31 items (Oryzias latipes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	cfl1	Cofilin 1; Belongs to the actin-binding proteins ADF family. (167 aa)
	ccnd1	Cyclin D1; Belongs to the cyclin family. (292 aa)
	LOC101169984	Receptor protein-tyrosine kinase. (1191 aa)
	axin1	Axin 1. (854 aa)
	CCK	Cholecystokinin. (138 aa)
	pten	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (437 aa)
	mmp9	Uncharacterized protein. (690 aa)
	tp53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity); Belongs to the p53 family. (352 aa)
	tlr3	Toll-like receptor 3. (917 aa)
	LOC101159441	Axin 2 (conductin, axil). (841 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	LOC101168152	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	LOC101168921	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (410 aa)
	myd88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (288 aa)
	mpc1	Mitochondrial pyruvate carrier; Mediates the uptake of pyruvate into mitochondria. Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family. (92 aa)
	LOC101163089	Aquaporin 3 (Gill blood group); Belongs to the MIP/aquaporin (TC 1.A.8) family. (299 aa)
	hras	HRas proto-oncogene, GTPase a. (189 aa)
	LOC101155451	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (482 aa)
	il10	Interleukin 10. (181 aa)
	LOX	Lysyl oxidase. (373 aa)
	egfr	Receptor protein-tyrosine kinase. (1185 aa)
	PTEN	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (415 aa)
	actb	Actin, cytoplasmic 1. (434 aa)
	kras	GTPase KRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (By similarity). Plays an important role in the regulation of cell proliferation. (189 aa)
	mdm2	MDM2 proto-oncogene. (498 aa)
	braf	B-Raf proto-oncogene, serine/threonine kinase. (823 aa)
	AXIN2	Axin 2. (791 aa)
	LOC101155494	Uncharacterized protein. (883 aa)
	vill	Villin-like. (881 aa)
	TGFBR2	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (540 aa)
	fli1	Fli-1 proto-oncogene, ETS transcription factor a. (458 aa)

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AXIN2	LOC101155494	ENSORLP00000035131	ENSORLP00000038069	Axin 2.	Uncharacterized protein.	0.668
AXIN2	LOC101159441	ENSORLP00000035131	ENSORLP00000011155	Axin 2.	Axin 2 (conductin, axil).	0.552
AXIN2	axin1	ENSORLP00000035131	ENSORLP00000006039	Axin 2.	Axin 1.	0.667
AXIN2	ccnd1	ENSORLP00000035131	ENSORLP00000000387	Axin 2.	Cyclin D1; Belongs to the cyclin family.	0.459
LOC101155451	LOC101168152	ENSORLP00000017781	ENSORLP00000011212	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.827
LOC101155451	PIK3CA	ENSORLP00000017781	ENSORLP00000011211	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.827
LOC101155451	PTEN	ENSORLP00000017781	ENSORLP00000025651	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family.	0.685
LOC101155451	kras	ENSORLP00000017781	ENSORLP00000031976	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	GTPase KRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (By similarity). Plays an important role in the regulation of cell proliferation.	0.439
LOC101155451	mdm2	ENSORLP00000017781	ENSORLP00000034706	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	MDM2 proto-oncogene.	0.972
LOC101155451	pten	ENSORLP00000017781	ENSORLP00000007832	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family.	0.685
LOC101155494	AXIN2	ENSORLP00000038069	ENSORLP00000035131	Uncharacterized protein.	Axin 2.	0.668
LOC101155494	LOC101159441	ENSORLP00000038069	ENSORLP00000011155	Uncharacterized protein.	Axin 2 (conductin, axil).	0.675
LOC101155494	axin1	ENSORLP00000038069	ENSORLP00000006039	Uncharacterized protein.	Axin 1.	0.552
LOC101155494	tp53	ENSORLP00000038069	ENSORLP00000008031	Uncharacterized protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity); Belongs to the p53 family.	0.489
LOC101159441	AXIN2	ENSORLP00000011155	ENSORLP00000035131	Axin 2 (conductin, axil).	Axin 2.	0.552
LOC101159441	LOC101155494	ENSORLP00000011155	ENSORLP00000038069	Axin 2 (conductin, axil).	Uncharacterized protein.	0.675
LOC101159441	axin1	ENSORLP00000011155	ENSORLP00000006039	Axin 2 (conductin, axil).	Axin 1.	0.676
LOC101159441	ccnd1	ENSORLP00000011155	ENSORLP00000000387	Axin 2 (conductin, axil).	Cyclin D1; Belongs to the cyclin family.	0.459
LOC101163089	vill	ENSORLP00000012759	ENSORLP00000038514	Aquaporin 3 (Gill blood group); Belongs to the MIP/aquaporin (TC 1.A.8) family.	Villin-like.	0.411
LOC101168152	LOC101155451	ENSORLP00000011212	ENSORLP00000017781	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.827