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PIK3CA PIK3CA fgf19 fgf19 fgf4 fgf4 fgf3 fgf3 Fgf1 Fgf1 FGF13 FGF13 LOC101158789 LOC101158789 fgf7 fgf7 gab2 gab2 kl kl klb klb LOC101174851 LOC101174851 grb10 grb10 LOC101161650 LOC101161650 fgf16 fgf16 pdpk1 pdpk1 shc1 shc1 fgfr2 fgfr2 LOC100049521 LOC100049521 LOC101155451 LOC101155451 fgfr1 fgfr1 grb2 grb2 FGF6 FGF6 H2MLW1_ORYLA H2MLW1_ORYLA fgf23 fgf23 fgfr3 fgfr3 irs2 irs2 LCT LCT LOC101168764 LOC101168764 fgf20b fgf20b SHC4 SHC4 ENSORLP00000027361 ENSORLP00000027361 lctl lctl ENSORLP00000029856 ENSORLP00000029856 LOC101162992 LOC101162992 pde3b pde3b LOC100125446 LOC100125446 pik3cb pik3cb LOC101174984 LOC101174984 LOC101172604 LOC101172604 Lct Lct fgf5 fgf5 fgf18 fgf18 LOC101157091 LOC101157091 fgf10 fgf10 gab1 gab1 fgf8 fgf8 fgf20a fgf20a LOC101166254 LOC101166254 LOC101159420 LOC101159420 FGF6-2 FGF6-2 LOC101172253 LOC101172253 frs2 frs2 LOC101174326 LOC101174326 LOC101155126 LOC101155126 LOC101168152 LOC101168152
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
fgf19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
fgf4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (188 aa)
fgf3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (245 aa)
Fgf1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (159 aa)
FGF13Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
LOC101158789Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (251 aa)
fgf7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (205 aa)
gab2GRB2-associated binding protein 2. (674 aa)
klKlotho. (975 aa)
klbKlotho beta. (1045 aa)
LOC101174851Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
grb10Growth factor receptor-bound protein 10b. (577 aa)
LOC101161650Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (157 aa)
fgf16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (217 aa)
pdpk13-phosphoinositide dependent protein kinase 1b. (568 aa)
shc1SHC (Src homology 2 domain containing) transforming protein 1. (449 aa)
fgfr2Fibroblast growth factor receptor. (832 aa)
LOC100049521Fibroblast growth factor receptor 4. (1075 aa)
LOC101155451Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (482 aa)
fgfr1Fibroblast growth factor receptor. (833 aa)
grb2Growth factor receptor-bound protein 2b. (218 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (198 aa)
H2MLW1_ORYLAUncharacterized protein. (125 aa)
fgf23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (263 aa)
fgfr3Fibroblast growth factor receptor. (820 aa)
irs2Insulin receptor substrate 2b. (1081 aa)
LCTLactase. (1849 aa)
LOC101168764Tyrosine-protein kinase receptor. (1375 aa)
fgf20bFibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
SHC4SHC adaptor protein 4. (534 aa)
ENSORLP00000027361Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (250 aa)
lctlLactase-like b; Belongs to the glycosyl hydrolase 1 family. (585 aa)
ENSORLP00000029856Lactase. (1831 aa)
LOC101162992Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (223 aa)
pde3bPhosphodiesterase. (1103 aa)
LOC100125446Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (226 aa)
pik3cbPhosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1078 aa)
LOC101174984Insulin receptor substrate 2a. (1049 aa)
LOC101172604Thioesterase superfamily member 4. (246 aa)
LctLactase. (1891 aa)
fgf5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
fgf18Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family. (210 aa)
LOC101157091PH domain-containing protein. (761 aa)
fgf10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (250 aa)
gab1GRB2-associated binding protein 1. (795 aa)
fgf8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (214 aa)
fgf20aFibroblast growth factor; Belongs to the heparin-binding growth factors family. (252 aa)
LOC101166254Tyrosine-protein kinase receptor. (1387 aa)
LOC101159420Lactase-like a; Belongs to the glycosyl hydrolase 1 family. (474 aa)
FGF6-2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
LOC101172253Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
frs2Fibroblast growth factor receptor substrate 2b. (526 aa)
LOC101174326Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (233 aa)
LOC101155126Fibroblast growth factor receptor. (740 aa)
LOC101168152Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
Your Current Organism:
Oryzias latipes
NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka
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