 13. (375 aa)
	otud7a	OTU deubiquitinase 7A. (952 aa)
	LOC101167225	Ring finger protein 167. (398 aa)
	ripk2	Receptor-interacting serine-threonine kinase 2. (590 aa)
	vcp	Valosin containing protein; Belongs to the AAA ATPase family. (814 aa)
	uba52	Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
	guf1	Translation factor GUF1, mitochondrial; Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner. (675 aa)
	zranb1	Zinc finger, RAN-binding domain containing 1a. (705 aa)
	kxd1	KxDL motif containing 1. (184 aa)
	cskmt	Methyltranfer_dom domain-containing protein. (248 aa)
	otub1	Ubiquitin thioesterase. (266 aa)
	H2M970_ORYLA	Ubiquitin-like domain-containing protein. (129 aa)
	ubc	Ubiquitin B. (782 aa)
	LOC101166590	Uncharacterized protein. (280 aa)
	apc2	APC regulator of WNT signaling pathway 2. (2227 aa)
	cdk1	Cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis. Component of the kinase complex that phosphorylates the repetitive C- terminus of RNA polymerase II. Catalytic component of MPF (By similarity); Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. (303 aa)
	traf3	TNF receptor-associated factor. (450 aa)
	PTEN	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (415 aa)
	ripk1	Receptor (TNFRSF)-interacting serine-threonine kinase 1, like. (675 aa)
	tnfaip3	Tumor necrosis factor, alpha-induced protein 3. (858 aa)
	apc	APC regulator of WNT signaling pathway. (2204 aa)
	tnip1	TNFAIP3 interacting protein 1. (650 aa)
	LOC101168392	Zinc finger, RAN-binding domain containing 1b. (758 aa)
	otud7b	OTU deubiquitinase 7B. (916 aa)
	otud5	OTU deubiquitinase 5a. (550 aa)
	yod1	YOD1 deubiquitinase. (300 aa)
	rps27a	Ribosomal protein S27a. (195 aa)
	otud4	OTU domain-containing protein. (1205 aa)
	esr1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (634 aa)

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
H2M970_ORYLA	LOC101167225	ENSORLP00000015051	ENSORLP00000010220	Ubiquitin-like domain-containing protein.	Ring finger protein 167.	0.489
H2M970_ORYLA	LOC101168392	ENSORLP00000015051	ENSORLP00000029485	Ubiquitin-like domain-containing protein.	Zinc finger, RAN-binding domain containing 1b.	0.660
H2M970_ORYLA	LOC101170323	ENSORLP00000015051	ENSORLP00000001368	Ubiquitin-like domain-containing protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.609
H2M970_ORYLA	OTUB2	ENSORLP00000015051	ENSORLP00000005741	Ubiquitin-like domain-containing protein.	OTU deubiquitinase, ubiquitin aldehyde binding 2.	0.714
H2M970_ORYLA	PTEN	ENSORLP00000015051	ENSORLP00000025651	Ubiquitin-like domain-containing protein.	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family.	0.460
H2M970_ORYLA	cdk1	ENSORLP00000015051	ENSORLP00000024000	Ubiquitin-like domain-containing protein.	Cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis. Component of the kinase complex that phosphorylates the repetitive C- terminus of RNA polymerase II. Catalytic component of MPF (By similarity); Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.	0.593
H2M970_ORYLA	cskmt	ENSORLP00000015051	ENSORLP00000014068	Ubiquitin-like domain-containing protein.	Methyltranfer_dom domain-containing protein.	0.668
H2M970_ORYLA	nod1	ENSORLP00000015051	ENSORLP00000004745	Ubiquitin-like domain-containing protein.	Nucleotide-binding oligomerization domain containing 1.	0.567
H2M970_ORYLA	otub1	ENSORLP00000015051	ENSORLP00000014105	Ubiquitin-like domain-containing protein.	Ubiquitin thioesterase.	0.714
H2M970_ORYLA	otud4	ENSORLP00000015051	ENSORLP00000039072	Ubiquitin-like domain-containing protein.	OTU domain-containing protein.	0.578
H2M970_ORYLA	otud5	ENSORLP00000015051	ENSORLP00000033979	Ubiquitin-like domain-containing protein.	OTU deubiquitinase 5a.	0.791
H2M970_ORYLA	otud7a	ENSORLP00000015051	ENSORLP00000009467	Ubiquitin-like domain-containing protein.	OTU deubiquitinase 7A.	0.679
H2M970_ORYLA	otud7b	ENSORLP00000015051	ENSORLP00000031699	Ubiquitin-like domain-containing protein.	OTU deubiquitinase 7B.	0.679
H2M970_ORYLA	pten	ENSORLP00000015051	ENSORLP00000007832	Ubiquitin-like domain-containing protein.	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family.	0.460
H2M970_ORYLA	ripk1	ENSORLP00000015051	ENSORLP00000026458	Ubiquitin-like domain-containing protein.	Receptor (TNFRSF)-interacting serine-threonine kinase 1, like.	0.541
H2M970_ORYLA	rnf13	ENSORLP00000015051	ENSORLP00000009239	Ubiquitin-like domain-containing protein.	Ring finger protein 13.	0.489
H2M970_ORYLA	rps27a	ENSORLP00000015051	ENSORLP00000038189	Ubiquitin-like domain-containing protein.	Ribosomal protein S27a.	0.992
H2M970_ORYLA	spata5l1	ENSORLP00000015051	ENSORLP00000003033	Ubiquitin-like domain-containing protein.	Spermatogenesis associated 5-like 1.	0.833
H2M970_ORYLA	tnfaip3	ENSORLP00000015051	ENSORLP00000026793	Ubiquitin-like domain-containing protein.	Tumor necrosis factor, alpha-induced protein 3.	0.796
H2M970_ORYLA	tp53	ENSORLP00000015051	ENSORLP00000008031	Ubiquitin-like domain-containing protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity); Belongs to the p53 family.	0.471