68 items (Oryzias latipes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SPHK1	Sphingosine kinase 1. (467 aa)
	LOC101174244	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	ppp3r1	Uncharacterized protein. (170 aa)
	pik3r1	Phosphoinositide-3-kinase, regulatory subunit 1 (alpha). (728 aa)
	LOC105354522	Rac family small GTPase 3b. (197 aa)
	map2k2	Mitogen-activated protein kinase kinase 2a; Belongs to the protein kinase superfamily. (397 aa)
	LOC101174851	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	LOC101162612	Serine/threonine-protein phosphatase. (549 aa)
	LOC101164658	Uncharacterized protein. (242 aa)
	SRC	Tyrosine-protein kinase. (544 aa)
	map2k1	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (394 aa)
	LOC101166150	Heat shock protein, alpha-crystallin-related, b15; Belongs to the small heat shock protein (HSP20) family. (198 aa)
	PRKCB	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (680 aa)
	LOC101159746	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (670 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	LOC101168152	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	LOC101175696	Mitogen-activated protein kinase. (354 aa)
	LOC101154993	Mitogen-activated protein kinase. (368 aa)
	ptgs2	EGF-like domain-containing protein. (607 aa)
	pla2g4a	Phospholipase A2. (745 aa)
	LOC101155144	Uncharacterized protein. (466 aa)
	hras	HRas proto-oncogene, GTPase a. (189 aa)
	raf1	Raf-1 proto-oncogene, serine/threonine kinase a. (677 aa)
	LOC101159747	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (389 aa)
	CDC42	Cell division cycle 42. (191 aa)
	LOC101160322	DAGKc domain-containing protein. (560 aa)
	LOC101159256	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa)
	PRKCA	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (709 aa)
	LOC101155451	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (482 aa)
	plcg2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1247 aa)
	MAPKAPK2	MAPK activated protein kinase 2a; Belongs to the protein kinase superfamily. (389 aa)
	LOC101172250	Serine/threonine-protein phosphatase. (511 aa)
	LOC101171005	Nuclear factor of activated T cells 2a. (893 aa)
	LOC101159668	Mitogen-activated protein kinase. (361 aa)
	akt1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (496 aa)
	H2MSU3_ORYLA	Uncharacterized protein. (420 aa)
	pla2g4c	Uncharacterized protein. (377 aa)
	LOC101163728	Uncharacterized protein. (409 aa)
	LOC101156706	Serine/threonine-protein phosphatase. (514 aa)
	LOC101160731	Mitogen-activated protein kinase. (360 aa)
	LOC101168674	Uncharacterized protein. (179 aa)
	kdr	Kinase insert domain receptor (a type III receptor tyrosine kinase); Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1328 aa)
	LOC101174454	Uncharacterized protein. (191 aa)
	LOC101165879	RHD domain-containing protein. (888 aa)
	LOC101161464	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (666 aa)
	LOC101154954	Zgc:55558. (189 aa)
	bad	BCL2 associated agonist of cell death b. (164 aa)
	vegfa	Vascular endothelial growth factor Ab; Belongs to the PDGF/VEGF growth factor family. (214 aa)
	plcg1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1311 aa)
	kras	GTPase KRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (By similarity). Plays an important role in the regulation of cell proliferation. (189 aa)
	LOC101160262	Sphingosine kinase 2. (886 aa)
	pik3r3	Phosphoinositide-3-kinase, regulatory subunit 3b (gamma). (719 aa)
	LOC101159016	Uncharacterized protein. (192 aa)
	pik3cb	Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1078 aa)
	LOC101164400	Uncharacterized protein. (191 aa)
	LOC101162468	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	LOC101162042	Mitogen-activated protein kinase. (361 aa)
	LOC101164480	Tyrosine-protein kinase. (551 aa)
	vegfb	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (237 aa)
	LOC101164921	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (704 aa)
	LOC101162905	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (369 aa)
	LOC101175028	Uncharacterized protein. (192 aa)
	shc2	SHC (Src homology 2 domain containing) transforming protein 2. (711 aa)
	LOC101163549	Uncharacterized protein. (192 aa)
	casp9	Caspase 9, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (438 aa)
	LOC101171750	Paxillin b. (1108 aa)
	LOC101168142	Serine/threonine-protein phosphatase. (522 aa)
	pik3cd	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1039 aa)

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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structured XML interaction data, according to the 'PSI-MI' data standard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDC42	H2MSU3_ORYLA	ENSORLP00000015084	ENSORLP00000021836	Cell division cycle 42.	Uncharacterized protein.	0.494
CDC42	LOC101154993	ENSORLP00000015084	ENSORLP00000011305	Cell division cycle 42.	Mitogen-activated protein kinase.	0.795
CDC42	LOC101155451	ENSORLP00000015084	ENSORLP00000017781	Cell division cycle 42.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.418
CDC42	LOC101159016	ENSORLP00000015084	ENSORLP00000034283	Cell division cycle 42.	Uncharacterized protein.	0.607
CDC42	LOC101159256	ENSORLP00000015084	ENSORLP00000016665	Cell division cycle 42.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.552
CDC42	LOC101159668	ENSORLP00000015084	ENSORLP00000020405	Cell division cycle 42.	Mitogen-activated protein kinase.	0.795
CDC42	LOC101160731	ENSORLP00000015084	ENSORLP00000027025	Cell division cycle 42.	Mitogen-activated protein kinase.	0.795
CDC42	LOC101162042	ENSORLP00000015084	ENSORLP00000035635	Cell division cycle 42.	Mitogen-activated protein kinase.	0.795
CDC42	LOC101162468	ENSORLP00000015084	ENSORLP00000035304	Cell division cycle 42.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.418
CDC42	LOC101163549	ENSORLP00000015084	ENSORLP00000040285	Cell division cycle 42.	Uncharacterized protein.	0.607
CDC42	LOC101164480	ENSORLP00000015084	ENSORLP00000036233	Cell division cycle 42.	Tyrosine-protein kinase.	0.617
CDC42	LOC101168152	ENSORLP00000015084	ENSORLP00000011212	Cell division cycle 42.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.667
CDC42	LOC101171750	ENSORLP00000015084	ENSORLP00000040665	Cell division cycle 42.	Paxillin b.	0.558
CDC42	LOC101174244	ENSORLP00000015084	ENSORLP00000001785	Cell division cycle 42.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.418
CDC42	LOC101174851	ENSORLP00000015084	ENSORLP00000006529	Cell division cycle 42.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.418
CDC42	LOC101175028	ENSORLP00000015084	ENSORLP00000039764	Cell division cycle 42.	Uncharacterized protein.	0.607
CDC42	LOC101175696	ENSORLP00000015084	ENSORLP00000011217	Cell division cycle 42.	Mitogen-activated protein kinase.	0.795
CDC42	LOC105354522	ENSORLP00000015084	ENSORLP00000003336	Cell division cycle 42.	Rac family small GTPase 3b.	0.608
CDC42	MAPKAPK2	ENSORLP00000015084	ENSORLP00000019719	Cell division cycle 42.	MAPK activated protein kinase 2a; Belongs to the protein kinase superfamily.	0.520
CDC42	PIK3CA	ENSORLP00000015084	ENSORLP00000011211	Cell division cycle 42.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.667