14 items (Oryzias latipes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC101167730	Glyceraldehyde-3-phosphate dehydrogenase. (335 aa)
	H2L4B7_ORYLA	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family. (737 aa)
	Mtor	Serine/threonine-protein kinase TOR. (1023 aa)
	nfkb2	Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100). (956 aa)
	aptx	Aprataxin. (333 aa)
	LOC101167550	Ankyrin repeat and KH domain containing 1. (2658 aa)
	rnf8	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (516 aa)
	pgk1	Phosphoglycerate kinase. (421 aa)
	tonsl	Tonsoku-like, DNA repair protein. (1427 aa)
	tnfaip3	Tumor necrosis factor, alpha-induced protein 3. (858 aa)
	mb	Myoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. (147 aa)
	nrros	Negative regulator of reactive oxygen species. (682 aa)
	hspa5	Uncharacterized protein; Belongs to the heat shock protein 70 family. (653 aa)
	emsy	EMSY transcriptional repressor, BRCA2 interacting. (1265 aa)

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
H2L4B7_ORYLA	Mtor	ENSORLP00000000606	ENSORLP00000000608	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family.	Serine/threonine-protein kinase TOR.	0.968
H2L4B7_ORYLA	rnf8	ENSORLP00000000606	ENSORLP00000015004	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family.	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]	0.496
LOC101167550	aptx	ENSORLP00000008684	ENSORLP00000007838	Ankyrin repeat and KH domain containing 1.	Aprataxin.	0.413
LOC101167550	emsy	ENSORLP00000008684	ENSORLP00000043015	Ankyrin repeat and KH domain containing 1.	EMSY transcriptional repressor, BRCA2 interacting.	0.514
LOC101167550	nrros	ENSORLP00000008684	ENSORLP00000031456	Ankyrin repeat and KH domain containing 1.	Negative regulator of reactive oxygen species.	0.593
LOC101167550	tnfaip3	ENSORLP00000008684	ENSORLP00000026793	Ankyrin repeat and KH domain containing 1.	Tumor necrosis factor, alpha-induced protein 3.	0.595
LOC101167730	hspa5	ENSORLP00000028200	ENSORLP00000036380	Glyceraldehyde-3-phosphate dehydrogenase.	Uncharacterized protein; Belongs to the heat shock protein 70 family.	0.614
LOC101167730	pgk1	ENSORLP00000028200	ENSORLP00000017634	Glyceraldehyde-3-phosphate dehydrogenase.	Phosphoglycerate kinase.	0.998
Mtor	H2L4B7_ORYLA	ENSORLP00000000608	ENSORLP00000000606	Serine/threonine-protein kinase TOR.	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family.	0.968
Mtor	rnf8	ENSORLP00000000608	ENSORLP00000015004	Serine/threonine-protein kinase TOR.	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]	0.496
aptx	LOC101167550	ENSORLP00000007838	ENSORLP00000008684	Aprataxin.	Ankyrin repeat and KH domain containing 1.	0.413
aptx	emsy	ENSORLP00000007838	ENSORLP00000043015	Aprataxin.	EMSY transcriptional repressor, BRCA2 interacting.	0.830
aptx	nrros	ENSORLP00000007838	ENSORLP00000031456	Aprataxin.	Negative regulator of reactive oxygen species.	0.455
aptx	rnf8	ENSORLP00000007838	ENSORLP00000015004	Aprataxin.	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]	0.556
aptx	tonsl	ENSORLP00000007838	ENSORLP00000018444	Aprataxin.	Tonsoku-like, DNA repair protein.	0.810
emsy	LOC101167550	ENSORLP00000043015	ENSORLP00000008684	EMSY transcriptional repressor, BRCA2 interacting.	Ankyrin repeat and KH domain containing 1.	0.514
emsy	aptx	ENSORLP00000043015	ENSORLP00000007838	EMSY transcriptional repressor, BRCA2 interacting.	Aprataxin.	0.830
emsy	nrros	ENSORLP00000043015	ENSORLP00000031456	EMSY transcriptional repressor, BRCA2 interacting.	Negative regulator of reactive oxygen species.	0.533
emsy	rnf8	ENSORLP00000043015	ENSORLP00000015004	EMSY transcriptional repressor, BRCA2 interacting.	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]	0.636
emsy	tonsl	ENSORLP00000043015	ENSORLP00000018444	EMSY transcriptional repressor, BRCA2 interacting.	Tonsoku-like, DNA repair protein.	0.850