26 items (Oryzias latipes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC101160197	E1A binding protein p300 a. (2781 aa)
	ehmt2	Euchromatic histone-lysine N-methyltransferase 2. (1187 aa)
	JMY	Junction mediating and regulatory protein, p53 cofactor. (855 aa)
	H2LEK4_ORYLA	L3MBTL histone methyl-lysine binding protein 1a. (477 aa)
	tp53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity); Belongs to the p53 family. (352 aa)
	ttc5	Tetratricopeptide repeat domain 5. (442 aa)
	uba52	Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
	Setd9	SET domain containing 9. (265 aa)
	JMY-2	Junction mediating and regulatory protein, p53 cofactor; Belongs to the globin family. (874 aa)
	kxd1	KxDL motif containing 1. (184 aa)
	LOC101159335	SET and MYND domain containing 2a. (435 aa)
	H2M970_ORYLA	Ubiquitin-like domain-containing protein. (129 aa)
	prmt5	Protein arginine N-methyltransferase 5; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA); Belongs to the class I-like SAM-binding methyltransferase superfamily. (651 aa)
	smyd2	SET and MYND domain containing 2b. (447 aa)
	Atm	Uncharacterized protein. (147 aa)
	ENSORLP00000027619	TAN domain-containing protein. (321 aa)
	LOC101172663	Lysine methyltransferase 5Ab. (341 aa)
	kmt5a	Lysine methyltransferase 5Aa. (341 aa)
	LOC101168870	E1A binding protein p300 b. (2760 aa)
	chek2	Checkpoint kinase 2. (526 aa)
	ENSORLP00000034118	ANK_REP_REGION domain-containing protein. (110 aa)
	mdm2	MDM2 proto-oncogene. (498 aa)
	ENSORLP00000035270	SET domain-containing protein. (191 aa)
	rps27a	Ribosomal protein S27a. (195 aa)
	LOC101167635	Euchromatic histone-lysine N-methyltransferase 1b. (1331 aa)
	l3mbtl3	L3MBTL histone methyl-lysine binding protein 1b. (875 aa)

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Atm	ENSORLP00000027619	ENSORLP00000026266	ENSORLP00000027619	Uncharacterized protein.	TAN domain-containing protein.	0.929
Atm	chek2	ENSORLP00000026266	ENSORLP00000032936	Uncharacterized protein.	Checkpoint kinase 2.	0.993
Atm	mdm2	ENSORLP00000026266	ENSORLP00000034706	Uncharacterized protein.	MDM2 proto-oncogene.	0.847
Atm	rps27a	ENSORLP00000026266	ENSORLP00000038189	Uncharacterized protein.	Ribosomal protein S27a.	0.596
Atm	tp53	ENSORLP00000026266	ENSORLP00000008031	Uncharacterized protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity); Belongs to the p53 family.	0.996
Atm	ttc5	ENSORLP00000026266	ENSORLP00000009054	Uncharacterized protein.	Tetratricopeptide repeat domain 5.	0.625
ENSORLP00000027619	Atm	ENSORLP00000027619	ENSORLP00000026266	TAN domain-containing protein.	Uncharacterized protein.	0.929
ENSORLP00000027619	chek2	ENSORLP00000027619	ENSORLP00000032936	TAN domain-containing protein.	Checkpoint kinase 2.	0.938
ENSORLP00000027619	mdm2	ENSORLP00000027619	ENSORLP00000034706	TAN domain-containing protein.	MDM2 proto-oncogene.	0.847
ENSORLP00000027619	rps27a	ENSORLP00000027619	ENSORLP00000038189	TAN domain-containing protein.	Ribosomal protein S27a.	0.596
ENSORLP00000027619	tp53	ENSORLP00000027619	ENSORLP00000008031	TAN domain-containing protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity); Belongs to the p53 family.	0.956
ENSORLP00000027619	ttc5	ENSORLP00000027619	ENSORLP00000009054	TAN domain-containing protein.	Tetratricopeptide repeat domain 5.	0.625
ENSORLP00000034118	H2M970_ORYLA	ENSORLP00000034118	ENSORLP00000015051	ANK_REP_REGION domain-containing protein.	Ubiquitin-like domain-containing protein.	0.571
ENSORLP00000034118	rps27a	ENSORLP00000034118	ENSORLP00000038189	ANK_REP_REGION domain-containing protein.	Ribosomal protein S27a.	0.610
ENSORLP00000034118	tp53	ENSORLP00000034118	ENSORLP00000008031	ANK_REP_REGION domain-containing protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity); Belongs to the p53 family.	0.658
ENSORLP00000034118	uba52	ENSORLP00000034118	ENSORLP00000010731	ANK_REP_REGION domain-containing protein.	Ubiquitin A-52 residue ribosomal protein fusion product 1.	0.571
ENSORLP00000035270	tp53	ENSORLP00000035270	ENSORLP00000008031	SET domain-containing protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity); Belongs to the p53 family.	0.682
H2LEK4_ORYLA	tp53	ENSORLP00000004378	ENSORLP00000008031	L3MBTL histone methyl-lysine binding protein 1a.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity); Belongs to the p53 family.	0.727
H2M970_ORYLA	ENSORLP00000034118	ENSORLP00000015051	ENSORLP00000034118	Ubiquitin-like domain-containing protein.	ANK_REP_REGION domain-containing protein.	0.571
H2M970_ORYLA	LOC101167635	ENSORLP00000015051	ENSORLP00000040506	Ubiquitin-like domain-containing protein.	Euchromatic histone-lysine N-methyltransferase 1b.	0.571