(45 nodes) (2018) ROS signaling and ER stress in cardiovascular disease. network (Oryzias latipes)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	calm3	Calmodulin-A; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. (149 aa)
	tp53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity); Belongs to the p53 family. (352 aa)
	keap1	Kelch-like ECH-associated protein 1b. (621 aa)
	rasgrf2	Ras protein-specific guanine nucleotide-releasing factor 2b. (1269 aa)
	LOC101160304	Calreticulin. (415 aa)
	LOC101174903	Amino acid transporter. (506 aa)
	calml4	Calmodulin-like 4a. (153 aa)
	LOC101167791	Amino acid transporter. (663 aa)
	LOC101160301	Amino acid transporter. (527 aa)
	Mtor	Serine/threonine-protein kinase TOR. (1023 aa)
	egf	Epidermal growth factor. (966 aa)
	LOC101157922	Rhodopsin. (366 aa)
	atg7	ATG7 autophagy related 7 homolog (S. cerevisiae). (716 aa)
	kfh-g	Green-sensitive opsin; Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal; Belongs to the G-protein coupled receptor 1 family. Opsin subfamily. (351 aa)
	vdac1	Voltage-dependent anion channel 1. (299 aa)
	LOC101170557	Amino acid transporter. (553 aa)
	atf4	BZIP domain-containing protein. (438 aa)
	LOC101158336	Rhodopsin. (367 aa)
	RASGRF1	Ras protein specific guanine nucleotide releasing factor 1. (1252 aa)
	nox1	NADPH oxidase 1. (577 aa)
	LOC101166254	Tyrosine-protein kinase receptor. (1387 aa)
	H2L4B7_ORYLA	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family. (737 aa)
	LOC100049419	Calmodulin. (149 aa)
	kras	GTPase KRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (By similarity). Plays an important role in the regulation of cell proliferation. (189 aa)
	LOC101159662	Amino acid transporter. (527 aa)
	xbp1	X-box binding protein 1. (259 aa)
	slc1a4	Amino acid transporter. (537 aa)
	LOC101168764	Tyrosine-protein kinase receptor. (1375 aa)
	LOC101169735	Calreticulin. (412 aa)
	LOC100049422	Uncharacterized protein; Belongs to the calmodulin family. (163 aa)
	egfr	Receptor protein-tyrosine kinase. (1185 aa)
	LOC101162115	Calreticulin. (373 aa)
	atf6	BZIP domain-containing protein. (645 aa)
	cd36	CD36 molecule (thrombospondin receptor); Belongs to the CD36 family. (466 aa)
	atg5	Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
	LOC101172725	Amino acid transporter. (578 aa)
	SLC1A3	Amino acid transporter. (526 aa)
	slc1a2	Amino acid transporter. (526 aa)
	slc1a1	Amino acid transporter. (489 aa)
	Mcu	Mitochondrial calcium uniporter. (331 aa)
	nox4	FAD-binding FR-type domain-containing protein. (556 aa)
	RHO	Rhodopsin. (352 aa)
	rho	Rhodopsin; Photoreceptor required for image-forming vision at low light intensity. While most salt water fish species use retinal as chromophore, most freshwater fish use 3-dehydroretinal, or a mixture of retinal and 3-dehydroretinal. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G-proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by arrestin and terminates signaling (By similarity). (354 aa)
	LOC111949093	Amino acid transporter. (579 aa)
	txn	Thioredoxin; Belongs to the thioredoxin family. (106 aa)

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
H2L4B7_ORYLA	Mtor	ENSORLP00000000606	ENSORLP00000000608	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family.	Serine/threonine-protein kinase TOR.	0.968
H2L4B7_ORYLA	atg5	ENSORLP00000000606	ENSORLP00000019636	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.459
H2L4B7_ORYLA	atg7	ENSORLP00000000606	ENSORLP00000037273	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family.	ATG7 autophagy related 7 homolog (S. cerevisiae).	0.415
H2L4B7_ORYLA	kras	ENSORLP00000000606	ENSORLP00000031976	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family.	GTPase KRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (By similarity). Plays an important role in the regulation of cell proliferation.	0.406
H2L4B7_ORYLA	tp53	ENSORLP00000000606	ENSORLP00000008031	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity); Belongs to the p53 family.	0.510
LOC100049419	kras	ENSORLP00000032488	ENSORLP00000031976	Calmodulin.	GTPase KRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (By similarity). Plays an important role in the regulation of cell proliferation.	0.563
LOC100049419	nox1	ENSORLP00000032488	ENSORLP00000041933	Calmodulin.	NADPH oxidase 1.	0.433
LOC100049419	nox4	ENSORLP00000032488	ENSORLP00000013799	Calmodulin.	FAD-binding FR-type domain-containing protein.	0.532
LOC100049422	LOC101160304	ENSORLP00000022187	ENSORLP00000003652	Uncharacterized protein; Belongs to the calmodulin family.	Calreticulin.	0.407
LOC100049422	LOC101162115	ENSORLP00000022187	ENSORLP00000021484	Uncharacterized protein; Belongs to the calmodulin family.	Calreticulin.	0.417
LOC100049422	LOC101169735	ENSORLP00000022187	ENSORLP00000022552	Uncharacterized protein; Belongs to the calmodulin family.	Calreticulin.	0.401
LOC100049422	RASGRF1	ENSORLP00000022187	ENSORLP00000041908	Uncharacterized protein; Belongs to the calmodulin family.	Ras protein specific guanine nucleotide releasing factor 1.	0.419
LOC100049422	kras	ENSORLP00000022187	ENSORLP00000031976	Uncharacterized protein; Belongs to the calmodulin family.	GTPase KRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (By similarity). Plays an important role in the regulation of cell proliferation.	0.563
LOC100049422	nox1	ENSORLP00000022187	ENSORLP00000041933	Uncharacterized protein; Belongs to the calmodulin family.	NADPH oxidase 1.	0.433
LOC100049422	nox4	ENSORLP00000022187	ENSORLP00000013799	Uncharacterized protein; Belongs to the calmodulin family.	FAD-binding FR-type domain-containing protein.	0.538
LOC100049422	rasgrf2	ENSORLP00000022187	ENSORLP00000003975	Uncharacterized protein; Belongs to the calmodulin family.	Ras protein-specific guanine nucleotide-releasing factor 2b.	0.406
LOC101160304	LOC100049422	ENSORLP00000003652	ENSORLP00000022187	Calreticulin.	Uncharacterized protein; Belongs to the calmodulin family.	0.407
LOC101160304	LOC101169735	ENSORLP00000003652	ENSORLP00000022552	Calreticulin.	Calreticulin.	0.901
LOC101160304	atf6	ENSORLP00000003652	ENSORLP00000020863	Calreticulin.	BZIP domain-containing protein.	0.710
LOC101160304	calm3	ENSORLP00000003652	ENSORLP00000008598	Calreticulin.	Calmodulin-A; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.	0.403