(33 nodes) (2023) Regulation of Adenine Nucleotide Metabolism by Adenylate Kinase Isozymes: Physiological Roles and Diseases. network (Oryzias latipes)

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second shell of interactors

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a 3D structure is known or predicted

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experimentally determined

Predicted Interactions

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Your Input:
	ak2	Adenylate kinase 2, mitochondrial; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis. (249 aa)
	HK1	Hexokinase 1. (919 aa)
	CKB	Creatine kinase B; Belongs to the ATP:guanido phosphotransferase family. (407 aa)
	H2L4B7_ORYLA	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family. (737 aa)
	Mtor	Serine/threonine-protein kinase TOR. (1023 aa)
	LOC101164721	Creatine kinase, mitochondrial 1A; Belongs to the ATP:guanido phosphotransferase family. (417 aa)
	CKM	Uncharacterized protein; Belongs to the ATP:guanido phosphotransferase family. (421 aa)
	LOC101165163	Hypoxia inducible factor 1 subunit alpha, like. (652 aa)
	CKMT2	Creatine kinase, mitochondrial 2; Belongs to the ATP:guanido phosphotransferase family. (414 aa)
	LOC101168720	Glycogen synthase kinase 3 alpha a; Belongs to the protein kinase superfamily. (438 aa)
	ak4	GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. (224 aa)
	ak3	GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. (224 aa)
	LOC101156878	Hexokinase 1. (918 aa)
	arnt	Aryl hydrocarbon receptor nuclear translocator. (780 aa)
	ak7	Adenylate kinase 7b. (675 aa)
	rps14	Ribosomal protein S14; Belongs to the universal ribosomal protein uS11 family. (151 aa)
	LOC101166309	Hexokinase 2. (916 aa)
	ak8	Adenylate kinase 8; Belongs to the adenylate kinase family. (463 aa)
	atf6	BZIP domain-containing protein. (645 aa)
	gsk3b	Glycogen synthase kinase 3 beta, genome duplicate a. (216 aa)
	atf3	Activating transcription factor 3. (212 aa)
	H2N0U4_ORYLA	Dpy-30 histone methyltransferase complex regulatory subunit. (88 aa)
	LOC101167262	Uncharacterized protein; Belongs to the ATP:guanido phosphotransferase family. (381 aa)
	hif1a	Hypoxia inducible factor 1 subunit alpha a. (750 aa)
	LOC101165960	Phosphotransferase. (492 aa)
	braf	B-Raf proto-oncogene, serine/threonine kinase. (823 aa)
	LOC101169907	Uncharacterized protein; Belongs to the ATP:guanido phosphotransferase family. (408 aa)
	LOC101166239	Creatine kinase, muscle a; Belongs to the ATP:guanido phosphotransferase family. (381 aa)
	DUSP26	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (197 aa)
	fadd	Uncharacterized protein. (192 aa)
	ak5	Adenylate kinase 5. (613 aa)
	ak1	Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. (201 aa)
	LOC101160344	Glycogen synthase kinase 3 alpha b; Belongs to the protein kinase superfamily. (480 aa)

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CKB	LOC101166239	ENSORLP00000000553	ENSORLP00000038248	Creatine kinase B; Belongs to the ATP:guanido phosphotransferase family.	Creatine kinase, muscle a; Belongs to the ATP:guanido phosphotransferase family.	0.488
H2L4B7_ORYLA	Mtor	ENSORLP00000000606	ENSORLP00000000608	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family.	Serine/threonine-protein kinase TOR.	0.968
H2N0U4_ORYLA	ak1	ENSORLP00000025020	ENSORLP00000044730	Dpy-30 histone methyltransferase complex regulatory subunit.	Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.	0.418
H2N0U4_ORYLA	ak2	ENSORLP00000025020	ENSORLP00000009260	Dpy-30 histone methyltransferase complex regulatory subunit.	Adenylate kinase 2, mitochondrial; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis.	0.446
H2N0U4_ORYLA	ak3	ENSORLP00000025020	ENSORLP00000013053	Dpy-30 histone methyltransferase complex regulatory subunit.	GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.	0.446
H2N0U4_ORYLA	ak4	ENSORLP00000025020	ENSORLP00000012535	Dpy-30 histone methyltransferase complex regulatory subunit.	GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.	0.446
H2N0U4_ORYLA	ak5	ENSORLP00000025020	ENSORLP00000044239	Dpy-30 histone methyltransferase complex regulatory subunit.	Adenylate kinase 5.	0.418
H2N0U4_ORYLA	ak7	ENSORLP00000025020	ENSORLP00000013694	Dpy-30 histone methyltransferase complex regulatory subunit.	Adenylate kinase 7b.	0.446
H2N0U4_ORYLA	ak8	ENSORLP00000025020	ENSORLP00000020802	Dpy-30 histone methyltransferase complex regulatory subunit.	Adenylate kinase 8; Belongs to the adenylate kinase family.	0.446
HK1	LOC101156878	ENSORLP00000000086	ENSORLP00000013070	Hexokinase 1.	Hexokinase 1.	0.900
HK1	LOC101165960	ENSORLP00000000086	ENSORLP00000033399	Hexokinase 1.	Phosphotransferase.	0.904
HK1	LOC101166309	ENSORLP00000000086	ENSORLP00000019339	Hexokinase 1.	Hexokinase 2.	0.901
LOC101156878	HK1	ENSORLP00000013070	ENSORLP00000000086	Hexokinase 1.	Hexokinase 1.	0.900
LOC101156878	LOC101165960	ENSORLP00000013070	ENSORLP00000033399	Hexokinase 1.	Phosphotransferase.	0.904
LOC101156878	LOC101166309	ENSORLP00000013070	ENSORLP00000019339	Hexokinase 1.	Hexokinase 2.	0.901
LOC101165163	arnt	ENSORLP00000002499	ENSORLP00000013228	Hypoxia inducible factor 1 subunit alpha, like.	Aryl hydrocarbon receptor nuclear translocator.	0.920
LOC101165163	hif1a	ENSORLP00000002499	ENSORLP00000032596	Hypoxia inducible factor 1 subunit alpha, like.	Hypoxia inducible factor 1 subunit alpha a.	0.907
LOC101165960	HK1	ENSORLP00000033399	ENSORLP00000000086	Phosphotransferase.	Hexokinase 1.	0.904
LOC101165960	LOC101156878	ENSORLP00000033399	ENSORLP00000013070	Phosphotransferase.	Hexokinase 1.	0.904
LOC101165960	LOC101166309	ENSORLP00000033399	ENSORLP00000019339	Phosphotransferase.	Hexokinase 2.	0.904