STRINGSTRING
psmb8 psmb8 psmd13 psmd13 orc4 orc4 LOC101157953 LOC101157953 anapc4 anapc4 mcm7 mcm7 pole3 pole3 skp1 skp1 anapc2 anapc2 psma1 psma1 psmb4 psmb4 psma4 psma4 bicra bicra psmd8 psmd8 pold3 pold3 lig1 lig1 gins1 gins1 anapc10 anapc10 cul1 cul1 meiob meiob mcm2 mcm2 RPA1 RPA1 rfc3 rfc3 ccna1 ccna1 psmd14 psmd14 anapc1 anapc1 LOC101157486 LOC101157486 rpa1 rpa1 psmd5 psmd5 psmc5 psmc5 LOC101165789 LOC101165789 psmd9 psmd9 psma2 psma2 psme1 psme1 psmb9 psmb9 psmb9-like psmb9-like psmd1 psmd1 POLE POLE LOC101154878 LOC101154878 psmd6 psmd6 uba52 uba52 LOC101155046 LOC101155046 anapc16 anapc16 ube2c ube2c gins2 gins2 LOC101173089 LOC101173089 tm7sf3 tm7sf3 psmb2 psmb2 H2M2L4_ORYLA H2M2L4_ORYLA prim2 prim2 LOC101166554 LOC101166554 LOC101174862 LOC101174862 psma3 psma3 psmd7 psmd7 dna2 dna2 mcm5 mcm5 kxd1 kxd1 psmc3 psmc3 psmb1 psmb1 cdc16 cdc16 mcm6 mcm6 pold1 pold1 ube2s ube2s orc2 orc2 gins4 gins4 RCBTB1 RCBTB1 H2M970_ORYLA H2M970_ORYLA ubc ubc gins3 gins3 prim1 prim1 skp2 skp2 pold2 pold2 gmnn gmnn pole2 pole2 psme2 psme2 H2MG95_ORYLA H2MG95_ORYLA rpa2 rpa2 anapc5 anapc5 orc3 orc3 ccne2 ccne2 FZR1 FZR1 psmc6 psmc6 mcm9 mcm9 ccne1 ccne1 psmc1 psmc1 orc5 orc5 anapc7 anapc7 psma5 psma5 mcm3 mcm3 LOC101156678 LOC101156678 LOC110016721 LOC110016721 psmc4 psmc4 LOC101161792 LOC101161792 pole4 pole4 psmf1 psmf1 LOC101158678 LOC101158678 rfc2 rfc2 LOC101174330 LOC101174330 ccna2 ccna2 rfc4 rfc4 cdc23 cdc23 psme3 psme3 LOC111948194 LOC111948194 rcbtb2 rcbtb2 cdk2 cdk2 ENSORLP00000028480 ENSORLP00000028480 pold4 pold4 psmc2 psmc2 orc1 orc1 anapc11 anapc11 psmd12 psmd12 pola2 pola2 ENSORLP00000033333 ENSORLP00000033333 ENSORLP00000033350 ENSORLP00000033350 ENSORLP00000033513 ENSORLP00000033513 psmd10 psmd10 psma8 psma8 rfc5 rfc5 psme4 psme4 cdt1 cdt1 psmb3 psmb3 fen1 fen1 mcm8 mcm8 cdc6 cdc6 pcna pcna LOC111949049 LOC111949049 rps27a rps27a rpa3 rpa3 psmb7 psmb7 LOC101172133 LOC101172133 ENSORLP00000038704 ENSORLP00000038704 fam89a fam89a LOC101174707 LOC101174707 mcm4 mcm4 bicral bicral anapc15 anapc15 psmd3 psmd3 rfc1 rfc1 ENSORLP00000044710 ENSORLP00000044710 LOC101162259 LOC101162259 pola1 pola1 Cdc27 Cdc27
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
psmb8Proteasome subunit beta. (275 aa)
psmd13Proteasome 26S subunit, non-ATPase 13. (378 aa)
orc4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (433 aa)
LOC101157953Proteasome 26S subunit, non-ATPase 4a. (372 aa)
anapc4Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. (805 aa)
mcm7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (727 aa)
pole3CBFD_NFYB_HMF domain-containing protein. (148 aa)
skp1S-phase kinase-associated protein 1; Belongs to the SKP1 family. (163 aa)
anapc2Anaphase promoting complex subunit 2; Belongs to the cullin family. (802 aa)
psma1Proteasome endopeptidase complex. (238 aa)
psmb4Proteasome subunit beta; Belongs to the peptidase T1B family. (259 aa)
psma4Proteasome subunit alpha type. (261 aa)
bicraBRD4 interacting chromatin remodeling complex associated protein. (1712 aa)
psmd8Proteasome 26S subunit, non-ATPase 8. (265 aa)
pold3Polymerase (DNA-directed), delta 3, accessory subunit. (441 aa)
lig1DNA ligase. (993 aa)
gins1GINS complex subunit 1 (Psf1 homolog). (196 aa)
anapc10Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (186 aa)
cul1Cullin 1b; Belongs to the cullin family. (801 aa)
meiobMethionine sulfoxide reductase B1b. (462 aa)
mcm2DNA helicase; Belongs to the MCM family. (888 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (655 aa)
rfc3Replication factor C (activator 1) 3. (356 aa)
ccna1Cyclin A1; Belongs to the cyclin family. (413 aa)
psmd14Proteasome 26S subunit, non-ATPase 14. (325 aa)
anapc1Anaphase promoting complex subunit 1. (1673 aa)
LOC101157486Zgc:110269. (329 aa)
rpa1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (598 aa)
psmd5Proteasome 26S subunit, non-ATPase 5. (524 aa)
psmc5Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (406 aa)
LOC101165789Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1. (589 aa)
psmd9Proteasome 26S subunit, non-ATPase 9. (212 aa)
psma2Proteasome subunit alpha type. (234 aa)
psme1Proteasome activator subunit 1. (250 aa)
psmb9Proteasome subunit beta type-9; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides (By similarity). (216 aa)
psmb9-likeProteasome subunit, beta type 9-like. (217 aa)
psmd126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (961 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (1100 aa)
LOC101154878Ubiquitin-conjugating enzyme E2E 1; Belongs to the ubiquitin-conjugating enzyme family. (191 aa)
psmd6Proteasome 26S subunit, non-ATPase 6. (389 aa)
uba52Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
LOC101155046Proteasome subunit alpha type. (246 aa)
anapc16Anaphase promoting complex subunit 16. (83 aa)
ube2cUbiquitin-conjugating enzyme E2C; Belongs to the ubiquitin-conjugating enzyme family. (184 aa)
gins2DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (186 aa)
LOC101173089Proteasome 26S subunit, non-ATPase 4b. (376 aa)
tm7sf3Transmembrane 7 superfamily member 3. (565 aa)
psmb2Proteasome subunit beta. (199 aa)
H2M2L4_ORYLABLM10_mid domain-containing protein. (567 aa)
prim2DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (484 aa)
LOC101166554ATPase family AAA domain containing 5a. (1758 aa)
LOC101174862Fizzy/cell division cycle 20 related 1b. (492 aa)
psma3Proteasome subunit alpha type. (255 aa)
psmd7Proteasome 26S subunit, non-ATPase 7. (324 aa)
dna2DNA replication helicase/nuclease 2. (1396 aa)
mcm5DNA helicase; Belongs to the MCM family. (751 aa)
kxd1KxDL motif containing 1. (184 aa)
psmc3Proteasome 26S subunit ATPase 3; Belongs to the AAA ATPase family. (427 aa)
psmb1Proteasome subunit beta. (237 aa)
cdc16Cell division cycle 16 homolog (S. cerevisiae). (618 aa)
mcm6DNA helicase; Belongs to the MCM family. (819 aa)
pold1DNA polymerase. (1107 aa)
ube2sUbiquitin-conjugating enzyme E2S; Belongs to the ubiquitin-conjugating enzyme family. (226 aa)
orc2Origin recognition complex, subunit 2. (591 aa)
gins4DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (224 aa)
RCBTB1RCC1 and BTB domain containing protein 1. (531 aa)
H2M970_ORYLAUbiquitin-like domain-containing protein. (129 aa)
ubcUbiquitin B. (782 aa)
gins3GINS complex subunit 3. (211 aa)
prim1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (426 aa)
skp2S-phase kinase-associated protein 2, E3 ubiquitin protein ligase. (421 aa)
pold2Polymerase (DNA directed), delta 2, regulatory subunit. (524 aa)
gmnnUncharacterized protein. (233 aa)
pole2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (528 aa)
psme2Proteasome activator subunit 2. (241 aa)
H2MG95_ORYLARing-box 1, E3 ubiquitin protein ligase. (82 aa)
rpa2Replication protein A2. (280 aa)
anapc5Anaphase promoting complex subunit 5. (773 aa)
orc3Origin recognition complex, subunit 3. (719 aa)
ccne2Cyclin E2; Belongs to the cyclin family. (393 aa)
FZR1Fizzy/cell division cycle 20 related 1a. (498 aa)
psmc6Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (389 aa)
mcm9Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1116 aa)
ccne1Cyclin E1; Belongs to the cyclin family. (416 aa)
psmc1Proteasome 26S subunit, ATPase 1b; Belongs to the AAA ATPase family. (443 aa)
orc5Origin recognition complex, subunit 5. (441 aa)
anapc7Anaphase promoting complex subunit 7. (565 aa)
psma5Proteasome subunit alpha type. (241 aa)
mcm3DNA helicase; Belongs to the MCM family. (817 aa)
LOC101156678UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (194 aa)
LOC110016721Ubiquitin-conjugating enzyme E2E 2; Belongs to the ubiquitin-conjugating enzyme family. (201 aa)
psmc4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (417 aa)
LOC101161792SCY domain-containing protein. (126 aa)
pole4Polymerase (DNA-directed), epsilon 4, accessory subunit. (124 aa)
psmf1Uncharacterized protein. (271 aa)
LOC101158678Proteasome subunit beta. (278 aa)
rfc2Replication factor C (activator 1) 2. (355 aa)
LOC101174330PCI domain-containing protein. (468 aa)
ccna2Cyclin A2; Belongs to the cyclin family. (429 aa)
rfc4Replication factor C (activator 1) 4. (355 aa)
cdc23CDC23 (cell division cycle 23, yeast, homolog). (559 aa)
psme3Proteasome activator subunit 3. (256 aa)
LOC111948194Proteasome subunit beta. (275 aa)
rcbtb2Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. (527 aa)
cdk2Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
ENSORLP00000028480Uncharacterized protein. (144 aa)
pold4Si:dkey-28b4.7. (108 aa)
psmc2Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (433 aa)
orc1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (911 aa)
anapc11APC11 anaphase promoting complex subunit 11 homolog (yeast). (84 aa)
psmd12Proteasome 26S subunit, non-ATPase 12. (457 aa)
pola2DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (603 aa)
ENSORLP00000033333Proteasome subunit beta. (293 aa)
ENSORLP00000033350Uncharacterized protein. (150 aa)
ENSORLP00000033513DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (398 aa)
psmd10Proteasome 26S subunit, non-ATPase 10. (226 aa)
psma8Proteasome subunit alpha type. (251 aa)
rfc5Replication factor C (activator 1) 5. (335 aa)
psme4Proteasome activator subunit 4a. (1848 aa)
cdt1Chromatin licensing and DNA replication factor 1. (607 aa)
psmb3Proteasome subunit beta 3. (223 aa)
fen1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (432 aa)
mcm8Minichromosome maintenance 8 homologous recombination repair factor; Belongs to the MCM family. (846 aa)
cdc6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (568 aa)
pcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (298 aa)
LOC111949049Proteasome subunit beta. (276 aa)
rps27aRibosomal protein S27a. (195 aa)
rpa3Replication protein A3. (122 aa)
psmb7Proteasome subunit beta. (286 aa)
LOC101172133ATPase family AAA domain containing 5b. (959 aa)
ENSORLP00000038704DUF3437 domain-containing protein. (311 aa)
fam89aFamily with sequence similarity 89 member A. (171 aa)
LOC101174707Proteasome 26S subunit, non-ATPase 11b. (422 aa)
mcm4DNA helicase; Belongs to the MCM family. (835 aa)
bicralBRD4 interacting chromatin remodeling complex associated protein like. (787 aa)
anapc15Anaphase promoting complex subunit 15. (137 aa)
psmd3Proteasome 26S subunit, non-ATPase 3. (516 aa)
rfc1Replication factor C subunit 1. (1152 aa)
ENSORLP00000044710annotation not available (829 aa)
LOC101162259Proteasome endopeptidase complex. (320 aa)
pola1DNA polymerase. (1460 aa)
Cdc27Cell division cycle 27. (382 aa)
Your Current Organism:
Oryzias latipes
NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka
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