63 items (Oryzias latipes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	H2L3G9_ORYLA	Cyclin D3; Belongs to the cyclin family. (216 aa)
	LOC101166216	Cyclin-dependent kinase inhibitor 1A. (156 aa)
	ccnd1	Cyclin D1; Belongs to the cyclin family. (292 aa)
	e2f1	E2F transcription factor 1. (454 aa)
	ppp2ca	Serine/threonine-protein phosphatase. (309 aa)
	skp1	S-phase kinase-associated protein 1; Belongs to the SKP1 family. (163 aa)
	H2L6D0_ORYLA	Uncharacterized protein. (176 aa)
	LOC101168468	Tyrosine-protein kinase. (1123 aa)
	LOC101163574	Cyclin Dx; Belongs to the cyclin family. (314 aa)
	cul1	Cullin 1b; Belongs to the cullin family. (801 aa)
	cdkn2d	Cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4). (164 aa)
	cdk6	Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (325 aa)
	SRC	Tyrosine-protein kinase. (544 aa)
	ppp4r1	WRNPLPNID domain-containing protein. (969 aa)
	LOC101167061	Protein phosphatase 2, regulatory subunit A, beta b. (589 aa)
	uba52	Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
	H2LYW2_ORYLA	E2F_TDP domain-containing protein. (92 aa)
	ccnh	Cyclin H; Belongs to the cyclin family. (386 aa)
	LOC101157629	Tyrosine-protein kinase. (1128 aa)
	kxd1	KxDL motif containing 1. (184 aa)
	PPP2R3B	Protein phosphatase 2 regulatory subunit B''beta. (581 aa)
	fndc3b	Fibronectin type III domain containing 3Ba. (1209 aa)
	H2M970_ORYLA	Ubiquitin-like domain-containing protein. (129 aa)
	ubc	Ubiquitin B. (782 aa)
	LOC101157461	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (447 aa)
	LOC101167467	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (445 aa)
	skp2	S-phase kinase-associated protein 2, E3 ubiquitin protein ligase. (421 aa)
	tfdp1	Transcription factor. (413 aa)
	e2f2	Si:ch211-160f23.5. (442 aa)
	ccne2	Cyclin E2; Belongs to the cyclin family. (393 aa)
	ccne1	Cyclin E1; Belongs to the cyclin family. (416 aa)
	e2f4	E2F transcription factor 4. (390 aa)
	fnbp4	Formin binding protein 4. (843 aa)
	ppp2r3c	Protein phosphatase 2, regulatory subunit B'', gamma. (448 aa)
	LOC101164754	E2F transcription factor 5. (354 aa)
	H2MVE2_ORYLA	Protein phosphatase 4, regulatory subunit 4. (726 aa)
	rbl1	Retinoblastoma-like 1 (p107). (1112 aa)
	LOC101169671	Tyrosine-protein kinase. (500 aa)
	ppp2cb	Serine/threonine-protein phosphatase. (309 aa)
	cdk2	Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
	LOC110014991	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (76 aa)
	LOC101160207	Uncharacterized protein. (317 aa)
	LOC101161318	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (544 aa)
	cdkn2b	Cyclin-dependent kinase inhibitor 2A/B (p15, inhibits CDK4). (227 aa)
	cdkn1b	Cyclin-dependent kinase inhibitor 1Bb. (180 aa)
	E2F3	E2F transcription factor 3. (444 aa)
	cdkn2c	Cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4). (168 aa)
	LOC101164480	Tyrosine-protein kinase. (551 aa)
	rb1	Retinoblastoma 1. (916 aa)
	LOC101174910	Cyclin D2, a; Belongs to the cyclin family. (299 aa)
	LOC101175697	Cyclin D2, b; Belongs to the cyclin family. (370 aa)
	rps27a	Ribosomal protein S27a. (195 aa)
	cdkn1c	Uncharacterized protein. (210 aa)
	relch	RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (1209 aa)
	cdk4	Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (330 aa)
	ENSORLP00000039885	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (107 aa)
	cdk7	Cyclin-dependent kinase 7; Belongs to the protein kinase superfamily. (391 aa)
	mnat1	CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (311 aa)
	fndc3a	Fibronectin type III domain containing 3A. (1244 aa)
	abl1	Tyrosine-protein kinase. (1106 aa)
	ENSORLP00000042462	E2F_CC-MB domain-containing protein. (167 aa)
	ppp2r3a	Protein phosphatase 2, regulatory subunit B'', alpha. (1373 aa)
	ENSORLP00000045038	Uncharacterized protein. (178 aa)

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
E2F3	ENSORLP00000039885	ENSORLP00000034471	ENSORLP00000039885	E2F transcription factor 3.	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.	0.414
E2F3	ENSORLP00000045038	ENSORLP00000034471	ENSORLP00000045038	E2F transcription factor 3.	Uncharacterized protein.	0.448
E2F3	H2L6D0_ORYLA	ENSORLP00000034471	ENSORLP00000001376	E2F transcription factor 3.	Uncharacterized protein.	0.448
E2F3	LOC101160207	ENSORLP00000034471	ENSORLP00000031020	E2F transcription factor 3.	Uncharacterized protein.	0.448
E2F3	LOC101164754	ENSORLP00000034471	ENSORLP00000022426	E2F transcription factor 3.	E2F transcription factor 5.	0.682
E2F3	LOC101166216	ENSORLP00000034471	ENSORLP00000000343	E2F transcription factor 3.	Cyclin-dependent kinase inhibitor 1A.	0.448
E2F3	LOC101174910	ENSORLP00000034471	ENSORLP00000037950	E2F transcription factor 3.	Cyclin D2, a; Belongs to the cyclin family.	0.551
E2F3	LOC101175697	ENSORLP00000034471	ENSORLP00000038129	E2F transcription factor 3.	Cyclin D2, b; Belongs to the cyclin family.	0.551
E2F3	LOC110014991	ENSORLP00000034471	ENSORLP00000028444	E2F transcription factor 3.	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.	0.414
E2F3	ccnd1	ENSORLP00000034471	ENSORLP00000000387	E2F transcription factor 3.	Cyclin D1; Belongs to the cyclin family.	0.551
E2F3	ccne1	ENSORLP00000034471	ENSORLP00000019428	E2F transcription factor 3.	Cyclin E1; Belongs to the cyclin family.	0.738
E2F3	ccne2	ENSORLP00000034471	ENSORLP00000019207	E2F transcription factor 3.	Cyclin E2; Belongs to the cyclin family.	0.738
E2F3	cdk2	ENSORLP00000034471	ENSORLP00000028402	E2F transcription factor 3.	Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily.	0.946
E2F3	cdk4	ENSORLP00000034471	ENSORLP00000039035	E2F transcription factor 3.	Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily.	0.482
E2F3	cdk6	ENSORLP00000034471	ENSORLP00000005122	E2F transcription factor 3.	Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily.	0.502
E2F3	cdkn1b	ENSORLP00000034471	ENSORLP00000033899	E2F transcription factor 3.	Cyclin-dependent kinase inhibitor 1Bb.	0.448
E2F3	cdkn1c	ENSORLP00000034471	ENSORLP00000038321	E2F transcription factor 3.	Uncharacterized protein.	0.448
E2F3	cul1	ENSORLP00000034471	ENSORLP00000003749	E2F transcription factor 3.	Cullin 1b; Belongs to the cullin family.	0.406
E2F3	e2f1	ENSORLP00000034471	ENSORLP00000001148	E2F transcription factor 3.	E2F transcription factor 1.	0.964
E2F3	e2f2	ENSORLP00000034471	ENSORLP00000017999	E2F transcription factor 3.	Si:ch211-160f23.5.	0.909