(58 nodes) (2011) Methoxychlor affects multiple hormone signaling pathways in the largemouth bass (Micropterus salmoides) liver. network (Oryzias latipes)

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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protein homology

Your Input:
	pdpk1	3-phosphoinositide dependent protein kinase 1b. (568 aa)
	snap25	Synaptosomal-associated protein; Belongs to the SNAP-25 family. (204 aa)
	esr1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (634 aa)
	mylk	Myosin, light chain kinase a. (918 aa)
	ppara	Uncharacterized protein. (480 aa)
	eno1	Enolase 1a, (alpha). (432 aa)
	abl1	Tyrosine-protein kinase. (1106 aa)
	vdac1	Voltage-dependent anion channel 1. (299 aa)
	gapdh	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	LOC101161140	Vitellogenin 3, phosvitinless. (1267 aa)
	c-fos	BZIP domain-containing protein. (376 aa)
	foxo3	Forkhead box O5. (668 aa)
	rb1	Retinoblastoma 1. (916 aa)
	LOC100125446	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (226 aa)
	pnpo	Pyridoxamine 5'-phosphate oxidase. (276 aa)
	dcxr	Dicarbonyl/L-xylulose reductase. (244 aa)
	actn1	Actinin, alpha 1. (918 aa)
	actb	Actin, cytoplasmic 1. (434 aa)
	gpx8	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (209 aa)
	PPARA	Peroxisome proliferator-activated receptor alpha b. (469 aa)
	cdc20	WD_REPEATS_REGION domain-containing protein. (501 aa)
	gpx3	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (173 aa)
	LOC101164997	Mitogen-activated protein kinase. (384 aa)
	rnf4	RING-type domain-containing protein. (194 aa)
	sirt4	NAD-dependent protein deacylase; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues; Belongs to the sirtuin family. Class II subfamily. (311 aa)
	cyp3a	Uncharacterized protein. (500 aa)
	esr2-2	Uncharacterized protein. (541 aa)
	esr2	Uncharacterized protein. (574 aa)
	HDAC1	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
	akt1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (496 aa)
	LOC101160075	DEAD (Asp-Glu-Ala-Asp) box helicase 5; Belongs to the DEAD box helicase family. (624 aa)
	ghr-2	Uncharacterized protein. (541 aa)
	GPX4	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (207 aa)
	polr2f	Polymerase (RNA) II (DNA directed) polypeptide F. (127 aa)
	LOC101172913	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
	sod2	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (226 aa)
	LOC101172340	Solute carrier family 25 member 37; Belongs to the mitochondrial carrier (TC 2.A.29) family. (311 aa)
	BAZ1A	Bromodomain adjacent to zinc finger domain 1A. (1452 aa)
	acad11	Acyl-CoA dehydrogenase family, member 11. (768 aa)
	LOC100049233	Androgen receptor beta subtype. (744 aa)
	LOC101168921	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (410 aa)
	LOC101161096	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (128 aa)
	HDAC3	Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (440 aa)
	3bhsd	3Beta_HSD domain-containing protein; Belongs to the 3-beta-HSD family. (374 aa)
	sorbs2	Sorbin and SH3 domain containing 2a. (1415 aa)
	lef1	Lymphoid enhancer-binding factor 1. (379 aa)
	LOC100302444	Nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor). (790 aa)
	gtf2b	General transcription factor IIB. (311 aa)
	pkn2	Protein kinase N2. (975 aa)
	mcm2	DNA helicase; Belongs to the MCM family. (888 aa)
	polr2g	Polymerase (RNA) II (DNA directed) polypeptide G-like. (175 aa)
	nr3c1	Glucocorticoid receptor GR1a. (793 aa)
	znf143	Zinc finger protein 143b. (625 aa)
	ube2a	Ubiquitin-conjugating enzyme E2A (RAD6 homolog); Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
	gpx1	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (184 aa)
	aurkb	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (332 aa)
	DDX5	DEAD-box helicase 5; Belongs to the DEAD box helicase family. (631 aa)
	gpx7	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (185 aa)

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
3bhsd	cyp3a	ENSORLP00000010780	ENSORLP00000024399	3Beta_HSD domain-containing protein; Belongs to the 3-beta-HSD family.	Uncharacterized protein.	0.929
3bhsd	esr1	ENSORLP00000010780	ENSORLP00000042539	3Beta_HSD domain-containing protein; Belongs to the 3-beta-HSD family.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.436
3bhsd	sod2	ENSORLP00000010780	ENSORLP00000016613	3Beta_HSD domain-containing protein; Belongs to the 3-beta-HSD family.	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family.	0.581
BAZ1A	DDX5	ENSORLP00000012999	ENSORLP00000045748	Bromodomain adjacent to zinc finger domain 1A.	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	0.586
BAZ1A	HDAC3	ENSORLP00000012999	ENSORLP00000011294	Bromodomain adjacent to zinc finger domain 1A.	Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.432
BAZ1A	LOC101160075	ENSORLP00000012999	ENSORLP00000018923	Bromodomain adjacent to zinc finger domain 1A.	DEAD (Asp-Glu-Ala-Asp) box helicase 5; Belongs to the DEAD box helicase family.	0.586
BAZ1A	LOC101172340	ENSORLP00000012999	ENSORLP00000013692	Bromodomain adjacent to zinc finger domain 1A.	Solute carrier family 25 member 37; Belongs to the mitochondrial carrier (TC 2.A.29) family.	0.438
BAZ1A	dcxr	ENSORLP00000012999	ENSORLP00000033802	Bromodomain adjacent to zinc finger domain 1A.	Dicarbonyl/L-xylulose reductase.	0.470
BAZ1A	gtf2b	ENSORLP00000012999	ENSORLP00000006167	Bromodomain adjacent to zinc finger domain 1A.	General transcription factor IIB.	0.438
BAZ1A	pkn2	ENSORLP00000012999	ENSORLP00000006142	Bromodomain adjacent to zinc finger domain 1A.	Protein kinase N2.	0.479
BAZ1A	pnpo	ENSORLP00000012999	ENSORLP00000033920	Bromodomain adjacent to zinc finger domain 1A.	Pyridoxamine 5'-phosphate oxidase.	0.435
BAZ1A	polr2f	ENSORLP00000012999	ENSORLP00000018281	Bromodomain adjacent to zinc finger domain 1A.	Polymerase (RNA) II (DNA directed) polypeptide F.	0.678
BAZ1A	polr2g	ENSORLP00000012999	ENSORLP00000003930	Bromodomain adjacent to zinc finger domain 1A.	Polymerase (RNA) II (DNA directed) polypeptide G-like.	0.508
BAZ1A	rnf4	ENSORLP00000012999	ENSORLP00000025484	Bromodomain adjacent to zinc finger domain 1A.	RING-type domain-containing protein.	0.456
BAZ1A	sirt4	ENSORLP00000012999	ENSORLP00000024755	Bromodomain adjacent to zinc finger domain 1A.	NAD-dependent protein deacylase; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues; Belongs to the sirtuin family. Class II subfamily.	0.444
BAZ1A	sorbs2	ENSORLP00000012999	ENSORLP00000010321	Bromodomain adjacent to zinc finger domain 1A.	Sorbin and SH3 domain containing 2a.	0.400
BAZ1A	znf143	ENSORLP00000012999	ENSORLP00000001395	Bromodomain adjacent to zinc finger domain 1A.	Zinc finger protein 143b.	0.420
DDX5	BAZ1A	ENSORLP00000045748	ENSORLP00000012999	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	Bromodomain adjacent to zinc finger domain 1A.	0.586
DDX5	LOC101160075	ENSORLP00000045748	ENSORLP00000018923	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	DEAD (Asp-Glu-Ala-Asp) box helicase 5; Belongs to the DEAD box helicase family.	0.901
DDX5	esr1	ENSORLP00000045748	ENSORLP00000042539	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.541