41 items (Oryzias latipes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	atr	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2160 aa)
	fancl	FA complementation group L. (377 aa)
	ercc4	Excision repair cross-complementation group 4. (889 aa)
	meiob	Methionine sulfoxide reductase B1b. (462 aa)
	RPA1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (655 aa)
	CENPS	Centromere protein S. (117 aa)
	faap100	Si:dkey-57h18.1. (823 aa)
	proser1	Proline and serine rich 1. (781 aa)
	rpa1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (598 aa)
	fancf	FA complementation group F. (342 aa)
	dclre1b	DNA cross-link repair 1B. (582 aa)
	ube2t	Ubiquitin-conjugating enzyme E2T (putative). (173 aa)
	uba52	Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
	usp1	Ubiquitin carboxyl-terminal hydrolase. (785 aa)
	kxd1	KxDL motif containing 1. (184 aa)
	fanci	FA complementation group I. (1284 aa)
	wdr48	WD repeat domain 48b. (677 aa)
	H2M970_ORYLA	Ubiquitin-like domain-containing protein. (129 aa)
	ubc	Ubiquitin B. (782 aa)
	rpa2	Replication protein A2. (280 aa)
	fancm	Uncharacterized protein. (1993 aa)
	eme1	Essential meiotic structure-specific endonuclease 1. (459 aa)
	ercc1	Excision repair cross-complementation group 1. (341 aa)
	dclre1a	C2H2-type domain-containing protein. (548 aa)
	poln	Polymerase (DNA directed) nu. (1278 aa)
	fancg	Uncharacterized protein. (636 aa)
	EME2	ERCC4 domain-containing protein. (443 aa)
	faap24	FA core complex associated protein 24. (209 aa)
	nutf2	Nuclear transport factor 2. (127 aa)
	fancb	FA complementation group B. (850 aa)
	fancc	FA complementation group C. (654 aa)
	fan1	Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (971 aa)
	mus81	MUS81 structure-specific endonuclease subunit. (656 aa)
	LOC101173980	Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (269 aa)
	cenpx	Uncharacterized protein. (107 aa)
	rps27a	Ribosomal protein S27a. (195 aa)
	rpa3	Replication protein A3. (122 aa)
	LOC110015983	NTF2 domain-containing protein. (165 aa)
	slx4	SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae). (1590 aa)
	LOC101172571	FA complementation group D2. (1518 aa)
	ENSORLP00000044710	annotation not available (829 aa)

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CENPS	ENSORLP00000044710	ENSORLP00000004448	ENSORLP00000044710	Centromere protein S.	annotation not available	0.443
CENPS	LOC101172571	ENSORLP00000004448	ENSORLP00000042398	Centromere protein S.	FA complementation group D2.	0.961
CENPS	LOC110015983	ENSORLP00000004448	ENSORLP00000039531	Centromere protein S.	NTF2 domain-containing protein.	0.739
CENPS	RPA1	ENSORLP00000004448	ENSORLP00000004185	Centromere protein S.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.724
CENPS	atr	ENSORLP00000004448	ENSORLP00000015251	Centromere protein S.	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	0.567
CENPS	cenpx	ENSORLP00000004448	ENSORLP00000037961	Centromere protein S.	Uncharacterized protein.	0.978
CENPS	dclre1a	ENSORLP00000004448	ENSORLP00000026487	Centromere protein S.	C2H2-type domain-containing protein.	0.479
CENPS	dclre1b	ENSORLP00000004448	ENSORLP00000007985	Centromere protein S.	DNA cross-link repair 1B.	0.419
CENPS	eme1	ENSORLP00000004448	ENSORLP00000018481	Centromere protein S.	Essential meiotic structure-specific endonuclease 1.	0.415
CENPS	ercc1	ENSORLP00000004448	ENSORLP00000020313	Centromere protein S.	Excision repair cross-complementation group 1.	0.611
CENPS	ercc4	ENSORLP00000004448	ENSORLP00000003684	Centromere protein S.	Excision repair cross-complementation group 4.	0.747
CENPS	faap100	ENSORLP00000004448	ENSORLP00000004534	Centromere protein S.	Si:dkey-57h18.1.	0.941
CENPS	faap24	ENSORLP00000004448	ENSORLP00000031997	Centromere protein S.	FA core complex associated protein 24.	0.976
CENPS	fan1	ENSORLP00000004448	ENSORLP00000034892	Centromere protein S.	Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family.	0.432
CENPS	fancb	ENSORLP00000004448	ENSORLP00000032595	Centromere protein S.	FA complementation group B.	0.964
CENPS	fancc	ENSORLP00000004448	ENSORLP00000033538	Centromere protein S.	FA complementation group C.	0.960
CENPS	fancf	ENSORLP00000004448	ENSORLP00000007230	Centromere protein S.	FA complementation group F.	0.967
CENPS	fancg	ENSORLP00000004448	ENSORLP00000028156	Centromere protein S.	Uncharacterized protein.	0.962
CENPS	fanci	ENSORLP00000004448	ENSORLP00000014605	Centromere protein S.	FA complementation group I.	0.954
CENPS	fancl	ENSORLP00000004448	ENSORLP00000002106	Centromere protein S.	FA complementation group L.	0.968