11 items (Oryzias latipes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	hras	HRas proto-oncogene, GTPase a. (189 aa)
	shc1	SHC (Src homology 2 domain containing) transforming protein 1. (449 aa)
	hgf	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (712 aa)
	ranbp9	Uncharacterized protein. (835 aa)
	CSDE1	Cold shock domain containing E1, RNA-binding. (875 aa)
	kras	GTPase KRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (By similarity). Plays an important role in the regulation of cell proliferation. (189 aa)
	LOC101154954	Zgc:55558. (189 aa)
	SHC4	SHC adaptor protein 4. (534 aa)
	met	MET proto-oncogene, receptor tyrosine kinase. (1403 aa)
	grb2	Growth factor receptor-bound protein 2b. (218 aa)
	ranbp10	Ran binding protein 10. (688 aa)

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CSDE1	SHC4	ENSORLP00000034821	ENSORLP00000027207	Cold shock domain containing E1, RNA-binding.	SHC adaptor protein 4.	0.419
CSDE1	grb2	ENSORLP00000034821	ENSORLP00000019097	Cold shock domain containing E1, RNA-binding.	Growth factor receptor-bound protein 2b.	0.691
CSDE1	met	ENSORLP00000034821	ENSORLP00000024532	Cold shock domain containing E1, RNA-binding.	MET proto-oncogene, receptor tyrosine kinase.	0.640
CSDE1	shc1	ENSORLP00000034821	ENSORLP00000012223	Cold shock domain containing E1, RNA-binding.	SHC (Src homology 2 domain containing) transforming protein 1.	0.419
LOC101154954	SHC4	ENSORLP00000030026	ENSORLP00000027207	Zgc:55558.	SHC adaptor protein 4.	0.419
LOC101154954	grb2	ENSORLP00000030026	ENSORLP00000019097	Zgc:55558.	Growth factor receptor-bound protein 2b.	0.691
LOC101154954	hras	ENSORLP00000030026	ENSORLP00000014318	Zgc:55558.	HRas proto-oncogene, GTPase a.	0.911
LOC101154954	kras	ENSORLP00000030026	ENSORLP00000031976	Zgc:55558.	GTPase KRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (By similarity). Plays an important role in the regulation of cell proliferation.	0.901
LOC101154954	met	ENSORLP00000030026	ENSORLP00000024532	Zgc:55558.	MET proto-oncogene, receptor tyrosine kinase.	0.653
LOC101154954	shc1	ENSORLP00000030026	ENSORLP00000012223	Zgc:55558.	SHC (Src homology 2 domain containing) transforming protein 1.	0.419
SHC4	CSDE1	ENSORLP00000027207	ENSORLP00000034821	SHC adaptor protein 4.	Cold shock domain containing E1, RNA-binding.	0.419
SHC4	LOC101154954	ENSORLP00000027207	ENSORLP00000030026	SHC adaptor protein 4.	Zgc:55558.	0.419
SHC4	grb2	ENSORLP00000027207	ENSORLP00000019097	SHC adaptor protein 4.	Growth factor receptor-bound protein 2b.	0.992
SHC4	hras	ENSORLP00000027207	ENSORLP00000014318	SHC adaptor protein 4.	HRas proto-oncogene, GTPase a.	0.419
SHC4	kras	ENSORLP00000027207	ENSORLP00000031976	SHC adaptor protein 4.	GTPase KRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (By similarity). Plays an important role in the regulation of cell proliferation.	0.419
SHC4	met	ENSORLP00000027207	ENSORLP00000024532	SHC adaptor protein 4.	MET proto-oncogene, receptor tyrosine kinase.	0.896
grb2	CSDE1	ENSORLP00000019097	ENSORLP00000034821	Growth factor receptor-bound protein 2b.	Cold shock domain containing E1, RNA-binding.	0.691
grb2	LOC101154954	ENSORLP00000019097	ENSORLP00000030026	Growth factor receptor-bound protein 2b.	Zgc:55558.	0.691
grb2	SHC4	ENSORLP00000019097	ENSORLP00000027207	Growth factor receptor-bound protein 2b.	SHC adaptor protein 4.	0.992
grb2	hgf	ENSORLP00000019097	ENSORLP00000012036	Growth factor receptor-bound protein 2b.	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	0.519