7 items (Oryzias latipes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	gab1	GRB2-associated binding protein 1. (795 aa)
	LOC101157091	PH domain-containing protein. (761 aa)
	met	MET proto-oncogene, receptor tyrosine kinase. (1403 aa)
	grb2	Growth factor receptor-bound protein 2b. (218 aa)
	hgf	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (712 aa)
	LOC101168152	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC101157091	LOC101168152	ENSORLP00000040455	ENSORLP00000011212	PH domain-containing protein.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.944
LOC101157091	PIK3CA	ENSORLP00000040455	ENSORLP00000011211	PH domain-containing protein.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.944
LOC101157091	gab1	ENSORLP00000040455	ENSORLP00000041732	PH domain-containing protein.	GRB2-associated binding protein 1.	0.900
LOC101157091	grb2	ENSORLP00000040455	ENSORLP00000019097	PH domain-containing protein.	Growth factor receptor-bound protein 2b.	0.997
LOC101157091	hgf	ENSORLP00000040455	ENSORLP00000012036	PH domain-containing protein.	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	0.533
LOC101157091	met	ENSORLP00000040455	ENSORLP00000024532	PH domain-containing protein.	MET proto-oncogene, receptor tyrosine kinase.	0.911
LOC101168152	LOC101157091	ENSORLP00000011212	ENSORLP00000040455	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	PH domain-containing protein.	0.944
LOC101168152	PIK3CA	ENSORLP00000011212	ENSORLP00000011211	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.900
LOC101168152	gab1	ENSORLP00000011212	ENSORLP00000041732	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	GRB2-associated binding protein 1.	0.944
LOC101168152	grb2	ENSORLP00000011212	ENSORLP00000019097	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	Growth factor receptor-bound protein 2b.	0.644
LOC101168152	met	ENSORLP00000011212	ENSORLP00000024532	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	MET proto-oncogene, receptor tyrosine kinase.	0.873
PIK3CA	LOC101157091	ENSORLP00000011211	ENSORLP00000040455	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	PH domain-containing protein.	0.944
PIK3CA	LOC101168152	ENSORLP00000011211	ENSORLP00000011212	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.900
PIK3CA	gab1	ENSORLP00000011211	ENSORLP00000041732	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	GRB2-associated binding protein 1.	0.944
PIK3CA	grb2	ENSORLP00000011211	ENSORLP00000019097	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	Growth factor receptor-bound protein 2b.	0.644
PIK3CA	met	ENSORLP00000011211	ENSORLP00000024532	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	MET proto-oncogene, receptor tyrosine kinase.	0.873
gab1	LOC101157091	ENSORLP00000041732	ENSORLP00000040455	GRB2-associated binding protein 1.	PH domain-containing protein.	0.900
gab1	LOC101168152	ENSORLP00000041732	ENSORLP00000011212	GRB2-associated binding protein 1.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.944
gab1	PIK3CA	ENSORLP00000041732	ENSORLP00000011211	GRB2-associated binding protein 1.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.944
gab1	grb2	ENSORLP00000041732	ENSORLP00000019097	GRB2-associated binding protein 1.	Growth factor receptor-bound protein 2b.	0.997