STRINGSTRING
LOC101158436 LOC101158436 lmx1b lmx1b sox1 sox1 foxg1 foxg1 shh shh six3 six3 pax6 pax6 LOC101168921 LOC101168921 hoxc4 hoxc4 gdnf gdnf LOC101168720 LOC101168720 lamp1 lamp1 Mtor Mtor H2L4B7_ORYLA H2L4B7_ORYLA LOC101160344 LOC101160344 six3-2 six3-2 fgf8 fgf8 pitx1 pitx1 LOC101166980 LOC101166980 bdnf bdnf actb actb LOC111949309 LOC111949309 snca snca lrp5 lrp5 en1 en1 th th gsk3b gsk3b
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC101158436Transcription factor EB. (511 aa)
lmx1bLIM homeobox transcription factor 1, beta b. (462 aa)
sox1HMG box domain-containing protein. (322 aa)
foxg1Fork-head domain-containing protein. (461 aa)
shhHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (414 aa)
six3Homeobox protein SIX3; Transcriptional regulator which can act as both a transcriptional repressor and activator by binding a ATTA homeodomain core recognition sequence on these target genes. During forebrain development represses WNT1 expression allowing zona limitans intrathalamica formation and thereby ensuring proper anterio-posterior patterning of the diencephalon and formation of the rostral diencephalon. Acts as a direct upstream activator of SHH expression in the rostral diencephalon ventral midline and that in turn SHH maintains its expression. In addition, Six3 activity is re [...] (272 aa)
pax6Paired box protein Pax-6; May be a transcription factor with important functions in eye and nasal development; Belongs to the paired homeobox family. (457 aa)
LOC101168921Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (410 aa)
hoxc4Homeobox protein Hox-C4; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Antp homeobox family. Deformed subfamily. (261 aa)
gdnfGlial cell line-derived neurotrophic factor; Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high- affinity dopamine uptake. (265 aa)
LOC101168720Glycogen synthase kinase 3 alpha a; Belongs to the protein kinase superfamily. (438 aa)
lamp1Lysosomal associated membrane protein 1a. (420 aa)
MtorSerine/threonine-protein kinase TOR. (1023 aa)
H2L4B7_ORYLAMechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family. (737 aa)
LOC101160344Glycogen synthase kinase 3 alpha b; Belongs to the protein kinase superfamily. (480 aa)
six3-2Homeobox protein SIX3. (323 aa)
fgf8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (214 aa)
pitx1Homeobox protein. (316 aa)
LOC101166980Homeobox protein. (340 aa)
bdnfBrain-derived neurotrophic factor; Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it; Belongs to the NGF-beta family. (281 aa)
actbActin, cytoplasmic 1. (434 aa)
LOC111949309HMG box domain-containing protein. (338 aa)
sncaUncharacterized protein; Belongs to the synuclein family. (152 aa)
lrp5Low density lipoprotein receptor-related protein 5. (1634 aa)
en1Homeobox protein engrailed-like. (280 aa)
thTyrosine hydroxylase 1. (489 aa)
gsk3bGlycogen synthase kinase 3 beta, genome duplicate a. (216 aa)
Your Current Organism:
Oryzias latipes
NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka
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