13 items (Oryzias latipes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	rx2	Retinal homeobox protein Rx2; Plays a critical role in eye formation by regulating the initial specification of retinal cells and/or their subsequent proliferation. (327 aa)
	fgf19	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	kpna4	Importin subunit alpha; Belongs to the importin alpha family. (520 aa)
	lhx3	Uncharacterized protein. (401 aa)
	pax6	Paired box protein Pax-6; May be a transcription factor with important functions in eye and nasal development; Belongs to the paired homeobox family. (457 aa)
	shh	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (414 aa)
	LOC101168409	Frizzled related protein. (314 aa)
	ndrg3	Ndrg family member 3a. (384 aa)
	pxdn	Peroxidasin. (1481 aa)
	NDRG3	NDRG family member 3. (383 aa)
	sfrp1	Uncharacterized protein. (306 aa)
	fgf8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (214 aa)
	cnot10	CCR4-NOT transcription complex, subunit 10. (748 aa)

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC101168409	cnot10	ENSORLP00000017284	ENSORLP00000043538	Frizzled related protein.	CCR4-NOT transcription complex, subunit 10.	0.453
LOC101168409	kpna4	ENSORLP00000017284	ENSORLP00000007831	Frizzled related protein.	Importin subunit alpha; Belongs to the importin alpha family.	0.440
NDRG3	kpna4	ENSORLP00000029943	ENSORLP00000007831	NDRG family member 3.	Importin subunit alpha; Belongs to the importin alpha family.	0.585
NDRG3	sfrp1	ENSORLP00000029943	ENSORLP00000040398	NDRG family member 3.	Uncharacterized protein.	0.438
cnot10	LOC101168409	ENSORLP00000043538	ENSORLP00000017284	CCR4-NOT transcription complex, subunit 10.	Frizzled related protein.	0.453
cnot10	kpna4	ENSORLP00000043538	ENSORLP00000007831	CCR4-NOT transcription complex, subunit 10.	Importin subunit alpha; Belongs to the importin alpha family.	0.540
fgf19	fgf8	ENSORLP00000000352	ENSORLP00000042553	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.709
fgf8	fgf19	ENSORLP00000042553	ENSORLP00000000352	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.709
fgf8	pax6	ENSORLP00000042553	ENSORLP00000012434	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Paired box protein Pax-6; May be a transcription factor with important functions in eye and nasal development; Belongs to the paired homeobox family.	0.532
fgf8	shh	ENSORLP00000042553	ENSORLP00000013115	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.800
kpna4	LOC101168409	ENSORLP00000007831	ENSORLP00000017284	Importin subunit alpha; Belongs to the importin alpha family.	Frizzled related protein.	0.440
kpna4	NDRG3	ENSORLP00000007831	ENSORLP00000029943	Importin subunit alpha; Belongs to the importin alpha family.	NDRG family member 3.	0.585
kpna4	cnot10	ENSORLP00000007831	ENSORLP00000043538	Importin subunit alpha; Belongs to the importin alpha family.	CCR4-NOT transcription complex, subunit 10.	0.540
kpna4	ndrg3	ENSORLP00000007831	ENSORLP00000017330	Importin subunit alpha; Belongs to the importin alpha family.	Ndrg family member 3a.	0.585
lhx3	pax6	ENSORLP00000008410	ENSORLP00000012434	Uncharacterized protein.	Paired box protein Pax-6; May be a transcription factor with important functions in eye and nasal development; Belongs to the paired homeobox family.	0.400
ndrg3	kpna4	ENSORLP00000017330	ENSORLP00000007831	Ndrg family member 3a.	Importin subunit alpha; Belongs to the importin alpha family.	0.585
ndrg3	sfrp1	ENSORLP00000017330	ENSORLP00000040398	Ndrg family member 3a.	Uncharacterized protein.	0.452
pax6	fgf8	ENSORLP00000012434	ENSORLP00000042553	Paired box protein Pax-6; May be a transcription factor with important functions in eye and nasal development; Belongs to the paired homeobox family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.532
pax6	lhx3	ENSORLP00000012434	ENSORLP00000008410	Paired box protein Pax-6; May be a transcription factor with important functions in eye and nasal development; Belongs to the paired homeobox family.	Uncharacterized protein.	0.400
pax6	shh	ENSORLP00000012434	ENSORLP00000013115	Paired box protein Pax-6; May be a transcription factor with important functions in eye and nasal development; Belongs to the paired homeobox family.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.625