STRINGSTRING
pak1 pak1 LOC101155824 LOC101155824 H3-3B H3-3B H2L503_ORYLA H2L503_ORYLA H2L5K1_ORYLA H2L5K1_ORYLA H2L5L2_ORYLA H2L5L2_ORYLA H2L6K8_ORYLA H2L6K8_ORYLA H4C7 H4C7 H2L743_ORYLA H2L743_ORYLA LOC101159638 LOC101159638 H2LD49_ORYLA H2LD49_ORYLA sema6a sema6a cdk6 cdk6 pax5 pax5 tp53 tp53 HDAC3 HDAC3 pax6 pax6 msh6 msh6 LOC101158728 LOC101158728 H3-2 H3-2 HIST1H4J HIST1H4J H2M8G3_ORYLA H2M8G3_ORYLA meis2 meis2 sod2 sod2 thbs1 thbs1 snai2 snai2 LOC100302438 LOC100302438 H2MZJ4_ORYLA H2MZJ4_ORYLA il-17a/f-2 il-17a/f-2 ENSORLP00000043059 ENSORLP00000043059 ENSORLP00000041905 ENSORLP00000041905 il-17a/f-3 il-17a/f-3 LOC101155824-4 LOC101155824-4 LOC101155824-3 LOC101155824-3 LOC101163732 LOC101163732 LOC101155824-2 LOC101155824-2 gata5 gata5 ENSORLP00000035450 ENSORLP00000035450 dnmt1 dnmt1 MITF MITF ENSORLP00000031706 ENSORLP00000031706 drosha drosha mgmt mgmt il-17a/f-1 il-17a/f-1 spred1 spred1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
pak1Non-specific serine/threonine protein kinase. (571 aa)
LOC101155824Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
H3-3BHistone H3; Belongs to the histone H3 family. (140 aa)
H2L503_ORYLAHistone H3; Belongs to the histone H3 family. (100 aa)
H2L5K1_ORYLAHistone H3; Belongs to the histone H3 family. (136 aa)
H2L5L2_ORYLAHistone H3; Belongs to the histone H3 family. (125 aa)
H2L6K8_ORYLAHistone H3; Belongs to the histone H3 family. (107 aa)
H4C7Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (158 aa)
H2L743_ORYLAHistone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (99 aa)
LOC101159638Histone H3; Belongs to the histone H3 family. (136 aa)
H2LD49_ORYLAHistone H3; Belongs to the histone H3 family. (134 aa)
sema6aSema domain-containing protein; Belongs to the semaphorin family. (1023 aa)
cdk6Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (325 aa)
pax5Paired box 5. (396 aa)
tp53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity); Belongs to the p53 family. (352 aa)
HDAC3Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (440 aa)
pax6Paired box protein Pax-6; May be a transcription factor with important functions in eye and nasal development; Belongs to the paired homeobox family. (457 aa)
msh6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1381 aa)
LOC101158728V-rel avian reticuloendotheliosis viral oncogene homolog A. (617 aa)
H3-2Histone H3; Belongs to the histone H3 family. (139 aa)
HIST1H4JHistone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (93 aa)
H2M8G3_ORYLAHistone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (89 aa)
meis2Meis homeobox 2a. (478 aa)
sod2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (226 aa)
thbs1Uncharacterized protein. (1172 aa)
snai2Snail family zinc finger 2. (260 aa)
LOC100302438Thrombospondin 1b. (1186 aa)
H2MZJ4_ORYLAHistone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (144 aa)
il-17a/f-2Uncharacterized protein. (183 aa)
ENSORLP00000043059Histone H3; Belongs to the histone H3 family. (132 aa)
ENSORLP00000041905Histone H3; Belongs to the histone H3 family. (101 aa)
il-17a/f-3Interleukin-17A/F-3. (157 aa)
LOC101155824-4Histone H4. (103 aa)
LOC101155824-3Histone H4. (103 aa)
LOC101163732Microphthalmia-associated transcription factor 2 isoform m. (406 aa)
LOC101155824-2Histone H4. (103 aa)
gata5GATA binding protein 5. (364 aa)
ENSORLP00000035450Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (92 aa)
dnmt1DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1496 aa)
MITFMelanocyte inducing transcription factor b. (511 aa)
ENSORLP00000031706Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (96 aa)
droshaDrosha ribonuclease III. (1317 aa)
mgmtO-6-methylguanine-DNA methyltransferase. (188 aa)
il-17a/f-1Interleukin-17A/F-1. (152 aa)
spred1Sprouty related EVH1 domain containing 1. (542 aa)
Your Current Organism:
Oryzias latipes
NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka
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