(19 nodes) (2023) Putative adverse outcome pathways for silver nanoparticle toxicity on mammalian male reproductive system: a literature review. network (Oryzias latipes)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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Your Input:
	sod2	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (226 aa)
	LOC101166369	Tight junction protein 1a; Belongs to the MAGUK family. (1748 aa)
	LOC101156378	Uncharacterized protein; Belongs to the peptidase C14A family. (287 aa)
	casp9	Caspase 9, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (438 aa)
	hsd17b3	Hydroxysteroid (17-beta) dehydrogenase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (349 aa)
	xrcc2	X-ray repair cross complementing 2. (313 aa)
	LOC101165110	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
	tspo	Translocator protein. (161 aa)
	cyp17	Steroid 17-alpha-hydroxylase/17,20 lyase; Conversion of pregnenolone and progesterone to their 17- alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction; Belongs to the cytochrome P450 family. (595 aa)
	LOC101171965	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
	bcl2	BCL2 apoptosis regulator b. (202 aa)
	LOC101160233	Tight junction protein 1b; Belongs to the MAGUK family. (1856 aa)
	star	Steroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. (285 aa)
	LOC101166173	Claudin 11a. (219 aa)
	casp3	Uncharacterized protein; Belongs to the peptidase C14A family. (290 aa)
	LOC100049265	Caspase 3, apoptosis-related cysteine peptidase a; Belongs to the peptidase C14A family. (265 aa)
	tp53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity); Belongs to the p53 family. (352 aa)
	hsd17b1	Hydroxysteroid (17-beta) dehydrogenase 1. (291 aa)
	cldn11	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (219 aa)

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC100049265	LOC101160233	ENSORLP00000010098	ENSORLP00000027536	Caspase 3, apoptosis-related cysteine peptidase a; Belongs to the peptidase C14A family.	Tight junction protein 1b; Belongs to the MAGUK family.	0.443
LOC100049265	LOC101165110	ENSORLP00000010098	ENSORLP00000045850	Caspase 3, apoptosis-related cysteine peptidase a; Belongs to the peptidase C14A family.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.778
LOC100049265	LOC101166369	ENSORLP00000010098	ENSORLP00000029048	Caspase 3, apoptosis-related cysteine peptidase a; Belongs to the peptidase C14A family.	Tight junction protein 1a; Belongs to the MAGUK family.	0.443
LOC100049265	LOC101171965	ENSORLP00000010098	ENSORLP00000023224	Caspase 3, apoptosis-related cysteine peptidase a; Belongs to the peptidase C14A family.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.778
LOC100049265	bcl2	ENSORLP00000010098	ENSORLP00000021005	Caspase 3, apoptosis-related cysteine peptidase a; Belongs to the peptidase C14A family.	BCL2 apoptosis regulator b.	0.732
LOC100049265	casp3	ENSORLP00000010098	ENSORLP00000010793	Caspase 3, apoptosis-related cysteine peptidase a; Belongs to the peptidase C14A family.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.902
LOC100049265	casp9	ENSORLP00000010098	ENSORLP00000040536	Caspase 3, apoptosis-related cysteine peptidase a; Belongs to the peptidase C14A family.	Caspase 9, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	0.970
LOC100049265	tp53	ENSORLP00000010098	ENSORLP00000008031	Caspase 3, apoptosis-related cysteine peptidase a; Belongs to the peptidase C14A family.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity); Belongs to the p53 family.	0.712
LOC101156378	LOC101160233	ENSORLP00000040113	ENSORLP00000027536	Uncharacterized protein; Belongs to the peptidase C14A family.	Tight junction protein 1b; Belongs to the MAGUK family.	0.443
LOC101156378	LOC101165110	ENSORLP00000040113	ENSORLP00000045850	Uncharacterized protein; Belongs to the peptidase C14A family.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.780
LOC101156378	LOC101166369	ENSORLP00000040113	ENSORLP00000029048	Uncharacterized protein; Belongs to the peptidase C14A family.	Tight junction protein 1a; Belongs to the MAGUK family.	0.443
LOC101156378	LOC101171965	ENSORLP00000040113	ENSORLP00000023224	Uncharacterized protein; Belongs to the peptidase C14A family.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.780
LOC101156378	bcl2	ENSORLP00000040113	ENSORLP00000021005	Uncharacterized protein; Belongs to the peptidase C14A family.	BCL2 apoptosis regulator b.	0.732
LOC101156378	casp9	ENSORLP00000040113	ENSORLP00000040536	Uncharacterized protein; Belongs to the peptidase C14A family.	Caspase 9, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	0.974
LOC101156378	tp53	ENSORLP00000040113	ENSORLP00000008031	Uncharacterized protein; Belongs to the peptidase C14A family.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity); Belongs to the p53 family.	0.694
LOC101160233	LOC100049265	ENSORLP00000027536	ENSORLP00000010098	Tight junction protein 1b; Belongs to the MAGUK family.	Caspase 3, apoptosis-related cysteine peptidase a; Belongs to the peptidase C14A family.	0.443
LOC101160233	LOC101156378	ENSORLP00000027536	ENSORLP00000040113	Tight junction protein 1b; Belongs to the MAGUK family.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.443
LOC101160233	LOC101166173	ENSORLP00000027536	ENSORLP00000014348	Tight junction protein 1b; Belongs to the MAGUK family.	Claudin 11a.	0.765
LOC101160233	LOC101166369	ENSORLP00000027536	ENSORLP00000029048	Tight junction protein 1b; Belongs to the MAGUK family.	Tight junction protein 1a; Belongs to the MAGUK family.	0.903
LOC101160233	casp3	ENSORLP00000027536	ENSORLP00000010793	Tight junction protein 1b; Belongs to the MAGUK family.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.443