STRINGSTRING
LOC101162998 LOC101162998 zeb2 zeb2 ctbp1 ctbp1 ccnd1 ccnd1 ccnb2 ccnb2 LOC101162314 LOC101162314 wnt3 wnt3 wnt4 wnt4 prmt5 prmt5 kdm1a kdm1a ccnb1 ccnb1 glb1l2 glb1l2 LOC101157386 LOC101157386 zbtb16 zbtb16 sall4 sall4 LOC101172034 LOC101172034 foxa2 foxa2 LOC101168009 LOC101168009 ccn2 ccn2 glb1 glb1 bbs1 bbs1 dmy dmy LOC101171501 LOC101171501 nkx6-1 nkx6-1 JDP2 JDP2 neurod1 neurod1 trh trh manf manf nanog nanog ANO1 ANO1 Nedd4 Nedd4 ENSORLP00000032832 ENSORLP00000032832 LOC100049444 LOC100049444 ano1 ano1 sumo4 sumo4 LOC101164480 LOC101164480 CUL3 CUL3 LOC101170361 LOC101170361 fgf18 fgf18 fshr fshr ctbp2 ctbp2 trim32 trim32 pax8 pax8 lhx1 lhx1 cdca2 cdca2 mycn mycn smurf1 smurf1 glis2 glis2 foxo1 foxo1 LOC101167278 LOC101167278 LOC101157208 LOC101157208 gli1 gli1 LOC101158706 LOC101158706 gfra1 gfra1 pias4 pias4 LOC101165696 LOC101165696 pax7 pax7 LOC101171858 LOC101171858 tnpo1 tnpo1 glis3 glis3 LOC101171257 LOC101171257 trpv4 trpv4 SRC SRC LOC101161389 LOC101161389 tp53 tp53 rps6 rps6 LOC101168811 LOC101168811 klf4 klf4 ptf1a ptf1a pdgfa pdgfa sufu sufu LOC101164388 LOC101164388 HDAC3 HDAC3 LOC101160236 LOC101160236 nanos2 nanos2 sumo2-2 sumo2-2 tshr tshr LOC101172920 LOC101172920 nanos3 nanos3 gdnf gdnf sox9 sox9
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC101162998Uncharacterized protein. (825 aa)
zeb2Zinc finger E-box binding homeobox 2b. (1193 aa)
ctbp1C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (443 aa)
ccnd1Cyclin D1; Belongs to the cyclin family. (292 aa)
ccnb2G2/mitotic-specific cyclin-B2; Essential for the control of the cell cycle at the G2/M (mitosis) transition; Belongs to the cyclin family. Cyclin AB subfamily. (387 aa)
LOC101162314Inhibitor of DNA binding 4. (138 aa)
wnt3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
wnt4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
prmt5Protein arginine N-methyltransferase 5; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA); Belongs to the class I-like SAM-binding methyltransferase superfamily. (651 aa)
kdm1aLysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (860 aa)
ccnb1G2/mitotic-specific cyclin-B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition; Belongs to the cyclin family. Cyclin AB subfamily. (404 aa)
glb1l2Beta-galactosidase. (640 aa)
LOC101157386Beta-galactosidase. (604 aa)
zbtb16PLZFa. (664 aa)
sall4Spalt-like transcription factor 4. (1059 aa)
LOC101172034Galactosidase, beta 1-like; Belongs to the glycosyl hydrolase 35 family. (631 aa)
foxa2Hepatocyte nuclear factor 3-beta; Transcription activator for a number of liver genes. Interacts with the cis-acting regulatory regions of these genes (By similarity). (415 aa)
LOC101168009Jun dimerization protein 2b. (191 aa)
ccn2Cellular communication network factor 2a. (346 aa)
glb1Beta-galactosidase. (653 aa)
bbs1Bardet-Biedl syndrome 1. (583 aa)
dmyDoublesex- and mab-3-related transcription factor 1; Transcription factor that acts both as a transcription. (283 aa)
LOC101171501Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
nkx6-1NK6 homeobox 1. (414 aa)
JDP2Jun dimerization protein 2. (198 aa)
neurod1Neurogenic differentiation factor. (350 aa)
trhUncharacterized protein. (292 aa)
manfMesencephalic astrocyte-derived neurotrophic factor. (180 aa)
nanogHomeobox domain-containing protein. (420 aa)
ANO1Anoctamin. (949 aa)
Nedd4Uncharacterized protein. (403 aa)
ENSORLP00000032832BHLH domain-containing protein. (199 aa)
LOC100049444C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (375 aa)
ano1Anoctamin. (990 aa)
sumo4Small ubiquitin-related modifier. (101 aa)
LOC101164480Tyrosine-protein kinase. (551 aa)
CUL3Cullin 3; Belongs to the cullin family. (766 aa)
LOC101170361Thyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (756 aa)
fgf18Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family. (210 aa)
fshrThyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (687 aa)
ctbp2Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (458 aa)
trim32Tripartite motif containing 32. (622 aa)
pax8Paired box 8. (444 aa)
lhx1LIM homeobox 1a. (406 aa)
cdca2PP1-binding domain-containing protein. (758 aa)
mycnMYCN proto-oncogene, bHLH transcription factor. (451 aa)
smurf1E3 ubiquitin-protein ligase. (728 aa)
glis2GLIS family zinc finger 2b. (477 aa)
foxo1Fork-head domain-containing protein. (655 aa)
LOC101167278Uncharacterized protein. (1130 aa)
LOC101157208Snail family zinc finger 1a. (256 aa)
gli1GLI family zinc finger 1. (1467 aa)
LOC101158706C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (448 aa)
gfra1GDNF family receptor alpha-1; Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. Belongs to the GDNFR family. (466 aa)
pias4Protein inhibitor of activated STAT, 4a. (503 aa)
LOC101165696Lysine (K)-specific demethylase 4C. (1571 aa)
pax7Uncharacterized protein. (524 aa)
LOC101171858GDNF family receptor alpha-1; Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. Belongs to the GDNFR family. (490 aa)
tnpo1Transportin 1. (773 aa)
glis3Glis3. (783 aa)
LOC101171257Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (343 aa)
trpv4Transient receptor potential cation channel, subfamily V, member 4; Belongs to the transient receptor (TC 1.A.4) family. (871 aa)
SRCTyrosine-protein kinase. (544 aa)
LOC101161389Solute carrier family 5 member 5; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (629 aa)
tp53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity); Belongs to the p53 family. (352 aa)
rps6Ribosomal protein S6. (308 aa)
LOC101168811Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (448 aa)
klf4Kruppel-like factor 4. (425 aa)
ptf1aPancreas associated transcription factor 1a. (268 aa)
pdgfaPlatelet-derived growth factor alpha polypeptide b; Belongs to the PDGF/VEGF growth factor family. (227 aa)
sufuSuppressor of fused homolog. (471 aa)
LOC101164388Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (703 aa)
HDAC3Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (440 aa)
LOC101160236Snail family zinc finger 1b. (266 aa)
nanos2Nanos-type domain-containing protein; Belongs to the nanos family. (155 aa)
sumo2-2Small ubiquitin-related modifier. (95 aa)
tshrThyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (781 aa)
LOC101172920CULLIN_2 domain-containing protein; Belongs to the cullin family. (746 aa)
nanos3NANOS3; Belongs to the nanos family. (201 aa)
gdnfGlial cell line-derived neurotrophic factor; Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high- affinity dopamine uptake. (265 aa)
sox9HMG box domain-containing protein. (476 aa)
Your Current Organism:
Oryzias latipes
NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka
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