(17 nodes) (2017) Transcriptomics, metabolomics and histology indicate that high-carbohydrate diet negatively affects the liver health of blunt snout bream (Megalobrama amblycephala). network (Oryzias latipes)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC101156992	Fructose-bisphosphatase 1; Belongs to the FBPase class 1 family. (337 aa)
	LOC101162468	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	LOC101166254	Tyrosine-protein kinase receptor. (1387 aa)
	LOC101168997	Si:ch211-217a12.1. (491 aa)
	LOC101160344	Glycogen synthase kinase 3 alpha b; Belongs to the protein kinase superfamily. (480 aa)
	LOC101174244	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	pdpk1	3-phosphoinositide dependent protein kinase 1b. (568 aa)
	LOC105353973	Aminotran_1_2 domain-containing protein. (503 aa)
	rpl13a	Ribosomal protein L13a; Belongs to the universal ribosomal protein uL13 family. (228 aa)
	LOC101172281	Aminotran_1_2 domain-containing protein. (476 aa)
	LOC101161270	Glutamic pyruvate transaminase (alanine aminotransferase) 2, like. (515 aa)
	gsk3b	Glycogen synthase kinase 3 beta, genome duplicate a. (216 aa)
	LOC101168764	Tyrosine-protein kinase receptor. (1375 aa)
	LOC101161040	Fructose-1,6-bisphosphatase 1a; Belongs to the FBPase class 1 family. (291 aa)
	socs3	Suppressor of cytokine signaling 3a. (201 aa)
	LOC101168720	Glycogen synthase kinase 3 alpha a; Belongs to the protein kinase superfamily. (438 aa)
	socs3-2	Uncharacterized protein. (229 aa)

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC101156992	LOC101162468	ENSORLP00000034468	ENSORLP00000035304	Fructose-bisphosphatase 1; Belongs to the FBPase class 1 family.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.402
LOC101156992	LOC101174244	ENSORLP00000034468	ENSORLP00000001785	Fructose-bisphosphatase 1; Belongs to the FBPase class 1 family.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.402
LOC101160344	LOC101162468	ENSORLP00000044876	ENSORLP00000035304	Glycogen synthase kinase 3 alpha b; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.598
LOC101160344	LOC101174244	ENSORLP00000044876	ENSORLP00000001785	Glycogen synthase kinase 3 alpha b; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.598
LOC101160344	pdpk1	ENSORLP00000044876	ENSORLP00000009715	Glycogen synthase kinase 3 alpha b; Belongs to the protein kinase superfamily.	3-phosphoinositide dependent protein kinase 1b.	0.462
LOC101161040	LOC101162468	ENSORLP00000025768	ENSORLP00000035304	Fructose-1,6-bisphosphatase 1a; Belongs to the FBPase class 1 family.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.401
LOC101161040	LOC101174244	ENSORLP00000025768	ENSORLP00000001785	Fructose-1,6-bisphosphatase 1a; Belongs to the FBPase class 1 family.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.401
LOC101161270	LOC101168997	ENSORLP00000022170	ENSORLP00000009161	Glutamic pyruvate transaminase (alanine aminotransferase) 2, like.	Si:ch211-217a12.1.	0.901
LOC101161270	LOC101172281	ENSORLP00000022170	ENSORLP00000021620	Glutamic pyruvate transaminase (alanine aminotransferase) 2, like.	Aminotran_1_2 domain-containing protein.	0.903
LOC101161270	LOC105353973	ENSORLP00000022170	ENSORLP00000016289	Glutamic pyruvate transaminase (alanine aminotransferase) 2, like.	Aminotran_1_2 domain-containing protein.	0.904
LOC101162468	LOC101156992	ENSORLP00000035304	ENSORLP00000034468	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Fructose-bisphosphatase 1; Belongs to the FBPase class 1 family.	0.402
LOC101162468	LOC101160344	ENSORLP00000035304	ENSORLP00000044876	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Glycogen synthase kinase 3 alpha b; Belongs to the protein kinase superfamily.	0.598
LOC101162468	LOC101161040	ENSORLP00000035304	ENSORLP00000025768	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Fructose-1,6-bisphosphatase 1a; Belongs to the FBPase class 1 family.	0.401
LOC101162468	LOC101168720	ENSORLP00000035304	ENSORLP00000008912	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Glycogen synthase kinase 3 alpha a; Belongs to the protein kinase superfamily.	0.598
LOC101162468	gsk3b	ENSORLP00000035304	ENSORLP00000022469	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Glycogen synthase kinase 3 beta, genome duplicate a.	0.687
LOC101162468	pdpk1	ENSORLP00000035304	ENSORLP00000009715	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	3-phosphoinositide dependent protein kinase 1b.	0.985
LOC101166254	LOC101168764	ENSORLP00000043238	ENSORLP00000023219	Tyrosine-protein kinase receptor.	Tyrosine-protein kinase receptor.	0.546
LOC101166254	pdpk1	ENSORLP00000043238	ENSORLP00000009715	Tyrosine-protein kinase receptor.	3-phosphoinositide dependent protein kinase 1b.	0.465
LOC101166254	socs3	ENSORLP00000043238	ENSORLP00000027499	Tyrosine-protein kinase receptor.	Suppressor of cytokine signaling 3a.	0.923
LOC101168720	LOC101162468	ENSORLP00000008912	ENSORLP00000035304	Glycogen synthase kinase 3 alpha a; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.598