(16 nodes) (2018) Germ cells in the teleost fish medaka have an inherent feminizing effect. network (Oryzias latipes)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	actb	Actin, cytoplasmic 1. (434 aa)
	LOC101168921	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (410 aa)
	bmp15	Bone morphogenetic protein 15. (444 aa)
	sox9	HMG box domain-containing protein. (476 aa)
	dazl	RRM domain-containing protein. (217 aa)
	LOC101166143	Growth differentiation factor 9. (435 aa)
	gsdf	Gonadal soma derived factor. (216 aa)
	meioc	Uncharacterized protein. (804 aa)
	LOC100049444	C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (375 aa)
	ddx4	Uncharacterized protein; Belongs to the DEAD box helicase family. (727 aa)
	LOC101162601	Uncharacterized protein. (1124 aa)
	LOC101174651	Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens. (518 aa)
	cyp19b	Aromatase B; Belongs to the cytochrome P450 family. (499 aa)
	foxl2	Forkhead box L2. (306 aa)
	dmy	Doublesex- and mab-3-related transcription factor 1; Transcription factor that acts both as a transcription. (283 aa)
	nanos3	NANOS3; Belongs to the nanos family. (201 aa)

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC101166143	LOC101174651	ENSORLP00000042760	ENSORLP00000003688	Growth differentiation factor 9.	Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens.	0.671
LOC101166143	bmp15	ENSORLP00000042760	ENSORLP00000010817	Growth differentiation factor 9.	Bone morphogenetic protein 15.	0.823
LOC101166143	cyp19b	ENSORLP00000042760	ENSORLP00000006985	Growth differentiation factor 9.	Aromatase B; Belongs to the cytochrome P450 family.	0.569
LOC101166143	dazl	ENSORLP00000042760	ENSORLP00000042767	Growth differentiation factor 9.	RRM domain-containing protein.	0.583
LOC101166143	dmy	ENSORLP00000042760	ENSORLP00000025381	Growth differentiation factor 9.	Doublesex- and mab-3-related transcription factor 1; Transcription factor that acts both as a transcription.	0.559
LOC101166143	foxl2	ENSORLP00000042760	ENSORLP00000025058	Growth differentiation factor 9.	Forkhead box L2.	0.630
LOC101166143	gsdf	ENSORLP00000042760	ENSORLP00000042059	Growth differentiation factor 9.	Gonadal soma derived factor.	0.533
LOC101166143	sox9	ENSORLP00000042760	ENSORLP00000009985	Growth differentiation factor 9.	HMG box domain-containing protein.	0.503
LOC101168921	LOC101174651	ENSORLP00000011676	ENSORLP00000003688	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens.	0.461
LOC101168921	dmy	ENSORLP00000011676	ENSORLP00000025381	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Doublesex- and mab-3-related transcription factor 1; Transcription factor that acts both as a transcription.	0.510
LOC101168921	sox9	ENSORLP00000011676	ENSORLP00000009985	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	HMG box domain-containing protein.	0.416
LOC101174651	LOC101166143	ENSORLP00000003688	ENSORLP00000042760	Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens.	Growth differentiation factor 9.	0.671
LOC101174651	LOC101168921	ENSORLP00000003688	ENSORLP00000011676	Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens.	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	0.461
LOC101174651	actb	ENSORLP00000003688	ENSORLP00000031145	Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens.	Actin, cytoplasmic 1.	0.461
LOC101174651	bmp15	ENSORLP00000003688	ENSORLP00000010817	Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens.	Bone morphogenetic protein 15.	0.666
LOC101174651	cyp19b	ENSORLP00000003688	ENSORLP00000006985	Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens.	Aromatase B; Belongs to the cytochrome P450 family.	0.903
LOC101174651	dazl	ENSORLP00000003688	ENSORLP00000042767	Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens.	RRM domain-containing protein.	0.424
LOC101174651	dmy	ENSORLP00000003688	ENSORLP00000025381	Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens.	Doublesex- and mab-3-related transcription factor 1; Transcription factor that acts both as a transcription.	0.897
LOC101174651	foxl2	ENSORLP00000003688	ENSORLP00000025058	Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens.	Forkhead box L2.	0.855
LOC101174651	gsdf	ENSORLP00000003688	ENSORLP00000042059	Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens.	Gonadal soma derived factor.	0.725