STRINGSTRING
LOC101166777 LOC101166777 LOC111946846 LOC111946846 parp3 parp3 LOC101174244 LOC101174244 LOC101167049 LOC101167049 LOC101166050 LOC101166050 ikbkg ikbkg ikbkb ikbkb LOC101155367 LOC101155367 pik3r1 pik3r1 lmnb2 lmnb2 LOC101171518 LOC101171518 ctss ctss LOC101155061 LOC101155061 LOC101171361 LOC101171361 LOC101159282 LOC101159282 LOC101174595 LOC101174595 LOC101168213 LOC101168213 map2k2 map2k2 dffa dffa LOC101157952 LOC101157952 LOC101174851 LOC101174851 gadd45a gadd45a LOC101172600 LOC101172600 LOC101168864 LOC101168864 tp53 tp53 LOC101164147 LOC101164147 map2k1 map2k1 traf2 traf2 pdpk1 pdpk1 LOC101169222 LOC101169222 LOC100049265 LOC100049265 LOC101157368 LOC101157368 casp3 casp3 LOC101162428 LOC101162428 PIK3CA PIK3CA LOC101168152 LOC101168152 ern1 ern1 LOC101160250 LOC101160250 LOC101168921 LOC101168921 LOC101171857 LOC101171857 aifm1 aifm1 LOC101161416 LOC101161416 jun jun LOC101172593 LOC101172593 LOC101155144 LOC101155144 ctsc ctsc ctsb ctsb LOC101158728 LOC101158728 LOC100125536 LOC100125536 casp8 casp8 Itpr2 Itpr2 hras hras raf1 raf1 LOC101164919 LOC101164919 tnfsf10 tnfsf10 LOC101159747 LOC101159747 casp2 casp2 tnfrsf1a tnfrsf1a LOC101171789 LOC101171789 CHUK CHUK LOC101172365 LOC101172365 LOC101164896 LOC101164896 LOC101168958 LOC101168958 parp1 parp1 LOC101166422 LOC101166422 LOC101155451 LOC101155451 LOC101167700 LOC101167700 LOC101167985 LOC101167985 LOC101174118 LOC101174118 LOC101155351 LOC101155351 apaf1 apaf1 LOC101174474 LOC101174474 LOC101164922 LOC101164922 LOC101165175 LOC101165175 LOC101165916 LOC101165916 LOC101162015 LOC101162015 pofut2 pofut2 LOC101168255 LOC101168255 lmna lmna cflar cflar endog endog LOC101165186 LOC101165186 LOC101167626 LOC101167626 akt1 akt1 LOC101165526 LOC101165526 H2MSU3_ORYLA H2MSU3_ORYLA LOC101167759 LOC101167759 LOC101175325 LOC101175325 nfkbia nfkbia LOC101171965 LOC101171965 LOC101160956 LOC101160956 H2MXM9_ORYLA H2MXM9_ORYLA LOC101157105 LOC101157105 LOC101163466 LOC101163466 LOC101169541 LOC101169541 LOC101158094 LOC101158094 ctsl ctsl LOC101163728 LOC101163728 Atm Atm LOC101164997 LOC101164997 ripk1 ripk1 LOC101160005 LOC101160005 ctsh ctsh dffb dffb LOC101168799 LOC101168799 LOC101155642 LOC101155642 LOC101154954 LOC101154954 Parp4 Parp4 bad bad map3k5 map3k5 LOC101162579 LOC101162579 ddit3 ddit3 casp7 casp7 LOC101168459 LOC101168459 nfkb1 nfkb1 kras kras LOC101172833 LOC101172833 LOC101159035 LOC101159035 LOC101163042 LOC101163042 LOC101161875 LOC101161875 ENSORLP00000032968 ENSORLP00000032968 LOC101155224 LOC101155224 LOC101162606 LOC101162606 pik3r3 pik3r3 pik3cb pik3cb ptpn13 ptpn13 LOC101168604 LOC101168604 LOC101167041 LOC101167041 LOC101162468 LOC101162468 diablo diablo atf4-2 atf4-2 GADD45B GADD45B c-fos c-fos Sptan1 Sptan1 ntrk1 ntrk1 LOC101165300 LOC101165300 eif2ak3 eif2ak3 ctsz ctsz fas fas LOC101160296 LOC101160296 LOC101162905 LOC101162905 ENSORLP00000039815 ENSORLP00000039815 LOC101166883 LOC101166883 LOC101156378 LOC101156378 LOC101168687 LOC101168687 LOC101159737 LOC101159737 tradd tradd casp9 casp9 LOC101159503 LOC101159503 LOC101168810 LOC101168810 LOC101163842 LOC101163842 fadd fadd dab2ip dab2ip pik3cd pik3cd CASP6 CASP6 LOC101167538 LOC101167538 LOC101155619 LOC101155619 LOC101173230 LOC101173230 LOC101165110 LOC101165110
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC101166777Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (449 aa)
LOC111946846Cathepsin D; Belongs to the peptidase A1 family. (396 aa)
parp3Poly [ADP-ribose] polymerase. (526 aa)
LOC101174244Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
LOC101167049CD40 ligand; Belongs to the tumor necrosis factor family. (239 aa)
LOC101166050Uncharacterized protein. (591 aa)
ikbkgInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (585 aa)
ikbkbInhibitor of nuclear factor kappa B kinase subunit beta. (801 aa)
LOC101155367TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (596 aa)
pik3r1Phosphoinositide-3-kinase, regulatory subunit 1 (alpha). (728 aa)
lmnb2Lamin B2; Belongs to the intermediate filament family. (579 aa)
LOC101171518Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (449 aa)
ctssCathepsin S; Belongs to the peptidase C1 family. (327 aa)
LOC101155061Baculoviral IAP repeat containing 5a. (141 aa)
LOC101171361Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (305 aa)
LOC101159282Diablo, IAP-binding mitochondrial protein a. (249 aa)
LOC101174595Mitogen-activated protein kinase kinase kinase 14a. (866 aa)
LOC101168213BCL2 associated X, apoptosis regulator a. (188 aa)
map2k2Mitogen-activated protein kinase kinase 2a; Belongs to the protein kinase superfamily. (397 aa)
dffaDNA fragmentation factor, alpha polypeptide. (322 aa)
LOC101157952Mitogen-activated protein kinase. (420 aa)
LOC101174851Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
gadd45aRibosomal_L7Ae domain-containing protein. (161 aa)
LOC101172600Baculoviral IAP repeat containing 2. (707 aa)
LOC101168864P53-induced death domain protein 1. (1004 aa)
tp53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity); Belongs to the p53 family. (352 aa)
LOC101164147Nerve growth factor b (beta polypeptide); Belongs to the NGF-beta family. (198 aa)
map2k1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (394 aa)
traf2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (523 aa)
pdpk13-phosphoinositide dependent protein kinase 1b. (568 aa)
LOC101169222Septin-type G domain-containing protein; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (334 aa)
LOC100049265Caspase 3, apoptosis-related cysteine peptidase a; Belongs to the peptidase C14A family. (265 aa)
LOC101157368Nerve growth factor a (beta polypeptide); Belongs to the NGF-beta family. (291 aa)
casp3Uncharacterized protein; Belongs to the peptidase C14A family. (290 aa)
LOC101162428Endoplasmic reticulum to nucleus signaling 2. (963 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
LOC101168152Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
ern1Uncharacterized protein. (1071 aa)
LOC101160250Uncharacterized protein; Belongs to the intermediate filament family. (640 aa)
LOC101168921Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (410 aa)
LOC101171857Component of inhibitor of nuclear factor kappa B kinase complex. (732 aa)
aifm1Apoptosis inducing factor mitochondrion associated 1. (708 aa)
LOC101161416Cathepsin F; Belongs to the peptidase C1 family. (473 aa)
junBZIP domain-containing protein; Belongs to the bZIP family. (306 aa)
LOC101172593Tumor necrosis factor a (TNF superfamily, member 2). (279 aa)
LOC101155144Uncharacterized protein. (466 aa)
ctscCathepsin C; Belongs to the peptidase C1 family. (456 aa)
ctsbCathepsin Ba; Belongs to the peptidase C1 family. (352 aa)
LOC101158728V-rel avian reticuloendotheliosis viral oncogene homolog A. (617 aa)
LOC100125536Uncharacterized protein; Belongs to the peptidase C14A family. (389 aa)
casp8Uncharacterized protein; Belongs to the peptidase C14A family. (481 aa)
Itpr2Inositol 1,4,5-trisphosphate receptor, type 2. (1587 aa)
hrasHRas proto-oncogene, GTPase a. (189 aa)
raf1Raf-1 proto-oncogene, serine/threonine kinase a. (677 aa)
LOC101164919Uncharacterized protein; Belongs to the peptidase C2 family. (700 aa)
tnfsf10TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (281 aa)
LOC101159747Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (389 aa)
casp2Caspase 2, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (501 aa)
tnfrsf1aTumor necrosis factor receptor superfamily, member 1a. (385 aa)
LOC101171789Cathepsin L.1; Belongs to the peptidase C1 family. (339 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (765 aa)
LOC101172365TNF superfamily member 10; Belongs to the tumor necrosis factor family. (280 aa)
LOC101164896Uncharacterized protein. (688 aa)
LOC101168958Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (397 aa)
parp1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1015 aa)
LOC101166422ADP-ribosylation factor 2b. (976 aa)
LOC101155451Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (482 aa)
LOC101167700Inositol 1,4,5-trisphosphate receptor, type 1a. (2664 aa)
LOC101167985Si:ch211-1i11.3. (1331 aa)
LOC101174118Growth arrest and DNA-damage-inducible, gamma b, tandem duplicate 1. (154 aa)
LOC101155351Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (450 aa)
apaf1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1235 aa)
LOC101174474Si:dkey-33c12.12. (436 aa)
LOC101164922Cathepsin K; Belongs to the peptidase C1 family. (331 aa)
LOC101165175Cathepsin S, ortholog2, tandem duplicate 1; Belongs to the peptidase C1 family. (339 aa)
LOC101165916MCL1 apoptosis regulator, BCL2 family member b. (285 aa)
LOC101162015Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a. (303 aa)
pofut2Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (481 aa)
LOC101168255Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (450 aa)
lmnaLamin A; Belongs to the intermediate filament family. (634 aa)
cflarFLICE-like inhibitory protein; Belongs to the peptidase C14A family. (460 aa)
endogEndonuclease. (303 aa)
LOC101165186V-fos FBJ murine osteosarcoma viral oncogene homolog Aa. (378 aa)
LOC101167626TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (569 aa)
akt1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (496 aa)
LOC101165526Cathepsin Bb; Belongs to the peptidase C1 family. (330 aa)
H2MSU3_ORYLAUncharacterized protein. (420 aa)
LOC101167759Si:ch211-153j24.3. (371 aa)
LOC101175325Uncharacterized protein. (1052 aa)
nfkbiaNuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b. (316 aa)
LOC101171965Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
LOC101160956JunE proto-oncogene, AP-1 transcription factor subunit. (425 aa)
H2MXM9_ORYLACaspase 6, apoptosis-related cysteine peptidase a; Belongs to the peptidase C14A family. (209 aa)
LOC101157105Zgc:136872; Belongs to the peptidase C2 family. (699 aa)
LOC101163466Perforin 1.2. (516 aa)
LOC101169541Perforin 1.5. (523 aa)
LOC101158094Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (251 aa)
ctslCathepsin L; Belongs to the peptidase C1 family. (336 aa)
LOC101163728Uncharacterized protein. (409 aa)
AtmUncharacterized protein. (147 aa)
LOC101164997Mitogen-activated protein kinase. (384 aa)
ripk1Receptor (TNFRSF)-interacting serine-threonine kinase 1, like. (675 aa)
LOC101160005Cathepsin S, ortholog 1; Belongs to the peptidase C1 family. (330 aa)
ctshCathepsin H; Belongs to the peptidase C1 family. (324 aa)
dffbDNA fragmentation factor, beta polypeptide (caspase-activated DNase). (342 aa)
LOC101168799Mitogen-activated protein kinase. (488 aa)
LOC101155642Zgc:55262; Belongs to the peptidase C2 family. (705 aa)
LOC101154954Zgc:55558. (189 aa)
Parp4Uncharacterized protein. (351 aa)
badBCL2 associated agonist of cell death b. (164 aa)
map3k5Mitogen-activated protein kinase kinase kinase 5. (1350 aa)
LOC101162579Calpain 2, (m/II) large subunit b; Belongs to the peptidase C2 family. (697 aa)
ddit3CCAAT/enhancer-binding protein-homologous protein. (308 aa)
casp7Caspase 7, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (314 aa)
LOC101168459Baculoviral IAP repeat containing 5b. (147 aa)
nfkb1Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1. (922 aa)
krasGTPase KRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (By similarity). Plays an important role in the regulation of cell proliferation. (189 aa)
LOC101172833Tumor necrosis factor receptor superfamily, member a. (447 aa)
LOC101159035Septin 4a; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (466 aa)
LOC101163042Ribosomal_L7Ae domain-containing protein. (216 aa)
LOC101161875Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (247 aa)
ENSORLP00000032968Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (287 aa)
LOC101155224Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (514 aa)
LOC101162606Growth arrest and DNA-damage-inducible, gamma a. (218 aa)
pik3r3Phosphoinositide-3-kinase, regulatory subunit 3b (gamma). (719 aa)
pik3cbPhosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1078 aa)
ptpn13Protein tyrosine phosphatase non-receptor type 13. (2624 aa)
LOC101168604Lamin L3; Belongs to the intermediate filament family. (704 aa)
LOC101167041Uncharacterized protein. (580 aa)
LOC101162468Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
diabloDiablo, IAP-binding mitochondrial protein a. (267 aa)
atf4-2BZIP domain-containing protein. (436 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (163 aa)
c-fosBZIP domain-containing protein. (376 aa)
Sptan1Uncharacterized protein. (173 aa)
ntrk1Tyrosine-protein kinase receptor. (689 aa)
LOC101165300Uncharacterized protein. (217 aa)
eif2ak3Protein kinase domain-containing protein. (1094 aa)
ctszCathepsin Z; Belongs to the peptidase C1 family. (355 aa)
fasUncharacterized protein. (310 aa)
LOC101160296Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (449 aa)
LOC101162905Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (369 aa)
ENSORLP00000039815EF-hand domain-containing protein. (246 aa)
LOC101166883X-linked inhibitor of apoptosis. (408 aa)
LOC101156378Uncharacterized protein; Belongs to the peptidase C14A family. (287 aa)
LOC101168687Zgc:153993. (293 aa)
LOC101159737Fas ligand (TNF superfamily, member 6); Belongs to the tumor necrosis factor family. (269 aa)
traddTnfrsf1a-associated via death domain. (321 aa)
casp9Caspase 9, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (438 aa)
LOC101159503BH4_2 domain-containing protein. (230 aa)
LOC101168810Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (451 aa)
LOC101163842Calpain 1, (mu/I) large subunit a; Belongs to the peptidase C2 family. (704 aa)
faddUncharacterized protein. (192 aa)
dab2ipDAB2 interacting protein b. (1253 aa)
pik3cdPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1039 aa)
CASP6Caspase 6; Belongs to the peptidase C14A family. (292 aa)
LOC101167538Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (457 aa)
LOC101155619Ribosomal_L7Ae domain-containing protein. (140 aa)
LOC101173230Uncharacterized protein. (340 aa)
LOC101165110Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
Your Current Organism:
Oryzias latipes
NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka
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