STRINGSTRING
LOC101166777 LOC101166777 map3k2 map3k2 LOC101165996 LOC101165996 LOC105358374 LOC105358374 H2L6E1_ORYLA H2L6E1_ORYLA H2L8B2_ORYLA H2L8B2_ORYLA map2k5 map2k5 LOC101171518 LOC101171518 H2LEF2_ORYLA H2LEF2_ORYLA LOC101169984 LOC101169984 GNAS GNAS LOC101173805 LOC101173805 LOC101167719 LOC101167719 pdgfrb pdgfrb Adrb1 Adrb1 map2k2 map2k2 LOC100049529 LOC100049529 LOC101168718 LOC101168718 LOC101166373 LOC101166373 SRC SRC map2k1 map2k1 LOC101169046 LOC101169046 drd2 drd2 htr2b htr2b pdgfa pdgfa LOC101175254 LOC101175254 PRKCB PRKCB LOC101159746 LOC101159746 sos2 sos2 PLCB4 PLCB4 PLCB1 PLCB1 LOC101171139 LOC101171139 gucy1a2 gucy1a2 gnai3 gnai3 Itpr2 Itpr2 hras hras raf1 raf1 LOC101159747 LOC101159747 LOC101165720 LOC101165720 LOC101157969 LOC101157969 LOC101162414 LOC101162414 PRKCA PRKCA htr2a htr2a LOC101161353 LOC101161353 grm1 grm1 LOC101159207 LOC101159207 LOC101167700 LOC101167700 LOC101160964 LOC101160964 LOC101155351 LOC101155351 LOC101163149 LOC101163149 LOC101171193 LOC101171193 grb2 grb2 LOC101170140 LOC101170140 LOC101157265 LOC101157265 pofut2 pofut2 LOC101168255 LOC101168255 LOC101162245 LOC101162245 csnk1d csnk1d H2MSF0_ORYLA H2MSF0_ORYLA egfr egfr prkg2 prkg2 cdk1 cdk1 fabp2 fabp2 pdgfra pdgfra adcy7 adcy7 pdgfb pdgfb ADCY3 ADCY3 LOC101166500 LOC101166500 prkacb prkacb adcy6 adcy6 LOC101160233 LOC101160233 LOC101166369 LOC101166369 LOC101157651 LOC101157651 LOC101161464 LOC101161464 prkg1 prkg1 LOC101154954 LOC101154954 LOC101169035 LOC101169035 kras kras gnai2 gnai2 adcy8 adcy8 LOC101175365 LOC101175365 LOC101163742 LOC101163742 LOC101155224 LOC101155224 egf egf GJD2 GJD2 pdgfc pdgfc LOC101164480 LOC101164480 plcb2 plcb2 LOC101156428 LOC101156428 LOC101164921 LOC101164921 adcy5 adcy5 LOC101160296 LOC101160296 LOC101162905 LOC101162905 grm5 grm5 LOC101168810 LOC101168810 LOC101165845 LOC101165845 LOC101166121 LOC101166121 pdgfd pdgfd LOC101172459 LOC101172459 LOC101167538 LOC101167538 lpar1 lpar1 LOC101170876 LOC101170876
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC101166777Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (449 aa)
map3k2Mitogen-activated protein kinase kinase kinase 2. (650 aa)
LOC101165996cGMP-dependent protein kinase. (768 aa)
LOC105358374Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2b. (355 aa)
H2L6E1_ORYLAGuanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (364 aa)
H2L8B2_ORYLADopamine receptor D1b; Belongs to the G-protein coupled receptor 1 family. (466 aa)
map2k5Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (445 aa)
LOC101171518Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (449 aa)
H2LEF2_ORYLATubulin domain-containing protein. (136 aa)
LOC101169984Receptor protein-tyrosine kinase. (1191 aa)
GNASUncharacterized protein. (379 aa)
LOC101173805Glutamate receptor, metabotropic 5a. (1179 aa)
LOC101167719Uncharacterized protein. (357 aa)
pdgfrbPlatelet-derived growth factor receptor, beta polypeptide; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1112 aa)
Adrb1Adrenoceptor beta 1. (403 aa)
map2k2Mitogen-activated protein kinase kinase 2a; Belongs to the protein kinase superfamily. (397 aa)
LOC1000495291-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1237 aa)
LOC101168718Uncharacterized protein. (358 aa)
LOC101166373GNAS complex locus. (379 aa)
SRCTyrosine-protein kinase. (544 aa)
map2k1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (394 aa)
LOC101169046G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (372 aa)
drd2Dopamine receptor D2a; Belongs to the G-protein coupled receptor 1 family. (467 aa)
htr2b5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled. (473 aa)
pdgfaPlatelet-derived growth factor alpha polypeptide b; Belongs to the PDGF/VEGF growth factor family. (227 aa)
LOC101175254Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (306 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (680 aa)
LOC101159746Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (670 aa)
sos2Son of sevenless homolog 2 (Drosophila). (1323 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1242 aa)
LOC101171139Platelet-derived growth factor alpha polypeptide a; Belongs to the PDGF/VEGF growth factor family. (199 aa)
gucy1a2Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (806 aa)
gnai3Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numer [...] (354 aa)
Itpr2Inositol 1,4,5-trisphosphate receptor, type 2. (1587 aa)
hrasHRas proto-oncogene, GTPase a. (189 aa)
raf1Raf-1 proto-oncogene, serine/threonine kinase a. (677 aa)
LOC101159747Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (389 aa)
LOC101165720Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1110 aa)
LOC101157969Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (444 aa)
LOC101162414Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1011 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (709 aa)
htr2a5-hydroxytryptamine (serotonin) receptor 2A, genome duplicate a. (487 aa)
LOC101161353Guanine nucleotide binding protein (G protein), alpha 11b (Gq class). (359 aa)
grm1Glutamate receptor, metabotropic 1a. (1158 aa)
LOC101159207Adenylate cyclase 2b (brain); Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (851 aa)
LOC101167700Inositol 1,4,5-trisphosphate receptor, type 1a. (2664 aa)
LOC101160964Uncharacterized protein; Belongs to the protein kinase superfamily. (359 aa)
LOC101155351Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (450 aa)
LOC101163149Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1453 aa)
LOC101171193Dopamine receptor D2 like; Belongs to the G-protein coupled receptor 1 family. (487 aa)
grb2Growth factor receptor-bound protein 2b. (218 aa)
LOC101170140Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (392 aa)
LOC101157265Uncharacterized protein. (354 aa)
pofut2Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (481 aa)
LOC101168255Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (450 aa)
LOC101162245Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (453 aa)
csnk1dCasein kinase 1, delta b; Belongs to the protein kinase superfamily. (405 aa)
H2MSF0_ORYLASi:dkey-121j17.5; Belongs to the protein kinase superfamily. (339 aa)
egfrReceptor protein-tyrosine kinase. (1185 aa)
prkg2cGMP-dependent protein kinase. (769 aa)
cdk1Cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis. Component of the kinase complex that phosphorylates the repetitive C- terminus of RNA polymerase II. Catalytic component of MPF (By similarity); Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. (303 aa)
fabp2Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (570 aa)
pdgfraPlatelet-derived growth factor receptor, alpha polypeptide; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1460 aa)
adcy7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1099 aa)
pdgfbPlatelet-derived growth factor beta polypeptide a; Belongs to the PDGF/VEGF growth factor family. (553 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1119 aa)
LOC101166500Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1167 aa)
prkacbUncharacterized protein; Belongs to the protein kinase superfamily. (380 aa)
adcy6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1209 aa)
LOC101160233Tight junction protein 1b; Belongs to the MAGUK family. (1856 aa)
LOC101166369Tight junction protein 1a; Belongs to the MAGUK family. (1748 aa)
LOC101157651Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (1127 aa)
LOC101161464Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (666 aa)
prkg1cGMP-dependent protein kinase. (684 aa)
LOC101154954Zgc:55558. (189 aa)
LOC101169035Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1179 aa)
krasGTPase KRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (By similarity). Plays an important role in the regulation of cell proliferation. (189 aa)
gnai2Guanine nucleotide-binding protein G(i) subunit alpha-2; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta- adrenergic stimuli. May play a role in cell division (By similarity). (355 aa)
adcy8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1231 aa)
LOC1011753651-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1161 aa)
LOC101163742Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily. (377 aa)
LOC101155224Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (514 aa)
egfEpidermal growth factor. (966 aa)
GJD2Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (304 aa)
pdgfcPlatelet derived growth factor c; Belongs to the PDGF/VEGF growth factor family. (342 aa)
LOC101164480Tyrosine-protein kinase. (551 aa)
plcb21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1248 aa)
LOC101156428Uncharacterized protein. (1034 aa)
LOC101164921Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (704 aa)
adcy5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1196 aa)
LOC101160296Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (449 aa)
LOC101162905Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (369 aa)
grm5Glutamate receptor, metabotropic 5b. (1239 aa)
LOC101168810Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (451 aa)
LOC1011658455-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled-like 1. (578 aa)
LOC101166121Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (473 aa)
pdgfdPlatelet derived growth factor d. (404 aa)
LOC101172459Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1203 aa)
LOC101167538Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (457 aa)
lpar1Lysophosphatidic acid receptor 1; Belongs to the G-protein coupled receptor 1 family. (352 aa)
LOC101170876Uncharacterized protein; Belongs to the protein kinase superfamily. (354 aa)
Your Current Organism:
Oryzias latipes
NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka
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