(19 nodes) (2021) A brief review of vertebrate sex evolution with a pledge for integrative research: towards sexomics. network (Oryzias latipes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	H2L503_ORYLA	Histone H3; Belongs to the histone H3 family. (100 aa)
	H3-2	Histone H3; Belongs to the histone H3 family. (139 aa)
	LOC100049233	Androgen receptor beta subtype. (744 aa)
	ar-alpha	Uncharacterized protein. (687 aa)
	sox9	HMG box domain-containing protein. (476 aa)
	gdf6	Growth differentiation factor 6b. (409 aa)
	stat3	Signal transducer and activator of transcription. (785 aa)
	H2LD49_ORYLA	Histone H3; Belongs to the histone H3 family. (134 aa)
	LOC101159638	Histone H3; Belongs to the histone H3 family. (136 aa)
	H2L6K8_ORYLA	Histone H3; Belongs to the histone H3 family. (107 aa)
	H2L5L2_ORYLA	Histone H3; Belongs to the histone H3 family. (125 aa)
	H2L5K1_ORYLA	Histone H3; Belongs to the histone H3 family. (136 aa)
	H3-3B	Histone H3; Belongs to the histone H3 family. (140 aa)
	ENSORLP00000043059	Histone H3; Belongs to the histone H3 family. (132 aa)
	gsdf	Gonadal soma derived factor. (216 aa)
	ENSORLP00000041905	Histone H3; Belongs to the histone H3 family. (101 aa)
	dmy	Doublesex- and mab-3-related transcription factor 1; Transcription factor that acts both as a transcription. (283 aa)
	rspo1	Uncharacterized protein. (270 aa)
	irf9	IRF tryptophan pentad repeat domain-containing protein. (435 aa)

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC100049233	ar-alpha	ENSORLP00000011941	ENSORLP00000010323	Androgen receptor beta subtype.	Uncharacterized protein.	0.908
LOC100049233	dmy	ENSORLP00000011941	ENSORLP00000025381	Androgen receptor beta subtype.	Doublesex- and mab-3-related transcription factor 1; Transcription factor that acts both as a transcription.	0.568
LOC100049233	sox9	ENSORLP00000011941	ENSORLP00000009985	Androgen receptor beta subtype.	HMG box domain-containing protein.	0.481
ar-alpha	LOC100049233	ENSORLP00000010323	ENSORLP00000011941	Uncharacterized protein.	Androgen receptor beta subtype.	0.908
ar-alpha	dmy	ENSORLP00000010323	ENSORLP00000025381	Uncharacterized protein.	Doublesex- and mab-3-related transcription factor 1; Transcription factor that acts both as a transcription.	0.569
ar-alpha	sox9	ENSORLP00000010323	ENSORLP00000009985	Uncharacterized protein.	HMG box domain-containing protein.	0.410
dmy	LOC100049233	ENSORLP00000025381	ENSORLP00000011941	Doublesex- and mab-3-related transcription factor 1; Transcription factor that acts both as a transcription.	Androgen receptor beta subtype.	0.568
dmy	ar-alpha	ENSORLP00000025381	ENSORLP00000010323	Doublesex- and mab-3-related transcription factor 1; Transcription factor that acts both as a transcription.	Uncharacterized protein.	0.569
dmy	gsdf	ENSORLP00000025381	ENSORLP00000042059	Doublesex- and mab-3-related transcription factor 1; Transcription factor that acts both as a transcription.	Gonadal soma derived factor.	0.823
dmy	irf9	ENSORLP00000025381	ENSORLP00000016713	Doublesex- and mab-3-related transcription factor 1; Transcription factor that acts both as a transcription.	IRF tryptophan pentad repeat domain-containing protein.	0.415
dmy	rspo1	ENSORLP00000025381	ENSORLP00000018369	Doublesex- and mab-3-related transcription factor 1; Transcription factor that acts both as a transcription.	Uncharacterized protein.	0.665
dmy	sox9	ENSORLP00000025381	ENSORLP00000009985	Doublesex- and mab-3-related transcription factor 1; Transcription factor that acts both as a transcription.	HMG box domain-containing protein.	0.892
gdf6	irf9	ENSORLP00000009855	ENSORLP00000016713	Growth differentiation factor 6b.	IRF tryptophan pentad repeat domain-containing protein.	0.482
gsdf	dmy	ENSORLP00000042059	ENSORLP00000025381	Gonadal soma derived factor.	Doublesex- and mab-3-related transcription factor 1; Transcription factor that acts both as a transcription.	0.823
gsdf	irf9	ENSORLP00000042059	ENSORLP00000016713	Gonadal soma derived factor.	IRF tryptophan pentad repeat domain-containing protein.	0.427
gsdf	rspo1	ENSORLP00000042059	ENSORLP00000018369	Gonadal soma derived factor.	Uncharacterized protein.	0.606
gsdf	sox9	ENSORLP00000042059	ENSORLP00000009985	Gonadal soma derived factor.	HMG box domain-containing protein.	0.612
irf9	dmy	ENSORLP00000016713	ENSORLP00000025381	IRF tryptophan pentad repeat domain-containing protein.	Doublesex- and mab-3-related transcription factor 1; Transcription factor that acts both as a transcription.	0.415
irf9	gdf6	ENSORLP00000016713	ENSORLP00000009855	IRF tryptophan pentad repeat domain-containing protein.	Growth differentiation factor 6b.	0.482
irf9	gsdf	ENSORLP00000016713	ENSORLP00000042059	IRF tryptophan pentad repeat domain-containing protein.	Gonadal soma derived factor.	0.427