25 items (Oryzias latipes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	gata2	Transcription factor GATA-2. (455 aa)
	LOC101174729	Aryl hydrocarbon receptor 2. (904 aa)
	ahr	Uncharacterized protein. (879 aa)
	LOC101166216	Cyclin-dependent kinase inhibitor 1A. (156 aa)
	cd34	Uncharacterized protein. (328 aa)
	LOC100049265	Caspase 3, apoptosis-related cysteine peptidase a; Belongs to the peptidase C14A family. (265 aa)
	casp3	Uncharacterized protein; Belongs to the peptidase C14A family. (290 aa)
	LOC101168921	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (410 aa)
	gusb	Beta-glucuronidase; Plays an important role in the degradation of dermatan and keratan sulfates; Belongs to the glycosyl hydrolase 2 family. (647 aa)
	LOC101172913	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
	HDAC1	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
	pxdn	Peroxidasin. (1481 aa)
	LOC101170061	Uncharacterized protein. (866 aa)
	LOC101170311	Uncharacterized protein. (723 aa)
	rplp0	60S acidic ribosomal protein P0; Ribosomal protein P0 is the functional equivalent of E.coli protein L10. (315 aa)
	LOC101167730	Glyceraldehyde-3-phosphate dehydrogenase. (335 aa)
	epo	Erythropoietin; Erythropoietin is the principal hormone involved in the regulation of erythrocyte differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Belongs to the EPO/TPO family. (185 aa)
	actb	Actin, cytoplasmic 1. (434 aa)
	ENSORLP00000034044	Interleukin; Belongs to the IL-15/IL-21 family. (168 aa)
	VAV3	Vav guanine nucleotide exchange factor 3. (864 aa)
	gapdh	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	LOC101156378	Uncharacterized protein; Belongs to the peptidase C14A family. (287 aa)
	DLK1	Delta like non-canonical Notch ligand 1. (394 aa)
	gata-1	Hematopietic transcription factor GATA-1. (417 aa)
	LOC110016899	Thrombopoietin. (177 aa)

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSORLP00000034044	LOC110016899	ENSORLP00000034044	ENSORLP00000045846	Interleukin; Belongs to the IL-15/IL-21 family.	Thrombopoietin.	0.417
HDAC1	LOC101172913	ENSORLP00000021872	ENSORLP00000017757	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.900
HDAC1	gata-1	ENSORLP00000021872	ENSORLP00000045511	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	Hematopietic transcription factor GATA-1.	0.468
HDAC1	gata2	ENSORLP00000021872	ENSORLP00000001688	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	Transcription factor GATA-2.	0.450
LOC100049265	LOC101168921	ENSORLP00000010098	ENSORLP00000011676	Caspase 3, apoptosis-related cysteine peptidase a; Belongs to the peptidase C14A family.	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	0.932
LOC100049265	casp3	ENSORLP00000010098	ENSORLP00000010793	Caspase 3, apoptosis-related cysteine peptidase a; Belongs to the peptidase C14A family.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.902
LOC100049265	pxdn	ENSORLP00000010098	ENSORLP00000022338	Caspase 3, apoptosis-related cysteine peptidase a; Belongs to the peptidase C14A family.	Peroxidasin.	0.467
LOC101156378	LOC101168921	ENSORLP00000040113	ENSORLP00000011676	Uncharacterized protein; Belongs to the peptidase C14A family.	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	0.937
LOC101156378	actb	ENSORLP00000040113	ENSORLP00000031145	Uncharacterized protein; Belongs to the peptidase C14A family.	Actin, cytoplasmic 1.	0.400
LOC101156378	pxdn	ENSORLP00000040113	ENSORLP00000022338	Uncharacterized protein; Belongs to the peptidase C14A family.	Peroxidasin.	0.485
LOC101167730	LOC101168921	ENSORLP00000028200	ENSORLP00000011676	Glyceraldehyde-3-phosphate dehydrogenase.	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	0.672
LOC101167730	actb	ENSORLP00000028200	ENSORLP00000031145	Glyceraldehyde-3-phosphate dehydrogenase.	Actin, cytoplasmic 1.	0.672
LOC101167730	gapdh	ENSORLP00000028200	ENSORLP00000038395	Glyceraldehyde-3-phosphate dehydrogenase.	Glyceraldehyde-3-phosphate dehydrogenase.	0.934
LOC101167730	pxdn	ENSORLP00000028200	ENSORLP00000022338	Glyceraldehyde-3-phosphate dehydrogenase.	Peroxidasin.	0.644
LOC101167730	rplp0	ENSORLP00000028200	ENSORLP00000026456	Glyceraldehyde-3-phosphate dehydrogenase.	60S acidic ribosomal protein P0; Ribosomal protein P0 is the functional equivalent of E.coli protein L10.	0.594
LOC101168921	LOC100049265	ENSORLP00000011676	ENSORLP00000010098	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Caspase 3, apoptosis-related cysteine peptidase a; Belongs to the peptidase C14A family.	0.932
LOC101168921	LOC101156378	ENSORLP00000011676	ENSORLP00000040113	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.937
LOC101168921	LOC101167730	ENSORLP00000011676	ENSORLP00000028200	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Glyceraldehyde-3-phosphate dehydrogenase.	0.672
LOC101168921	casp3	ENSORLP00000011676	ENSORLP00000010793	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.936
LOC101168921	gapdh	ENSORLP00000011676	ENSORLP00000038395	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Glyceraldehyde-3-phosphate dehydrogenase.	0.841