(13 nodes) (2010) The vertebrate makorin ubiquitin ligase gene family has been shaped by large-scale duplication and retroposition from an ancestral gonad-specific, maternal-effect gene. network (Oryzias latipes)

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Your Input:
	LOC110015347	Makorin, ring finger protein, 4. (381 aa)
	LOC101160344	Glycogen synthase kinase 3 alpha b; Belongs to the protein kinase superfamily. (480 aa)
	mkrn1	Makorin, ring finger protein, 1. (464 aa)
	tert	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. (1090 aa)
	gsk3b	Glycogen synthase kinase 3 beta, genome duplicate a. (216 aa)
	ppard	Uncharacterized protein. (517 aa)
	raf1	Raf-1 proto-oncogene, serine/threonine kinase a. (677 aa)
	mkrn2	Makorin, ring finger protein, 2. (438 aa)
	rpl7	Ribosomal protein L7. (245 aa)
	LOC101168720	Glycogen synthase kinase 3 alpha a; Belongs to the protein kinase superfamily. (438 aa)
	tp53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity); Belongs to the p53 family. (352 aa)
	pik3c3	Phosphatidylinositol 3-kinase catalytic subunit type 3. (884 aa)
	pparg	Uncharacterized protein. (549 aa)

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC101160344	mkrn2	ENSORLP00000044876	ENSORLP00000012328	Glycogen synthase kinase 3 alpha b; Belongs to the protein kinase superfamily.	Makorin, ring finger protein, 2.	0.565
LOC101160344	tp53	ENSORLP00000044876	ENSORLP00000008031	Glycogen synthase kinase 3 alpha b; Belongs to the protein kinase superfamily.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity); Belongs to the p53 family.	0.500
LOC101168720	mkrn2	ENSORLP00000008912	ENSORLP00000012328	Glycogen synthase kinase 3 alpha a; Belongs to the protein kinase superfamily.	Makorin, ring finger protein, 2.	0.565
LOC101168720	tp53	ENSORLP00000008912	ENSORLP00000008031	Glycogen synthase kinase 3 alpha a; Belongs to the protein kinase superfamily.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity); Belongs to the p53 family.	0.500
LOC110015347	gsk3b	ENSORLP00000040045	ENSORLP00000022469	Makorin, ring finger protein, 4.	Glycogen synthase kinase 3 beta, genome duplicate a.	0.416
LOC110015347	ppard	ENSORLP00000040045	ENSORLP00000030038	Makorin, ring finger protein, 4.	Uncharacterized protein.	0.572
LOC110015347	pparg	ENSORLP00000040045	ENSORLP00000036834	Makorin, ring finger protein, 4.	Uncharacterized protein.	0.559
LOC110015347	raf1	ENSORLP00000040045	ENSORLP00000014365	Makorin, ring finger protein, 4.	Raf-1 proto-oncogene, serine/threonine kinase a.	0.696
gsk3b	LOC110015347	ENSORLP00000022469	ENSORLP00000040045	Glycogen synthase kinase 3 beta, genome duplicate a.	Makorin, ring finger protein, 4.	0.416
gsk3b	mkrn1	ENSORLP00000022469	ENSORLP00000015988	Glycogen synthase kinase 3 beta, genome duplicate a.	Makorin, ring finger protein, 1.	0.418
gsk3b	mkrn2	ENSORLP00000022469	ENSORLP00000012328	Glycogen synthase kinase 3 beta, genome duplicate a.	Makorin, ring finger protein, 2.	0.586
gsk3b	tp53	ENSORLP00000022469	ENSORLP00000008031	Glycogen synthase kinase 3 beta, genome duplicate a.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity); Belongs to the p53 family.	0.500
mkrn1	gsk3b	ENSORLP00000015988	ENSORLP00000022469	Makorin, ring finger protein, 1.	Glycogen synthase kinase 3 beta, genome duplicate a.	0.418
mkrn1	raf1	ENSORLP00000015988	ENSORLP00000014365	Makorin, ring finger protein, 1.	Raf-1 proto-oncogene, serine/threonine kinase a.	0.427
mkrn1	tert	ENSORLP00000015988	ENSORLP00000017467	Makorin, ring finger protein, 1.	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.	0.594
mkrn2	LOC101160344	ENSORLP00000012328	ENSORLP00000044876	Makorin, ring finger protein, 2.	Glycogen synthase kinase 3 alpha b; Belongs to the protein kinase superfamily.	0.565
mkrn2	LOC101168720	ENSORLP00000012328	ENSORLP00000008912	Makorin, ring finger protein, 2.	Glycogen synthase kinase 3 alpha a; Belongs to the protein kinase superfamily.	0.565
mkrn2	gsk3b	ENSORLP00000012328	ENSORLP00000022469	Makorin, ring finger protein, 2.	Glycogen synthase kinase 3 beta, genome duplicate a.	0.586
mkrn2	ppard	ENSORLP00000012328	ENSORLP00000030038	Makorin, ring finger protein, 2.	Uncharacterized protein.	0.553
mkrn2	pparg	ENSORLP00000012328	ENSORLP00000036834	Makorin, ring finger protein, 2.	Uncharacterized protein.	0.548