(46 nodes) (2021) A defective interleukin-17 receptor A1 causes weight loss and intestinal metabolism-related gene downregulation in Japanese medaka, Oryzias latipes. network (Oryzias latipes)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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Your Input:
	LOC101168538	Elastase 2; Belongs to the peptidase S1 family. (266 aa)
	notch1	Notch receptor 1b. (2507 aa)
	traf6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (569 aa)
	LOC101157631	Transforming growth factor beta; Belongs to the TGF-beta family. (444 aa)
	neu1	Sialidase 1. (393 aa)
	LOC101155037	Transforming growth factor beta; Belongs to the TGF-beta family. (420 aa)
	LOC101169415	UTP--glucose-1-phosphate uridylyltransferase. (504 aa)
	aoc1	Amine oxidase. (742 aa)
	stat3	Signal transducer and activator of transcription. (785 aa)
	LOC101168781	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (266 aa)
	LOC101170426	Pyruvate kinase; Belongs to the pyruvate kinase family. (530 aa)
	mvk	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (396 aa)
	eef1a	Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. (461 aa)
	LOC101155815	Transforming growth factor beta; Belongs to the TGF-beta family. (408 aa)
	LOC101168921	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (410 aa)
	mvd	Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes. (396 aa)
	mogat2	Monoacylglycerol O-acyltransferase 2. (335 aa)
	srf	Serum response factor b. (611 aa)
	acat2	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family. (394 aa)
	LOC101170748	Pyruvate kinase; Belongs to the pyruvate kinase family. (550 aa)
	LOC101169721	Apolipoprotein A-Ib. (323 aa)
	tgfb3	Transforming growth factor beta; Belongs to the TGF-beta family. (405 aa)
	LOC100125499	3-hydroxy-3-methylglutaryl coenzyme A reductase. (865 aa)
	LOC101165526	Cathepsin Bb; Belongs to the peptidase C1 family. (330 aa)
	il17rd	Interleukin 17 receptor D. (809 aa)
	H2N0C8_ORYLA	Cytochrome P450, family 51; Belongs to the cytochrome P450 family. (200 aa)
	LOC101162393	Phospholipase A2, group XIIB. (286 aa)
	sox7	Uncharacterized protein. (407 aa)
	il-17a/f-1	Interleukin-17A/F-1. (152 aa)
	actb	Actin, cytoplasmic 1. (434 aa)
	hmgcs1	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (513 aa)
	pla2g1b	Phospholipase A(2). (149 aa)
	LOC105358811	MADS-box domain-containing protein. (552 aa)
	Cxcl13	SCY domain-containing protein. (91 aa)
	ENSORLP00000034044	Interleukin; Belongs to the IL-15/IL-21 family. (168 aa)
	il17rb	SEFIR domain-containing protein. (434 aa)
	LOC101172927	RAR-related orphan receptor C. (532 aa)
	PLA2G12B	Phospholipase A2 group XIIB. (214 aa)
	il17rc	SEFIR domain-containing protein. (703 aa)
	il17re	Uncharacterized protein. (781 aa)
	s100a1	Protein S100; Belongs to the S-100 family. (99 aa)
	fli1	Fli-1 proto-oncogene, ETS transcription factor a. (458 aa)
	man2b1	Alpha-mannosidase. (998 aa)
	LOC101161188	Pyruvate kinase; Belongs to the pyruvate kinase family. (543 aa)
	il-17n	Uncharacterized protein. (206 aa)
	il-17a/f-2	Uncharacterized protein. (183 aa)

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Cxcl13	il-17a/f-1	ENSORLP00000033122	ENSORLP00000028491	SCY domain-containing protein.	Interleukin-17A/F-1.	0.490
Cxcl13	il-17a/f-2	ENSORLP00000033122	ENSORLP00000045881	SCY domain-containing protein.	Uncharacterized protein.	0.482
Cxcl13	il17rb	ENSORLP00000033122	ENSORLP00000034493	SCY domain-containing protein.	SEFIR domain-containing protein.	0.457
Cxcl13	il17rc	ENSORLP00000033122	ENSORLP00000039012	SCY domain-containing protein.	SEFIR domain-containing protein.	0.410
Cxcl13	il17re	ENSORLP00000033122	ENSORLP00000041144	SCY domain-containing protein.	Uncharacterized protein.	0.408
Cxcl13	pla2g1b	ENSORLP00000033122	ENSORLP00000031903	SCY domain-containing protein.	Phospholipase A(2).	0.404
Cxcl13	s100a1	ENSORLP00000033122	ENSORLP00000042119	SCY domain-containing protein.	Protein S100; Belongs to the S-100 family.	0.437
ENSORLP00000034044	il-17a/f-1	ENSORLP00000034044	ENSORLP00000028491	Interleukin; Belongs to the IL-15/IL-21 family.	Interleukin-17A/F-1.	0.621
ENSORLP00000034044	il-17a/f-2	ENSORLP00000034044	ENSORLP00000045881	Interleukin; Belongs to the IL-15/IL-21 family.	Uncharacterized protein.	0.622
ENSORLP00000034044	il-17n	ENSORLP00000034044	ENSORLP00000045730	Interleukin; Belongs to the IL-15/IL-21 family.	Uncharacterized protein.	0.509
ENSORLP00000034044	il17rc	ENSORLP00000034044	ENSORLP00000039012	Interleukin; Belongs to the IL-15/IL-21 family.	SEFIR domain-containing protein.	0.450
ENSORLP00000034044	mvk	ENSORLP00000034044	ENSORLP00000009293	Interleukin; Belongs to the IL-15/IL-21 family.	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily.	0.452
H2N0C8_ORYLA	LOC100125499	ENSORLP00000024830	ENSORLP00000021654	Cytochrome P450, family 51; Belongs to the cytochrome P450 family.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.907
H2N0C8_ORYLA	acat2	ENSORLP00000024830	ENSORLP00000016574	Cytochrome P450, family 51; Belongs to the cytochrome P450 family.	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	0.748
H2N0C8_ORYLA	hmgcs1	ENSORLP00000024830	ENSORLP00000031232	Cytochrome P450, family 51; Belongs to the cytochrome P450 family.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.983
H2N0C8_ORYLA	mvd	ENSORLP00000024830	ENSORLP00000011725	Cytochrome P450, family 51; Belongs to the cytochrome P450 family.	Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes.	0.852
H2N0C8_ORYLA	mvk	ENSORLP00000024830	ENSORLP00000009293	Cytochrome P450, family 51; Belongs to the cytochrome P450 family.	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily.	0.727
LOC100125499	H2N0C8_ORYLA	ENSORLP00000021654	ENSORLP00000024830	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Cytochrome P450, family 51; Belongs to the cytochrome P450 family.	0.907
LOC100125499	LOC101169415	ENSORLP00000021654	ENSORLP00000003672	3-hydroxy-3-methylglutaryl coenzyme A reductase.	UTP--glucose-1-phosphate uridylyltransferase.	0.405
LOC100125499	acat2	ENSORLP00000021654	ENSORLP00000016574	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	0.418