(15 nodes) (2022) Generation of Lens Progenitor Cells and Lentoid Bodies from Pluripotent Stem Cells: Novel Tools for Human Lens Development and Ocular Disease Etiology. network (Oryzias latipes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	LOC101155571-4	Histone H2B 1/2. (124 aa)
	LOC101155571-3	Histone H2B 1/2. (124 aa)
	wnt3a	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
	pik3c3	Phosphatidylinositol 3-kinase catalytic subunit type 3. (884 aa)
	dnmt1	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1496 aa)
	LOC101155571-2	Histone H2B 1/2. (124 aa)
	LOC101155571	Histone H2B; Belongs to the histone H2B family. (124 aa)
	LOC101161368	Major intrinsic protein of lens fiber a; Belongs to the MIP/aquaporin (TC 1.A.8) family. (263 aa)
	met	MET proto-oncogene, receptor tyrosine kinase. (1403 aa)
	ascl1	Achaete-scute family bHLH transcription factor 1a. (178 aa)
	pou2f1	POU domain protein. (715 aa)
	LOC101159648	Keratin 15; Belongs to the intermediate filament family. (439 aa)
	LOC101156250	Major intrinsic protein of lens fiber b; Belongs to the MIP/aquaporin (TC 1.A.8) family. (263 aa)
	bfsp2	Beaded filament structural protein 2, phakinin; Belongs to the intermediate filament family. (423 aa)
	tp53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity); Belongs to the p53 family. (352 aa)

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC101155571	dnmt1	ENSORLP00000030604	ENSORLP00000034016	Histone H2B; Belongs to the histone H2B family.	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.586
LOC101155571-2	dnmt1	ENSORLP00000032177	ENSORLP00000034016	Histone H2B 1/2.	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.589
LOC101155571-3	dnmt1	ENSORLP00000040266	ENSORLP00000034016	Histone H2B 1/2.	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.589
LOC101155571-4	dnmt1	ENSORLP00000043965	ENSORLP00000034016	Histone H2B 1/2.	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.567
dnmt1	LOC101155571	ENSORLP00000034016	ENSORLP00000030604	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Histone H2B; Belongs to the histone H2B family.	0.586
dnmt1	LOC101155571-2	ENSORLP00000034016	ENSORLP00000032177	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Histone H2B 1/2.	0.589
dnmt1	LOC101155571-3	ENSORLP00000034016	ENSORLP00000040266	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Histone H2B 1/2.	0.589
dnmt1	LOC101155571-4	ENSORLP00000034016	ENSORLP00000043965	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Histone H2B 1/2.	0.567
dnmt1	tp53	ENSORLP00000034016	ENSORLP00000008031	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity); Belongs to the p53 family.	0.808
tp53	dnmt1	ENSORLP00000008031	ENSORLP00000034016	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity); Belongs to the p53 family.	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.808