43 items (Oryzias latipes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC101158874	Ubiquitin carboxyl-terminal hydrolase. (643 aa)
	SGK1	Non-specific serine/threonine protein kinase. (653 aa)
	ARHGAP8	Rho GTPase activating protein 8. (407 aa)
	rffl	Ring finger and FYVE-like domain containing E3 ubiquitin protein ligase. (334 aa)
	LOC101163344	Ring finger protein 34b. (407 aa)
	rps27a	Ribosomal protein S27a. (195 aa)
	rnf34	Ring finger protein 34a. (394 aa)
	phf20	PHD finger protein 20, a. (1015 aa)
	LOC101172297	Uncharacterized protein. (488 aa)
	mdm4	MDM4 regulator of p53; Belongs to the MDM2/MDM4 family. (491 aa)
	LOC101162468	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	mdm2	MDM2 proto-oncogene. (498 aa)
	usp7	Ubiquitin specific peptidase 7 (herpes virus-associated); Belongs to the peptidase C19 family. (1227 aa)
	LOC101167464	Death-domain associated protein. (729 aa)
	chek2	Checkpoint kinase 2. (526 aa)
	cdk2	Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
	ENSORLP00000027929	Uncharacterized protein. (174 aa)
	ppp2cb	Serine/threonine-protein phosphatase. (309 aa)
	ENSORLP00000027619	TAN domain-containing protein. (321 aa)
	Atm	Uncharacterized protein. (147 aa)
	ccna2	Cyclin A2; Belongs to the cyclin family. (429 aa)
	cdk1	Cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis. Component of the kinase complex that phosphorylates the repetitive C- terminus of RNA polymerase II. Catalytic component of MPF (By similarity); Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. (303 aa)
	H2L4B7_ORYLA	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family. (737 aa)
	Mtor	Serine/threonine-protein kinase TOR. (1023 aa)
	ppp2ca	Serine/threonine-protein phosphatase. (309 aa)
	LOC101174244	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	mlst8	MTOR associated protein, LST8 homolog (S. cerevisiae). (326 aa)
	ccna1	Cyclin A1; Belongs to the cyclin family. (413 aa)
	LOC101174851	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	ccng1	Cyclin G1; Belongs to the cyclin family. (342 aa)
	tp53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity); Belongs to the p53 family. (352 aa)
	LOC101167061	Protein phosphatase 2, regulatory subunit A, beta b. (589 aa)
	pdpk1	3-phosphoinositide dependent protein kinase 1b. (568 aa)
	uba52	Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
	txndc11	Thioredoxin domain containing 11. (845 aa)
	kxd1	KxDL motif containing 1. (184 aa)
	H2M970_ORYLA	Ubiquitin-like domain-containing protein. (129 aa)
	ubc	Ubiquitin B. (782 aa)
	rictor	RPTOR independent companion of MTOR, complex 2 a. (1679 aa)
	mapkap1	MAPK associated protein 1. (529 aa)
	LOC101155451	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (482 aa)
	LOC101165751	Ubiquitin carboxyl-terminal hydrolase. (401 aa)
	akt1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (496 aa)

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARHGAP8	H2L4B7_ORYLA	ENSORLP00000043677	ENSORLP00000000606	Rho GTPase activating protein 8.	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family.	0.759
ARHGAP8	Mtor	ENSORLP00000043677	ENSORLP00000000608	Rho GTPase activating protein 8.	Serine/threonine-protein kinase TOR.	0.759
ARHGAP8	SGK1	ENSORLP00000043677	ENSORLP00000045655	Rho GTPase activating protein 8.	Non-specific serine/threonine protein kinase.	0.421
ARHGAP8	mapkap1	ENSORLP00000043677	ENSORLP00000016595	Rho GTPase activating protein 8.	MAPK associated protein 1.	0.832
ARHGAP8	mlst8	ENSORLP00000043677	ENSORLP00000003877	Rho GTPase activating protein 8.	MTOR associated protein, LST8 homolog (S. cerevisiae).	0.832
ARHGAP8	rictor	ENSORLP00000043677	ENSORLP00000016159	Rho GTPase activating protein 8.	RPTOR independent companion of MTOR, complex 2 a.	0.824
Atm	ENSORLP00000027619	ENSORLP00000026266	ENSORLP00000027619	Uncharacterized protein.	TAN domain-containing protein.	0.929
Atm	H2L4B7_ORYLA	ENSORLP00000026266	ENSORLP00000000606	Uncharacterized protein.	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family.	0.787
Atm	LOC101167464	ENSORLP00000026266	ENSORLP00000033835	Uncharacterized protein.	Death-domain associated protein.	0.415
Atm	Mtor	ENSORLP00000026266	ENSORLP00000000608	Uncharacterized protein.	Serine/threonine-protein kinase TOR.	0.528
Atm	ccna1	ENSORLP00000026266	ENSORLP00000004833	Uncharacterized protein.	Cyclin A1; Belongs to the cyclin family.	0.622
Atm	ccna2	ENSORLP00000026266	ENSORLP00000024918	Uncharacterized protein.	Cyclin A2; Belongs to the cyclin family.	0.622
Atm	cdk1	ENSORLP00000026266	ENSORLP00000024000	Uncharacterized protein.	Cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis. Component of the kinase complex that phosphorylates the repetitive C- terminus of RNA polymerase II. Catalytic component of MPF (By similarity); Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.	0.562
Atm	cdk2	ENSORLP00000026266	ENSORLP00000028402	Uncharacterized protein.	Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily.	0.562
Atm	chek2	ENSORLP00000026266	ENSORLP00000032936	Uncharacterized protein.	Checkpoint kinase 2.	0.993
Atm	mdm2	ENSORLP00000026266	ENSORLP00000034706	Uncharacterized protein.	MDM2 proto-oncogene.	0.847
Atm	mdm4	ENSORLP00000026266	ENSORLP00000035882	Uncharacterized protein.	MDM4 regulator of p53; Belongs to the MDM2/MDM4 family.	0.777
Atm	rps27a	ENSORLP00000026266	ENSORLP00000038189	Uncharacterized protein.	Ribosomal protein S27a.	0.596
Atm	tp53	ENSORLP00000026266	ENSORLP00000008031	Uncharacterized protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity); Belongs to the p53 family.	0.996
Atm	ubc	ENSORLP00000026266	ENSORLP00000015065	Uncharacterized protein.	Ubiquitin B.	0.633