STRINGSTRING
tp53 tp53 apln apln dvl1 dvl1 LOC101162905 LOC101162905 ywhaq ywhaq LOC101164480 LOC101164480 LOC101154981 LOC101154981 traf3 traf3 nfkbia nfkbia LOC101160371 LOC101160371 bcl2 bcl2 Traf3ip2 Traf3ip2 PRKCA PRKCA fzd10 fzd10 jag1 jag1 casp8 casp8 gna12 gna12 LOC101156432 LOC101156432 SRC SRC rgs14 rgs14 LOC101160739 LOC101160739 LOC101167049 LOC101167049 Mtor Mtor H2L4B7_ORYLA H2L4B7_ORYLA
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
tp53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity); Belongs to the p53 family. (352 aa)
aplnApelin. (76 aa)
dvl1Dishevelled segment polarity protein 1a. (728 aa)
LOC101162905Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (369 aa)
ywhaqTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide b; Belongs to the 14-3-3 family. (253 aa)
LOC101164480Tyrosine-protein kinase. (551 aa)
LOC101154981Toll-like receptor adaptor molecule 1. (577 aa)
traf3TNF receptor-associated factor. (450 aa)
nfkbiaNuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b. (316 aa)
LOC101160371Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (881 aa)
bcl2BCL2 apoptosis regulator b. (202 aa)
Traf3ip2SEFIR domain-containing protein. (116 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (709 aa)
fzd10Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (578 aa)
jag1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1219 aa)
casp8Uncharacterized protein; Belongs to the peptidase C14A family. (481 aa)
gna12G protein subunit alpha 12. (385 aa)
LOC101156432Zgc:86598; Belongs to the protein kinase superfamily. (392 aa)
SRCTyrosine-protein kinase. (544 aa)
rgs14Regulator of G protein signaling 14a. (579 aa)
LOC101160739Isotocin; Belongs to the vasopressin/oxytocin family. (155 aa)
LOC101167049CD40 ligand; Belongs to the tumor necrosis factor family. (239 aa)
MtorSerine/threonine-protein kinase TOR. (1023 aa)
H2L4B7_ORYLAMechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family. (737 aa)
Your Current Organism:
Oryzias latipes
NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka
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